Abstract：Objective: To explore the outcomes of penetrating canaloplasty (PCP) for open-angle glaucoma (OAG) coexisted with high myopia (HM). Methods: In this retrospective case series study, 28 consecutive cases (40 eyes) with OAG combined with HM which underwent penetrating canaloplasty between July 2018 to March 2022 in the Eye Hospital, Wenzhou Medical University and were followed up for≥1 year after surgery be collected. Among them, 26 cases (38 eyes) with smooth 360° penetration during surgery were included in the analysis. HM was defned as spherical equivalent refraction (SE) ≤-6.00 D or axial length>26 mm;the surgical success rate was defned as 6 mmHg≤intraocular pressure (IOP)≤21 mmHg with or without glaucoma medications (qualified success) and without glaucoma medications (complete success) more than 3 months after surgery. Other outcome measures included baseline characteristics, postoperative IOP, number of glaucoma medications and procedure-related complications. Generalized estimation equations were used to analyze postoperative IOP and medications, Wald χ2 test was used to obtain the test results, and the Bonferroni method was used for pairwise comparison between groups. Results: Atotal of 38 eyes in 26 patients with OAG combined with HM which successfully received PCP had been reviewed, including 17 males (25 eyes) and 9 females (13 eyes). The mean preoperative age was 35.0±14.6 years and were followed-up for a mean of 20.7±11.7 months. The mean preoperative axial length was 28.7±2.6 mm (range 25.7-35.6 mm) and the mean spherical equivalent refraction was -7.78±3.71 D. The mean preoperative IOPwas 33.1±11.6 mmHg on 3 (3, 4) glaucoma medications, which was decreased to 16.6±3.4 mmHg (Wald χ2=15.52, P<0.001) on 0 (0, 1) medications (Wald χ2=1.48, P=0.002) at 6 months and 16.2±3.6 mmHg (Wald χ2=20.07, P<0.001) on 0 (0, 1) medications (Wald χ2=9.87, P=0.001) at 12 months postoperatively. The qualifed success rate and complete success were achieved in 92% (35/38) and 58% (22/38) at 12 months, respectively. Early transient IOP elevation, hyphema and hypotony was documented in 16, 12 and 7 eyes, 1 of the eyes had ciliary body detachment and choroid detachment. Conclusion: For OAG eyes coexisted with HM, penetrating canaloplasty was safe and effective in the medium and long term on reducing IOP with a high success rate.
李金鑫, 叶雯青, 赵免, 等. 穿透性Schlemm管成形术治疗合并高度近视的开角型青光眼的疗效[J]. 中华眼视光学与视觉科学杂志, 2023, 25(9): 653-658.
Jinxin Li, Wenqing Ye, Mian Zhao, et al. Outcomes of Penetrating Canaloplasty in Open-Angle Glaucoma Coexisted with High Myopia. Chinese Journal of Optometry Ophthalmology and Visual science, 2023, 25(9): 653-658. DOI: 10.3760/cma.j.cn115909-20230316-00071
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