多巴胺在形觉剥夺性近视中作用的研究进展

doi:10.3760/cma.j.cn115909-20200902-00351

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摘要近视作为一种全球发病率最高的屈光不正，其趋势日益增加，已成为眼科研究领域的热点。形觉剥夺性近视是实验性近视中较为成熟的造模方法。众多研究报道多巴胺作为一种调控视网膜及眼球生长微环境的神经递质，通过与多巴胺受体、途径间的相互作用，在形觉剥夺性近视的形成和抑制过程中具有重要意义。现就多巴胺对形觉剥夺性近视的影响及其生化机制进行探讨，以期为近视的实验研究提供参考。

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关键词 ： , 多巴胺, 多巴胺受体, 形觉剥夺性近视

Abstract： Myopia is a refractive error with the highest incidence in the world, and its trend is increasing, which has become a hot spot in the field of ophthalmology research. Form deprivation myopia is a mature method in experimental myopia. Many studies have reported that dopamine, as a neurotransmitter regulating the growth microenvironment of retina and eyeball, plays an important role in the formation and inhibition of form deprivation myopia through the interaction with dopamine receptors and pathways. In this paper, the effect of dopamine on form deprivation myopia and its biochemical mechanism were discussed, in order to provide a reference for the experimental study of myopia.

Key words： dopamine dopamine receptor form deprivation myopia

收稿日期: 2020-09-02

PACS:

基金资助: 四川省青年科技创新研究团队专项计划（2017TD0030）

通讯作者: 路雪婧（ORCID：0000-0001-5324-4736），Email：luxuejing@cdutcm.edu.cn

引用本文:

张曦文1，2 刘瑞宝1，2 宋冰洁1，2 刘玉玲1，2 吴玉坤1，2 路雪婧1，2，3，4，5. 多巴胺在形觉剥夺性近视中作用的研究进展[J]. 中华眼视光学与视觉科学杂志, 2021, 23(5): 396-400. Xiwen Zhang1, 2, Ruibao Liu1, 2, Bingjie Song1, 2, Yuling Liu1, 2, Yukun Wu1, 2, Xuejing Lu1, 2, 3, 4, 5. Research Progress in the Role of Dopamine in Form Deprivation Myopia. Chinese Journal of Optometry Ophthalmology and Visual science, 2021, 23(5): 396-400. DOI: 10.3760/cma.j.cn115909-20200902-00351

链接本文:

https://www.cjoovs.com/CN/10.3760/cma.j.cn115909-20200902-00351 或 https://www.cjoovs.com/CN/Y2021/V23/I5/396

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