傅里叶域OCT对不同屈光状态非青光眼青年人群神经节细胞复合体的观察

doi:10.3760/cma.j.cn115909-20190801-00211

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摘要目的：应用傅里叶域光学相干断层扫描（OCT）观察不同屈光状态非青光眼青年人群神经节细胞复合体（GCC）形态特征，探讨眼轴长度（AL）与GCC的变化规律。方法：病例对照研究。基于AL纳入非高度近视94眼和高度近视62眼，使用OCT测量其黄斑区GCC厚度、上/下半区GCC（GCC-S/GCC-I）厚度、局部丢失体积（FLV）和整体丢失体积（GLV）并计算FLV与GLV比值（FGR）。使用线性回归分析各指标与AL的相关性；采用受试者工作特征曲线下面积（AUC）评价2组间各指标差异及界值。结果：线性回归结果示受试者GCC厚度（β=-0.698，P<0.001）、GCC-S厚度（β=-0.693，P<0.001）、 GCC-I厚度（β=-0.672，P<0.001）随AL延长而下降；FLV不随AL变化而变化（β=0.115，P=0.155）； GLV随AL延长而增高（β=0.346，P<0.001），FGR随AL延长而降低（β=-0.473，P<0.001）。独立样本t检验结果示高度近视组和非高度近视组间GCC厚度（t=7.398，P<0.001）、GCC-S厚度（t=7.313， P<0.001）、GCC-I厚度（t=7.022，P<0.001）、GLV（t=-3.482，P=0.001）及FGR（t=5.361，P<0.001）差异有统计学意义，FLV差异无统计学意义（t=1.057，P=0.292）。AUCGCC为0.809（P<0.001），最佳界值99 μm；AUCGLV为0.689（P<0.001），最佳界值3.42；AUCFGR为0.711（P<0.001），最佳界值0.44； AUCFLV为0.546（P=0.330）。结论：OCT可观察不同屈光状态非青光眼青年人群GCC，平均GCC厚度、 GCC-S厚度、GCC-I厚度、GLV和FGR随AL变化而发生改变。

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关键词 ：光学相干断层扫描, 神经节细胞复合体/病理学, 高度近视, 诊断

Abstract：Objective: To observe the ganglion cell complex (GCC) in non-glaucomatous youth with different refractions using Fourier-domain optical coherence tomography (FD-OCT), and to explore the association between axial length (AL) and GCC parameters. Methods: This was a cross-sectional, observational study. Ninety-four youth (94 eyes) were enrolled in a non-high myopia group and 62 youth (62 eyes) were enrolled in a high myopia group based on AL. The mean macular GCC thickness, superior-half GCC (GCC-S) thickness, inferior-half GCC (GCC-I) thickness, focal loss volume (FLV), global loss volume (GLV) and their ratio (FLV/GLV ratio, FGR) were measured. Linear regression was performed to analyze the correlation between AL and these parameters. The cut-off levels of the GCC parameters between the two groups were analyzed with the area under the curve (AUC) of the receiver operating functions. Results: Linear regression showed that the mean macular GCC thickness (β=-0.698, P<0.001), GCC-S thickness (β=-0.693, P<0.001) and GCC-I thickness (β=-0.672, P<0.001) are reduced as AL increases; FLV (β=0.115, P=0.155) was not significantly correlated with AL; GLV (β=0.346, P<0.001) was positively correlated while FGR (β=-0.473, P<0.001) was negatively correlated with AL. A t-test revealed that there are significant differences in the mean macular GCC thickness (t=7.398, P<0.001), GCC-S thickness (t=7.313, P<0.001), GCC-I thickness (t=7.022, P<0.001), GLV (t=-3.482, P<0.001) and FGR (t=5.361, P<0.001) between the high myopia and non-high myopia groups except for FLV (t=1.057, P=0.292). AUCGCC was 0.809 (P<0.001) and the best differential point was 99 μm; AUCGLV was 0.689 (P<0.001) and the best differential point was 3.42; AUCFGR was 0.711 (P<0.001) and the best differential point was 0.44; while AUCFLV was 0.546 (P=0.330). Conclusions: GCC parameters in non-glaucomatous youth can be evaluated by using FD-OCT, and some parameters change as the AL elongates.

Key words： optical coherence tomography ganglion cell complex/pathology high myopia diagnosis

收稿日期: 2019-08-01

基金资助:上海市医学重点专项建设项目（ZK2019B27）；上海市卫生和健康委员会项目（201740001、2019SY012）；上海市静安区卫生和健康委员会项目（2018MS12、2019QN07）；上海市静安区市北医院院级科研课题（2019SBQN01）

通讯作者: 陈吉利（ORCID：0000-0002-4080-0534），Email：corneachen@163.com

引用本文:

刘瑞1 王莎莎1 许斐平1 何杰1 曹婷怡1 陈吉利1. 傅里叶域OCT对不同屈光状态非青光眼青年人群神经节细胞复合体的观察[J]. 中华眼视光学与视觉科学杂志, 2020, 22(6): 421-426. Rui Liu, Shasha Wang, Feiping Xu, Jie He, Tingyi Cao, Jili Chen. Study of the Ganglion Cell Layer in Non-Glaucomatous Youth with Different Refractions Using Fourier-Domain Optical Coherence Tomography. Chinese Journal of Optometry Ophthalmology and Visual science, 2020, 22(6): 421-426. DOI: 10.3760/cma.j.cn115909-20190801-00211

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https://www.cjoovs.com/CN/10.3760/cma.j.cn115909-20190801-00211 或 https://www.cjoovs.com/CN/Y2020/V22/I6/421

[1]	Ohno-Matsui K, Lai TY, Lai CC, et al. Updates of pathologic myopia. Prog Retin Eye Res, 2016, 52: 156-187. DOI: 10.1016/ j.preteyeres.2015.12.001.
[2]	Holden BA, Fricke TR, Wilson DA, et al. Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050. Ophthalmology, 2016, 123(5): 1036-1042. DOI: 10.1016/ j.ophtha.2016.01.006.
[3]	Mohammad Noureldine A, Hashem Fouad P, Magdy Ahmed H, et al. Early diagnostic parameters of glaucoma in high myopes.J Fr Ophtalmol, 2019, 42(5): 457-463. DOI: 10.1016/j.jfo.2018. 11.011.
[4]	Xu L, Wang Y, Wang S, et al. High myopia and glaucoma susceptibility the Beijing Eye Study. Ophthalmology, 2007, 114(2): 216-220. DOI: 10.1016/j.ophtha.2006.06.050.
[5]	Zhao Z, Jiang C. Effect of myopia on ganglion cell complex and peripapillary retinal nerve fibre layer measurements: A Fourierdomain optical coherence tomography study of young Chinese persons. Clin Exp Ophthalmol, 2013, 41(6): 561-566. DOI: 10.1111/ceo.12045.
[6]	Zhang X, Loewen N, Tan O, et al. Predicting development of glaucomatous visual field conversion using baseline fourierdomain optical coherence tomography. Am J Ophthalmol, 2016, 163: 29-37. DOI: 10.1016/j.ajo.2015.11.029.
[7]	Rimayanti U, Latief MA, Arintawati P, et al. Width of abnormal ganglion cell complex area determined using optical coherence tomography to predict glaucoma. Jpn J Ophthalmol, 2014, 58(1): 47-55. DOI: 10.1007/s10384-013-0281-5.
[8]	Zhang Y, Wen W, Sun X. Comparison of several parameters in two optical coherence tomography systems for detecting glaucomatous defects in high myopia. Invest Ophthalmol Vis Sci, 2016, 57(11): 4910-4915. DOI: 10.1167/iovs.16-19104.
[9]	Kita Y, Kita R, Takeyama A, et al. Effect of high myopia on glaucoma diagnostic parameters measured with optical coherence tomography. Clin Experiment Ophthalmol, 2014, 42(8): 722-728. DOI: 10.1111/ceo.12318.
[10]	Sezgin Akcay BI, Gunay BO, Kardes E, et al. Evaluation of the ganglion cell complex and retinal nerve fiber layer in low, moderate, and high myopia: A study by RTVue spectral domain optical coherence tomography. Semin Ophthalmol, 2017, 32(6): 682-688. DOI: 10.3109/08820538.2016.1170157.
[11]	Kim HG, Heo H, Park SW. Comparison of scanning laser polarimetry and optical coherence tomography in preperimetric glaucoma. Optom Vis Sci, 2011, 88(1): 124-129. DOI: 10.1097/ OPX.0b013e3181fdef9c.
[12]	Nakanishi H, Akagi T, Hangai M, et al. Sensitivity and specificity for detecting early glaucoma in eyes with high myopia from normative database of macular ganglion cell complex thickness obtained from normal non-myopic or highly myopic Asian eyes. Graefes Arch Clin Exp Ophthalmol, 2015, 253(7): 1143-1152. DOI: 10.1007/s00417-015-3026-y.
[13]	Ueda K, Kanamori A, Akashi A, et al. Effects of axial length and age on circumpapillary retinal nerve fiber layer and inner macular parameters measured by 3 types of SD-OCT instruments. J Glaucoma, 2016, 25(4): 383-389. DOI: 10.1097/ IJG.0000000000000216.
[14]	Yamashita T, Sakamoto T, Terasaki H, et al. Quantification of retinal nerve fiber and retinal artery trajectories using secondorder polynomial equation and its association with axial length. Invest Ophthalmol Vis Sci, 2014, 55(8): 5176-5182. DOI: 10.1167/iovs.14-14105.
[15]	冯虹, 卢艳, 杨慧青, 等. 视野前青光眼视盘及黄斑神经节细胞复合体相关参数测量分析. 中华眼底病杂志, 2014, 30(6): 583-587. DOI: 10.3760/cma.j.issn.1005-1015.2014.06.012.
[16]	李从心, 张阳阳, 李韵秋, 等. 视网膜黄斑区神经节细胞复合体厚度与眼轴长度的相关性研究. 临床眼科杂志, 2015, (2): 97-101. DOI: 10.3969/j.issn.1006-8422.2015.02.001.
[17]	Mwanza JC, Budenz DL, Godfrey DG, et al. Diagnostic performance of optical coherence tomography ganglion cell-inner plexiform layer thickness measurements in early glaucoma. Ophthalmology, 2014, 121(4): 849-854. DOI: 10.1016/j.ophtha.2013.10.044.
[18]	Arintawati P, Sone T, Akita T, et al. The applicability of ganglion cell complex parameters determined from SD-OCT images to detect glaucomatous eyes. J Glaucoma, 2013, 22(9): 713-718. DOI: 10.1097/IJG.0b013e318259b2e1.
[19]	Shoji T, Sato H, Ishida M, et al. Assessment of glaucomatous changes in subjects with high myopia using spectral domain optical coherence tomography. Invest Ophthalmol Vis Sci, 2011, 52(2): 1098-1102. DOI: 10.1167/iovs.10-5922.
[20]	王伟伟, 王怀洲, 刘建荣, 等. 频域OCT测量高度近视黄斑区视网膜神经节细胞复合体厚度及视盘周围视网膜神经纤维层厚度. 中华眼视光学与视觉科学杂志, 2017, 19(12): 720- 726. DOI: 10.3760/cma.j.issn.1674-845X.2017.12.003.