Eye Hospital, Wenzhou Medical University, Glaucoma Research Institute, Wenzhou Medical University, National Clinical Research Center for Ocular Diseases, Wenzhou 325027, China
Abstract：Objective: To investigate the vision-related quality of life (VR-Qol) and its infuencing factors in patients with primary open-angle glaucoma (POAG), and to compare the association of VR-Qol with visual feld of patients' better eye and binocular integrated visual field (IVF). Methods: This cross-sectional study encompassed POAG patients who were under follow-up within the Wenzhou Glaucoma Progression Study (WGPS) between June 2021 and September 2022 were included. IVF was calculated from the visual feld of both the patients'right and left eyes using the binocular summation method. VR-Qol of POAG patients were assessed by the 25-Item National Eye Institute Visual Functional Questionnaire (NEI VFQ-25). Patients were divided into normal group and abnormal group according to the score of the scale. The effects of patients' sociodemographic data and clinical data on the VR-Qol were analyzed. Independent sample t-test, Mann Whitney U test and Chi-squorre test were used for inter group comparison. Univariate and multivariate Logistic regression were used to analyze the infuencing factors of VR-Qol. Results: Atotal of 116 POAG patients were included in the study, comprising 70 males and 46 females. The average age of the participants was 61.3±14.6 years. The NEI VFQ-25 has a total score of 88.86±9.44. Among the patients, 27 (23.3%) exhibited abnormal VR-Qol, while 89 (76.7%) demonstrated normal VR-Qol. Compared with the abnormal group, the normal group presented fewer drugs requirements (Z=-2.02, P=0.044), better vision (Z=-2.28, P=0.023), larger retinal never fber layer (RNFL) thickness (Z=-2.64, P=0.008) and ganglion cell plexiform layer (GCIPL) thickness (Z=-2.29, P=0.022). Additionally, the normal group exhibited less visual field mean deviation (MD) (Z=-4.03, P<0.001), and slower loss rate of visual field index (VFI) (Z=-2.92, P=0.004). However, there were no significant differences in age, gender, educational level, marriage, unilateral or bilateral glaucoma diagnosis, visual feld progression, follow-up frequency, glaucoma duration, family history of glaucoma, hypertension and diabetes.Among the POAG patients with abnormal VR-Qol, lower scores were noted in the subscales of general vision, role diffculties and driving. The VR-Qol in patients with POAG was positively correlated with binocular MD (r=0.36, P<0.001), better MD (r=0.30, P<0.001) and worse MD (r=0.31, P<0.001). VR-Qol exhibited a signifcant correlation with binocular MD (OR=1.16, confdence interval: 1.02-1.32, P=0.029), while the correlation with better eye MD was not statistically significant (OR=1.11, confidence interval: 1.00-1.23, P=0.063). Conclusions: POAG patients with abnormal VR-Qol encountered challenges related to general vision, role diffculties and driving. The visual feld MD is an independent risk factor to abnormal VR-Qol among POAG patients. Notably, when compared to the MD of the better eye, binocular MD can help identify patients who need intervention.
储锡中, 胡成钜, 陈德福, 等. 原发性开角型青光眼患者视觉相关生活质量状况及影响因素[J]. 中华眼视光学与视觉科学杂志, 2023, 25(10): 748-756.
Xizhong Chu, Chengju Hu, Defu Chen,et al. Vision-Related Quality of Life and Its Infuencing Factors in Patients with Primary Open-Angle Glaucoma. Chinese Journal of Optometry Ophthalmology and Visual science, 2023, 25(10): 748-756. DOI: 10.3760/cma.j.cn115909-20230320-00075
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