Objective  To retrospectively evaluate choroidal thickness after treatment by photodynamic therapy （PDT） or laser photocoagulation （LP） in eyes with acute central serous chorioretinopathy （CSC） using enhanced depth imaging spectral-domain optical coherence tomography （EDI-OCT）. Methods  In this retrospective study， 39 eyes of 39 patients with idiopathic acute CSC were recruited， after the following comprehensive ocular examinations were performed： best-corrected visual acuity （BCVA）， slit-lamp biomicroscopy， indirect ophthalmoscopy， fundus photography， fluorescein angiography （FFA）， and indocyanine green angiography （ICGA）. Patients were divided into 2 types based on FFA characteristics： points of leakage in the foveal avascular zone （FAZ） and points of leakage out from the FAZ. The first type， which is not amenable to LP， was treated with a half-dose of verteporfin PDT guided by ICGA， whereas the other type was treated with LP. Subfoveal choroidal thickness and choroidal thickness at 1500 μm temporal， nasal， superior， and inferior to the fovea were measured. The choroidal thickness was measured with enhanced depth imaging OCT before treatment at baseline， and 1 and 3 months after treatment. The results of the choroidal thickness measurements were analyzed using a repeated measurement ANOVA. Results  In the PDT group， choroidal thickness at all evaluating points had decreased significantly within 3 months compared to baseline. Whereas in the LP group， choroidal thickness had decreased significantly within 3 months only at 1500 μm superior and temporal to the fovea compared to baseline. Conclusion  PDT reduces choroidal vascular hyperpermeability by remodeling the choroidal vascular system resulting in the reduction of choroidal thickness in the macular region and may work by a different mechanism than LP， which targets RPE.