Abstract：Objective: To investigate the time of occurrence, clinical manifestations, rick factors, treatment process
and prognosis of noninfectious endophthalmitis after cataract surger. Methods: A total of 1004 patients
(1420 eyes) who underwent phacoemulsification combined with intraocular lens implantation were enrolled
in this retrospective study, from October 13 to November 19, 2020 in Department of Ophthalmology, Army
Medical Center of PLA. The perioperative medications, surgical of instrument, surgical procedures and
postoperativ procedures were analyzed in in patients with postoperative non-infectious endophthalmitis.
The time of onset, symptoms, signs, best-corrected visual acuity (BCVA) scores before and after treatment
of non-infectious endophthalmitis were observed. The patients with non-infectious endophthalmitis
and those without endophthalmitis were divided into inflammatory group and non inflammatory group,respectively. The data were analyzed by t-test and repeated measurement analysis of variance. Results:
Sixteen cases (21 eyes) of non-infectious endophthalmitis were enrolled, including 5 males (7 eyes) and 11
female (14 eyes), with an average age of 68.6±9.5 (54-83) years. During the perioperative period, all drugs
and instruments are free of violation. All disinfection products were qualified. The operation process was
standardized and no complications occurred during the surgry. The same brand and model of hydrophobic
acrylate intraocular lens were used in all patients with non-infectious endophthalmitis. The average onset
time was 23.3±9.7 days after surgery. Conjunctiva showed mixed hyperemia. The cornea was transparent.
The anterior chamber glitter was (+-+++). The anterior chamber cells was (++-+++). There was fibrinous
exudation in the anterior chamber in some patients. B-mode ultrasound showed varying degrees of vitreous
opacity. The detection of pathogenic microorganisms in aqueous humor and vitreous was negative in all
patients. Preoperative endothelial cell count and intraocular pressure were normal in both groups. There
were no statistically difference in corneal curvature and axial length between inflammatory and non-
inflammatory groups. The depth of anterior chamber in inflammatory group was significantly lower
than that in non inflammatory group (t=-2.55, P=0.010). Conclusion: In this study, non-infectious
endophthalmitis after cataract surgery was highly suspected to be related to the intraocular lens. After
active treatment, the inflammation was controlled and resolved.
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