Retinal Vessel Density in Adolescent Myopia Based on OCTA: An Observational Study
Jun Zeng1, 2, Longqian Liu1
1 Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, China 2 Department of Ophthalmology, The Third People's Hospital of Zigong City, Zigong 643020, China
Abstract:Objective: To investigate the correlation between myopia and superficial retinal vascular density (SRVD) and retinal thickness in adolescent myopia using optical coherence tomography angiography (OCTA). Methods: This study was a prospective cross-sectional study. A total of 105 myopia patients (193 eyes) aged 7-14 years who visited the Department of Ophthalmology, West China Hospital, Sichuan University, from May 2018 to November 2018 were included. All patients were examined by optical coherence tomography (OCT) and OCTA. Patients were divided into three groups based on the degree of myopia:mild, moderate and severe. One-way analysis of variance was performed on the macular foveal retinal thickness and SRVD at various sites. Pearson correlation was performed between the retinal thickness and superficial retinal vessel density by Pearson correlation analysis. Spearman correlation was performed between the spherical equivalent (SE) and the SRVD and between the macular foveal retinal thickness and the SRVD at various sites. Results: The differences in the parafovea, outer ring and the entire 6 mm diameter of the SRVD in the mild, moderate and high myopia groups were statistically significant (F=11.651, 14.499, 14.232, P<0.001). There was a weak positive correlation between age and macular foveal retinal thickness (r=0.187, P=0.011), but there was no correlation between age and SRVD at any site. The SE was correlated with the parafoveal SRVD (r=-0.301, P<0.001), the curve was correlated with the SRVD outer ring and the entire SRVD area (r=-0.319, P<0.001; r=-0.307, P<0.001). However, there was no significant correlation between the SE and the foveal SRVD and macular foveal retinal thickness. The macular foveal retinal thickness was correlated with the foveal SRVD (r=0.691, P<0.001), but no correlation with parafoveal, outer ring and entire SRVD. Conclusions: The degree of myopia in adolescents is negatively correlated with the parafovea, outer ring and the entire SRVD. The macular foveal retinal thickness is positively correlated with age and the foveal SRVD.
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Jun Zeng1, 2, Longqian Liu1. Retinal Vessel Density in Adolescent Myopia Based on OCTA: An Observational Study. Chinese Journal of Optometry Ophthalmology and Visual science, 2020, 22(5): 354-359. DOI: 10.3760/cma.j.cn115909-20200121-00018
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