Objective  To observe the effect of stellate ganglion block on central serous chorioretinopathy （CSC） associated with cerebral vascular spasm. Methods  This was a retrospective case control study. Seventy patients with ipsilateral middle cerebral artery eye spasm who had been diagnosed with central serous chorioretinopathy were screened by transcranial doppler （TCD） examination. Fundus fluorescein angiography （FFA）， optical coherence tomography （OCT）， Amsler grid and anterior and posterior segment examination were performed. The patients were then divided into an observation group and a control group. The control group was treated with traditional oral drugs to improve microcirculation （vitamin B， vitamin E， dibazol and compound danshen drops） and the observation group was treated with an oral stellate ganglion block to improve microcirculation. Treatment was given once on alternate days and on 4 consequetive days during one span of the treatment period. Vision， fundus and FFA changes in the two groups of patients were compared at 1， 2， 4， 8 and 12 weeks. A chi square test was used to compare the total rate of effectiveness for the two groups. Results  The total rates of effectiveness for the treatment and control groups were 94.4% and 70.6%. There was a statistically significant difference between the two groups （χ2=7.00， P<0.01）. The course of the treatment was shorter for the treatment group than for the control group. Conclusion  Stellate ganglion block may be effective in the treatment of central serous chorioretinopathy associated with cerebral vascular spasm.