Ocular trauma with coagulation factor deficiencies is rarely seen in ophthalmology. Complications such as visual loss, tissue ischemia and necrosis can occur if it is not treated in a timely and regular fashion. We report on five cases of ocular trauma with coagulation factor deficiencies that were encountered from August 2009 to January 2015 and an analysis of their clinical features, laboratory examinations and therapies. Ophthalmic clinical doctors encountering patients with ocular trauma who keep bleeding should realize the possibility of coagulation factor deficiencies, treat it in a timely and regular fashion, and prevent the occurrence and aggravation of complications.