Objective: To observe the effect of posterior chamber intraocular lens (ICL) implantation on retinal
blood flow density and retinal thickness in high myopia using optical coherence tomography angiography
(OCTA). Methods: This was a prospective clinical study. Twenty-five patients (43 eyes) who underwent
ICL implantation from December 2019 to may 2020 in the Affiliated Eye Hospital of Nanjing Medical
University were selected. The spherical equivalent (SE) was >-6.00 D. Visual acuity, intraocular pressure,
arch height, macular blood flow density and retinal thickness were measured before the operation and
1 week, 1 month and 3 months after the operation. The data were analyzed with repeated measures ANOVA.visual acuity (BCVA, LogMAR) were statistically significant (F=500.975, P<0.001; F=16.032, P<0.001,
respectively), and all improved compared to the preoperative values (P<0.001). The macular foveal
retinal thickness (CRT) did not change significantly after surgery, but the area of the avascular zone (FAZ)
decreased significantly after surgery (all P<0.001), and difference between preoperative and postoperative
were statistically significant (P<0.001), respectively. There was no significant difference in superficial
retinal blood flow density in the fovea, parafovea, temporal, superior, nasal or inferior regions before the
operation, and 1 week, 1 month and 3 months after the operation. There was no significant difference in
the deep retinal blood flow density in the fovea, temporal, superior or inferior regions 1 week, 1 month
and 3 months after the operation, but the deep retinal blood flow density in the parafovea and nasal region
decreased after the operation (all P<0.05). Conclusions: According to the OCTA, ICL implantation has a
significant effect on deep nasal retinal blood flow density, and decreases the area of FAZ, however there is
no significant effect on other retinal blood flow and thickness parameters.
Results: The postoperative uncorrected visual acuity (UDVA, LogMAR) and postoperative best corrected
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