Recent approaches utilizing tissue manipulations in developing embryonic lenses have revealed that, a host of growth factors were expressed and even played major roles in different stages of lens development. The balanced status, which is essential for the lens normal development, was maintained by complex interactions between different growth factors, or may cause pathological changes if the balanced status breaks updown. This paper reviews the latest research findings about the growth factors needed for lens development. The growth factor regulatory network, which plays an indispensable role in maintaining lens development, is summarized in this review, based on the targeted areas. This will provide a aparadigm for the mechanisms study of cataract and lens regeneration in in vivo culture as well as the precision therapy using targeted medicine.
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