Objective To evaluate the safety,efficacy,and stability of the INTRACOR femtosecond laser-based intrastromalprocedure to treat presbyopia.Methods In a retrospective case-series study,the nondominant eye (28 eyes in 28 presbyopic cases) was treated with femtosecond laser based on the INTRACORE technique and comparisons were made before and after the operation for near and distance visual acuity,refractive error,intraocular pressure,endothelial cell density,corneal topography,contrast sensitivity,glare sensitivity and patient satisfaction.All patients were followed up for 6 months.Data were analyzed using paired t test or paired Wilcoxon rank sum test.Results All cases were uneventful.Mean distance visual acuity (VA) at 6 months postoperatively was 0.0 logMAR (range,0.2 to-0.1) compared to a preoperative VA of 0.0 logMAR (rauge,0.2 to-0.1).The difference was not significant.Mean near visual acuity at 6 months postoperatively was 0.25 logMAR (range,0.4 to 0.0) compared to 0.5 logMAR (range,1.0 to 0.3) preoperatively.The elevated postoperative value (6.25±1.74 lines) was significantly different than the preoperative value (t=18.66,P＜0.01).The mean values for spherical power,cylinder equivalent and spherical equivalent at 6 months postoperatively were-0.25 D (range,-0.75 to 0.25 D),0.0 D (range,-0.75 to 0.25 D) and-0.37 D (range,-0.75 to 0.25 D),respectively,compared to preoperative values of 0.5 D (range,-0.25 to 1.0 D),0.0 D (range,-0.5 to 0.0 D) and +0.25 D (range,-0.12 to 0.75 D),respectively.The differences before and after the operation were significant for both spherical power and spherical equivalent values (Z=-4.50,-4.57,both P＜0.01).However,there was no significant difference in the cylinder equivalent value before and after the operation.The INTRACORE treatment induced a slight myopic shift of-0.54 D and there were no significant differences for intraocular pressure,endothelial cell density,contrast sensitivity and glare sensitivity before and after the operation.The average score was 89±14 for the quality of life questionnaire at 6 months postoperatively.Conclusion Femtosecond laser-based treatment using the INTRACORE technique appears to improve near visual acuity in presbyopic patients but there was no apparent effect on distance visual acuity.Femtosecond laser-based treatment with the INTRACORE technique is safe and has good visual outcomes.