Objective: To demonstrate that the RCS (rdy-/-, p-/-) rat model for retinitis pigmentosa has a blood stasis and deficiency pathogenesis. Methods: This was an experimental study. Ten RCS (rdy+/+, p+/+) rats were in the control group (5 males and 5 females); 10 RCS (rdy-/-, p-/-) rats were in the model group (5 males and 5 females). The general morphological and behavioral characteristics of the two groups of rats were observed to evaluate the biological differences between them. ELISA was used to determine the indicators of blood stasis and deficiency. The indicators of deficiency included cAMP, cGMP and cAMP/cGMP levels in retinal homogenate tissue, and plasma PG and E2 levels. The indicators of blood stasis were the P-selectin level in plasma, and hemorheology indexes. Tissue sections with HE staining were used to observe the retinal structures of the rats in the two groups. Independent sample t tests were performed on both sets of data. results: The rats in the model group manifested significant weight loss,fatigue, unresponsiveness, slow movements, volumized and dull back hair, vulnerability to fright, low food intake, and slightly loose stools. The plasma E2 content in female rats was significantly lower than that in the control group, and the difference was statistically significant (t=2.67, P=0.03). The plasma PG content in the male rats of the model group was lower than that of the control male rats, and the difference was statistically significant (t=4.12, P=0.003). The levels of cAMP, cGMP, and cAMP/cGMP in retinal tissue homogenates of the control group were higher than levels in the model group, and the difference was statistically significant (t=18.87, 12.63, 11.76, P < 0.001). When the blood flow shear forces were 5/s, 100/s,and 200/s, the blood viscosity of the model group was higher than that of the control group, and the difference was statistically significant (t=5.58, 4.40, 6.80, P < 0.001). The plasma viscosity value, whole blood high incision relative index, whole blood low incisionrelative index, and fibrinogen in the model group were higher than those in the control group, and the difference was statistically significant (t=5.20,8.25, 9.08, 6.15, P < 0.001). The content of P-selectin in the plasma of the model group was significantly higher than that of the control group (t=4.30, P=0.003). The retinal thickness of rats in the model group was significantly thinner than that of the control group, and the structure of each layer of the rat's retina in the model group was disordered and atrophic. The lesions were mainly located in the outer layer of the retina, and the cones and rods were atrophic. conclusions: The RCS (rdy-/-, p-/-) rat model of retinities pigmentosa has pathophysiological characteristics such as body weight loss, deficiency of kidney essence,and blood stasis deficiency.