Objective To study the occurrence and prevention and treatment of corneal epithelial ingrowth after femtosecond laser assisted laser in situ keratomileusis （LASIK）. Methods A retrospective analysis was performed on 1 122 patients （2 236 eyes） who underwent femtosecond laser surgery at our hospital from October 2013 to July 2014. BCVA＞1.0 was found in a routine preoperative check. Intralase femtosecond laser at 60 kHz was used to complete the surgery and a digital camera was used to record the entire procedure. Patients were followed up for 3 months postoperatively to monitor corneal epithelial ingrowth. Results Corneal epithelial ingrowth occurred in 28 eyes （1.25%） by one month postoperatively. Of these， 18 eyes （0.81%） had level Ⅰ epithelial ingrowth. On the first day postoperatively 8 eyes （0.36%） had level Ⅱ epithelial ingrowth but did not appear to have local flap melting or irregular astigmatism. On postoperative day 1， two eyes （0.09%） had level Ⅱ diffuse lamellar keratitis. This condition disappeared after one week of applying 1% prednisolone acetate eyedrops 4 times a day， but at 1 month after surgery， they developed level Ⅲ epithelial ingrowth with corneal flap edge fusion. Conclusion The incidence of epithelial implantation was low after femtosecond laser surgery. A combination of preoperative screening， standardized surgery， close postoperative observation and timely treatment are effective means for the prevention and treatment of corneal epithelial endogenous.
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