Abstract:Objective: To evaluate the agreement in measuring the anterior ocular segment in myopia using the OA-2000 and Sirius systems. Methods: In this case series study, OA-2000 and Sirius were used to measure the corneal white-to-white (WTW) distance, anterior chamber depth (ACD) and central corneal thickness (CCT) of the anterior segment of 112 subjects (224 eyes) with myopia. The subjects visited the Department of Ophthalmology, Shenzhen Hospital of Peking University from October 1 to October 31, 2020. A paired t test and Pearson correlation analysis were used to compare the difference and correlation between the two instruments, and the Bland-Altman method was used to evaluate their consistency. Results: The average horizontal corneal diameter (WTW) was 11.84±0.38 mm and 11.87±0.38 mm respectively by Sirius, OA-2000, which was a statistically significant difference (t=-3.66, P<0.001). The average anterior chamber depth (ACD) from the corneal endothelium to the anterior surface of the lens was 3.23±0.26 mm and 3.16±0.25 mm, which was a statistically significant difference (t=15.11, P<0.001). The average central corneal thickness (CCT) was 538±35 µm and 524±34 µm, which was a statistically significant difference (t=27.20, P<0.001). There were high correlations between the two instruments: WTW (r=0.97, P<0.001), ACD (r=0.96, P<0.001), and CCT (r=0.97, P<0.001). The 95% limits of agreement (LoA) between the devices for WTW, ACD, and CCT were -0.16-0.21 mm, -0.20-0.07 mm, and -29.1-1.1 µm using the Bland-Altman limits of agreement (LoA) method. Conclusions: The correlations between OA-2000 and Sirius in terms of measuring anterior segment parameters in myopia are excellent. Significant differences were detected in WTW, ACD and CCT, so they should not be directly substituted for each other
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