325027 温州医科大学附属眼视光医院 眼视光学院 生物工程学院（彭晨蕾、William Robert Kwapong、周煜恒、沈梅晓、瞿佳）；325027 温州医科大学附属第二医院 育英儿童医院神经内科（何志勇）
Using High-Resolution SD-OCT to Detect Changes in Retinal Thickness in Neuromyelitis Optica Spectrum Disorders
Chenlei Peng, William Robert Kwapong, Yuheng Zhou, Zhiyong He,Meixiao Shen, Jia Qu
1Eye Hospital, School of Ophthalmology & Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, China
2The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China
Objective: We used ultra-high resolution spectral domain optical coherence tomography (UHR-OCT) to analyze the subclinical changes in retinal neurons, axon injury, and retinal thickness in neuromyelitis opticaspectrum disorders (NMOSD) patients. Methods: This case-control study included 21 cases of NMOSD patients and 20 matched healthy volunteers (control group). The NMOSD patients were divided into a subgroup without optic neuritis (NO-ON) (13 eyes) and a subgroup with optic neuritis (ON) group (13 eyes). The thickness of the total retina of each patient and control subject was evaluated by using UHR-OCT. Data of each layer were analyzed using one-way ANOVA. Results: Except at the central region, the total retinal thickness of the ON group in whole mapping images was significantly thinner than the control group and NO-ON group. There were significant differences in total thickness between the NO-ON group and the control group in some regions (nasal interior [NI], P=0.011; temporal interior[TI], P=0.003; superior exterior [SE], P=0.019; inferior exterior [IE], P=0.002). The thicknesses of the retinal nerve fiber layer (RNFL) and the combined ganglion cell layer and inner plexiform layer (GCL+IPL) in the ON group was significantly thinner in each quadrant compared with the control group (P < 0.001). The RNFL thickness of the NO-ON group was thinner in the nasal and temporal areas compared with the control group (NI, P=0.049; TI and temporal exterior [TE], P < 0.001). The GCL+IPL thickness in the NO-ON group was thinner than control group (SE, P < 0.001; IE, P=0.002). The thickness of inner nuclear layer (INL) in the ON group was thicker than in the control group (superior interior [SI], P=0.001; inferior interior [II],
P=0.003; TE, P=0.043); however the thickness of the INL in the NO-ON group was thinner than in the control group (SE, P=0.015; IE, P=0.012). The thickness of Henle fiber layer and outer nuclear layer (HFL+ONL) in the NO-ON group was thinner than for the control group (SI, P=0.009; SE, P=0.018; II, P=0.001; IE, P=0.001 ), but there were no significant differences between the ON group and the control group. Conclusions: There were significant changes in the different retinal layers of NMOSD patients compared to healthy controls. The thicknesses of RNFL and GCIPL in the NO-ON subgroup were decreased,suggesting that NMOSD patients with no optic neuritis potentially have structural damage in the retinal nerve.
彭晨蕾,William Robert Kwapong,周煜恒,何志勇,沈梅晓,瞿佳. 运用高分辨SD-OCT探测视神经脊髓炎谱系疾病视网膜厚度变化[J]. 中华眼视光学与视觉科学杂志, 2018, 20(7): 385-392.
Chenlei Peng, William Robert Kwapong, Yuheng Zhou, Zhiyong He,Meixiao Shen, Jia Qu. Using High-Resolution SD-OCT to Detect Changes in Retinal Thickness in Neuromyelitis Optica Spectrum Disorders. Chinese Journal of Optometry Ophthalmology and Visual science, 2018, 20(7): 385-392. DOI: 10.3760/cma.j.issn.1674-845X.2018.07.001
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