Objective To compare the effect of low-fluence photodynamic therapy （PDT） in patients with central serous chorioretinopathy （CSC） by evaluation with MP-1 microperimetry and BCVA and to monitor central retinal functional changes. Methods This was a prospective longitudinal self-controlled case series study. Thirty-four patients （34 eyes） with CSC who received low-fluence PDT were enrolled from March 4 2011 to July 28 2011 in our hospital. BCVA and OCT were evaluated at baseline and at 3， 6， and 12 months after PDT. Retinal sensitivity in the central 12 degrees and fixation stability were evaluated by MP-1 microperimetry at baseline and at 3 months after PDT. The changes in BCVA and mean central retinal sensitivity were analyzed by a chi-square test. Linear regression was used to compare the retinal sensitivity measured by microperimetry and BCVA. Results The mean BCVA at 12 months after PDT （85.5±6.8）letters was significantly higher than that at baseline （78.1±6.9）letters （t=78.05， P<0.01）. The mean retinal sensitivity measured by microperimetry at 3 months after PDT was （17.2±2.1）dB， which was significantly higher than that at baseline （13.8±3.7）dB （t=19.28， P<0.01）. The retinal thickness measured by OCT at 12 months after PDT （239.2±21.0）μm was significantly thinner than that at baseline （432.7±142.5）μm （t=18.34， P<0.01）. Mann-Whitney nonparametric analysis showed that the changes in BCVA and microperimetry from baseline to 3 months after treatment were not significantly different （Z=-1.1191， P=0.234）. Linear regression analysis showed that BCVA was correlated with microperimetry both at baseline （r=0.5， P<0.05） and after treatment （r=0.6， P<0.05）， while OCT showed no relationship to microperimetry（r=0.01， 0.002； P=0.79， 0.68）. Conclusion Low-fluence PDT in patients with CSC can improve BCVA， promote the absorption of the subretinal fluid in the macular region， and improve retinal sensitivity in the macular region. The microperimeter is a useful tool combined with BCVA to monitor the functional changes of eyes with CSC.
焦璇,赵萌,周海英,熊颖,纪海霞,张风. 中心性浆液性脉络膜视网膜病变光动力治疗后微视野的改变[J]. 中华眼视光学与视觉科学杂志, 2013, 15(1): 5-9.
JIAO Xuan,ZHAO Meng,ZHOU Hai-ying,XIONG Ying,JI Hai-xia,ZHANG Feng. Changes in the microperimeter of patients with central serous chorioretinopathy treated by low-fluence photodynamic therapy. Chinese Journal of Optometry Ophthalmology and Visual Science, 2013, 15(1): 5-9. DOI: 10.3760/cma.j.issn.1674-845X.2013.01.002
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