Abstract：Infammation, oxidative stress, pathological neovascularization, and apoptosis of retinal nerve cells play an important role in the development of retinal diseases. They are common pathogenic mechanisms in diseases such as age-related macular degeneration (AMD), retinitis pigmentosa (RP), diabetic retinopathy (DR), and retinopathy of prematurity (ROP). ω-3 long-chain polyunsaturated fatty acids (ω-3 LC-PUFAs), as important components of the retina, have been shown to have anti-infammatory and anti-oxidative stress effects, inhibit neovascularization, and promote neuronal cell survival. ω-3 LC-PUFAs and their derivatives are involved in many processes in the prevention and treatment of retinal diseases, and deeper investigation of their relationship with pathological mechanisms may provide potential targets for treatment. The purpose of this article is to review the therapeutic mechanisms of ω-3 LC-PUFAs and their derivatives in retinal diseases and the current research progress, with the aim of providing new therapeutic directions for retinal diseases with similar pathogenesis.
王捷, 韩国鸽, 韩泉洪. ω-3长链多不饱和脂肪酸治疗视网膜疾病的分子机制及研究现状[J]. 中华眼视光学与视觉科学杂志, 2023, 25(9): 715-720.
Jie Wang, Guoge Han, Quanhong Han. Macular Mechanism and Research Status of ω-3 Long-Chain Polyunsaturated FattyAcids in the Treatment of Retinal Diseases. Chinese Journal of Optometry Ophthalmology and Visual science, 2023, 25(9): 715-720. DOI: 10.3760/cma.j.cn115909-20220125-00041
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