我国江浙沪正常人上睑板腺特征的年龄相关性研究

doi:DOI:10.3760/cma.j.issn.1674-845X.2016.06.008

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摘要

目的观察分析不同年龄组正常国人上睑板腺（UMG）的临床特征。方法横断面研究。对792例（1 584眼）江浙沪地区汉族健康志愿者依年龄分10组（自1岁开始，10岁为一组）。收集UMG图像评级（Grade）、UMG形态学指标[数目（n）、密度（d）、平均宽度（WA）、平均长度（LA）、所占面积比（RA）]、睑缘形态异常评分（LAS）、睑板腺评分（M）、睑板腺分泌评分（MS）、角膜荧光素钠染色积分（FI）、泪膜破裂时间（BUT）和泪液分泌试验（SⅠT）等指标。各指标与年龄制作统计图行描述性分析，并运用相关性分析观察各参数与年龄的相关性；不同性别间指标行非参数检验或t检验分析。结果 UMG各形态学及临床学指标在性别间除51～60岁组的M和71～80岁组的n外（t＝-3.162、-2.291，P＜0.05），余差异无统计学意义（P>0.05）。n、d、LA、RA、M和BUT均与年龄呈负相关（r=-0.625、-0.493、-0.593、-0.862、-0.322、-0.521，P均<0.05）；Grade、WA、LAS、MS、FI均与年龄呈正相关（r=0.296、0.255、0.527、0.303、0.228，P均<0.05）；SⅠT与年龄无相关性（r=-0.125，P＞0.05）。结论正常江浙沪汉族国人存在与年龄相关的上睑板腺形态学及临床学参数改变的趋势。

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	廖桂仪
	孙小婷
	周祁
	陈冉冉
	刘振兴
	毕燕龙

关键词 ：睑板腺, 睑板腺功能障碍, 形态学, 睑板腺成像

Abstract：

Objective To clarify the morphological characteristics of the upper eyelid′s meibomian gland (UMG) in different age groups of a healthy Chinese Han population. Methods This was a cross-sectional observation case series. Seven hundred and ninety-two healthy volunteers (1 584 eyes) were grouped into ten age groups based on ten-year increments, starting at age one. Data collected included the meibomian 5-scale grading (Grade), No.(n), density(d), average width (WA), average length (LA) and area ratio (RA) of the upper meibomian glands. The data on the lid abnormality score (LAS), meibo-score (M), meibum secretion (MS), fluorescence integral (FI), tear film break-up time (BUT) and Schirmer test Ⅰ (SⅠT) were also collected. Data were analyzed using correlation, nonparameter and t test. Results There were no statistical interocular or inter-gender differences in the overall healthy volunteers (P<0.05). n, d, LA, RA, M and BUT were negatively correlated with age (separately, r=-0.625, -0.493, -0.593, -0.862, -0.322, -0.521, all P<0.05), while Grade, WA, LAS, MS and FI were found to have a positive correlation with age (separately, r=0.296, 0.255, 0.527, 0.303, 0.228, all P<0.05). There was no significant correlation between SⅠT and age (r=-0.125, P>0.05). Conclusion Morphological and clinical data of UMG show a significant age-related degenerative change in Chinese Han population.

Key words： Meibomian glands Meibomian gland dysfunction Morphology Meibography

收稿日期: 2016-01-08

基金资助:

上海市普陀区高层次人才科研创新项目（2014-A-25）

通讯作者: 毕燕龙，Email：biyanlong@tongji.edu.cn

引用本文:

廖桂仪,孙小婷,周祁,陈冉冉,刘振兴,毕燕龙. 我国江浙沪正常人上睑板腺特征的年龄相关性研究[J]. 中华眼视光学与视觉科学杂志, 2016, 18(6): 353-357. Liao Guiyi,Sun Xiaoting,Zhou Qi,Chen Ranran,Liu Zhenxing,Bi Yanlong. Morphological and clinical characteristics of the upper meibomian gland in different age groups of healthy Chinese. Chinese Journal of Optometry Ophthalmology and Visual science, 2016, 18(6): 353-357.

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