急性高眼压引起的视网膜功能改变及结构损伤研究进展

doi:10.3760/cma.j.issn.1674-845X.2014.12.015

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摘要

急性眼压升高是视力损伤的重要危险因素。目前高眼压动物模型已证明眼压升高可引起视网膜结构与功能由内向外逐层损伤。急性高眼压主要通过机械压迫和导致的微循环缺血引起细胞微环境改变，最终诱导视网膜神经节细胞凋亡。不同眼压梯度及持续时间对视功能和组织结构的损伤程度不同，但具体量化指标尚无结论。现主要对急性高眼压对视功能与结构影响的研究进展进行综述。

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	徐琼
	赵明威

关键词 ：高眼压, 视功能改变, 结构损伤

Abstract：

Acute intraocular pressure （IOP） elevation is one of the key conditions responsible for visual dysfunction. Several animal models have demonstrated that elevated IOP gradually induces retinal structure and function damage from the inside to the outside. Mechanical compression and ischemia contribute to the alteration of the cellular microenvironment， which eventually cause the apoptosis of retinal ganglion cells. Different levels and duration of IOP result in different degrees of functional and structural damage. This article reviews the progress in current research about the influence of acute IOP elevation on visual function and structure.

Key words： Ocular hypertension Visual function change Structure damage

通讯作者: 赵明威，Email：zhaomingwei@medmail.com.cn

引用本文:

徐琼,赵明威. 急性高眼压引起的视网膜功能改变及结构损伤研究进展[J]. 中华眼视光学与视觉科学杂志, 2014, 16(12): 764-768. Xu Qiong,Zhao Mingwei. Retinal function change and structural damage induced by acute intraocular pressure elevation. Chinese Journal of Optometry Ophthalmology and Visual science, 2014, 16(12): 764-768. DOI: 10.3760/cma.j.issn.1674-845X.2014.12.015

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https://www.cjoovs.com/CN/10.3760/cma.j.issn.1674-845X.2014.12.015 或 https://www.cjoovs.com/CN/Y2014/V16/I12/764

[1]	Turalba AV， Grosskreutz C. A review of current technology used in evaluating visual function in glaucoma[J]. Semin Ophthalmol，2010，25：309-316.
[2]	Poloschek CM， Bach M. Electrophysiological examination methods in glaucoma diagnostics[J]. Ophthalmologe，2012，109：358-363.
[3]	Fortune B， Burgoyne CF， Cull GA， et al. Structural and functional abnormalities of retinal ganglion cells measured in vivo at the onset of optic nerve head surface change in experimental glaucoma[J]. Invest Ophthalmol Vis Sci，2012，53： 3939-3950.
[4]	De Moraes CG， Liebmann JM， Ritch R， et al. Clinical use of multifocal visual-evoked potentials in a glaucoma practice： a prospective study[J]. Doc Ophthalmol，2012，125：1-9.
[5]	Tamada K， Machida S， Oikawa T， et al. Correlation between photopic negative response of focal electroretinograms and local loss of retinal neurons in glaucoma[J]. Curr Eye Res，2010，35：155-164.
[6]	Bowd C， Vizzeri G， Tafreshi A， et al. Diagnostic accuracy of pattern electroretinogram optimized for glaucoma detection[J]. Ophthalmology，2009，116：437-443.
[7]	Bach M， Ramharter-Sereinig A. Pattern electroretinogram to detect glaucoma： comparing the PERGLA and the PERG ratio protocols[J]. Doc Ophthalmol，2013，127：227-238.
[8]	Chan HH， Ng YF， Chu PH. Applications of the multifocal electroretinogram in the detection of glaucoma[J]. Clin Exp Optom，2011，94：247-258.
[9]	Bui BV， Edmunds B， Cioffi GA， et al. The gradient of retinal functional changes during acute intraocular pressure elevation [J]. Invest Ophthalmol Vis Sci，2005，46：202-213.
[10]	Marmor MF， Brigell MG， McCulloch DL， et al. ISCEV standard for clinical electrooculography （2010 update）[J]. Doc Ophthalmol，2011，122：1-7.
[11]	Bui BV， He Z， Vingrys AJ， et al. Using the electroretinogram to understand how intraocular pressure elevation affects the rat retina[J]. J Ophthalmol，2013，2013：262-467.
[12]	Kong YX， Crowston JG， Vingrys AJ， et al. Functional changes in the retina during and after acute intraocular pressure elevation in mice[J]. Invest Ophthalmol Vis Sci，2009，50：5732-5740.
[13]	Grozdanic SD， Sakaguchi DS， Kwon YH， et al. Functional characterization of retina and optic nerve after acute ocular ischemia in rats[J]. Invest Ophthalmol Vis Sci，2003，44：2597-2605.
[14]	Zhao Y， Yu B， Xiang YH， et al. Changes in retinal morphology， electroretinogram and visual behavior after transient global ischemia in adult rats[J]. PLoS One，2013，8：e65555.
[15]	Belforte N， Sande PH， de Zavalia N， et al. Ischemic tolerance protects the rat retina from glaucomatous damage[J]. PLoS One，2011，6：e23763.
[16]	Medeiros FA. Evaluating the optic nerve for glaucomatous progression[M]//The glaucoma book. New York： Springer，2010： 203-207.
[17]	Fortune B， Choe TE， Reynaud J， et al. Deformation of the rodent optic nerve head and peripapillary structures during acute intraocular pressure elevation[J]. Invest Ophthalmol Vis Sci，2011，52：6651-6661.
[18]	Morrison JC， Johnson EC， Cepurna W， et al. Understanding mechanisms of pressure-induced optic nerve damage[J]. Prog Retin Eye Res，2005，24：217-240.
[19]	Morrison JC， Johnson E， Cepurna WO. Rat models for glaucoma research[J]. Prog Brain Res，2008，173：285-301.
[20]	熊鲲，黄菊芳，童建斌，等. 急性大鼠眼高压诱导的不同缺血/再灌内层视网膜的变化[J]. 解剖学杂志，2005，28：46-49.
[21]	He Z， Bui BV， Vingrys AJ. The rate of functional recovery from acute IOP elevation[J]. Invest Ophthalmol Vis Sci，2006， 47：4872-4880.
[22]	Kong YX， Crowston JG， Vingrys AJ， et al. Functional changes in the retina during and after acute intraocular pressure elevation in mice[J]. Invest Ophthalmol Vis Sci，2009，50：5732-5740.
[23]	Bui BV， Batcha AH， Fletcher E， et al. Relationship between the magnitude of intraocular pressure during an episode of acute elevation and retinal damage four weeks later in rats[J]. PLoS One，2013，8：e70513.
[24]	Caprioli J， Varma R. Intraocular pressure： modulation as treatment for glaucoma[J]. Am J Ophthalmol，2011，152：340- 344.
[25]	Gessesse GW， Damji KF. Advanced glaucoma： management pearls[J]. Middle East Afr J Ophthalmol，2013，20：131-141.
[26]	Aoyama A， Ishida K， Sawada A， et al. Target intraocular pressure for stability of visual field loss progression in normal-tension glaucoma[J]. Jpn J Ophthalmol，2010，54：117-123.
[27]	Almasieh M， Wilson AM， Morquette B， et al. The molecular basis of retinal ganglion cell death in glaucoma[J]. Prog Retin Eye Res，2012，31：152-181.
[28]	Salinas-Navarro M， Alarcon-Martinez L， Valiente-Soriano FJ， et al. Ocular hypertension impairs optic nerve axonal transport leading to progressive retinal ganglion cell degeneration[J]. Exp Eye Res，2010，90：168-183.
[29]	Dai C， Khaw PT， Yin ZQ， et al. Structural basis of glaucoma： the fortified astrocytes of the optic nerve head are the target of raised intraocular pressure[J]. Glia，2012，60：13-28.
[30]	Nickells RW， Howell GR， Soto I， et al. Under pressure： cellular and molecular responses during glaucoma， a common neurodegeneration with axonopathy[J]. Annu Rev Neurosci，2012， 35：153-179.
[31]	Harwerth RS， Wheat JL， Fredette MJ， et al. Linking structure and function in glaucoma[J]. Prog Retin Eye Res，2010，29：249-271.
[32]	Vidal-Sanz M， Salinas-Navarro M， Nadal-Nicolas FM， et al. Understanding glaucomatous damage： anatomical and functional data from ocular hypertensive rodent retinas[J]. Prog Retin Eye Res，2012，31：1-27.
[33]	Liu X， Li M， Zhong YM， et al. Damage patterns of retinal nerve fiber layer in acute and chronic intraocular pressure elevation in primary angle closure glaucoma[J]. Int J Ophthalmol，2010，3：152-157.
[34]	骆荣江，葛坚. 兔眼视网膜各组织对高眼压不同易损性的研究[J]. 中华眼科杂志，2001，37：302-306.
[35]	Medeiros FA， Alencar LM， Zangwill LM， et al. The Relationship between intraocular pressure and progressive retinal nerve fiber layer loss in glaucoma[J]. Ophthalmology，2009，116：1125-1133.
[36]	Medeiros FA， Zangwill LM， Anderson DR， et al. Estimating the rate of retinal ganglion cell loss in glaucoma[J]. Am J Ophthalmol，2012，154：814-824.
[37]	Anderson DR， Cynader MS. Glaucomatous optic nerve cupping as an optic neuropathy[J]. Clin Neurosci，1997，4：274-278.
[38]	Sigal IA. An applet to estimate the IOP-induced stress and strain within the optic nerve head[J]. Invest Ophthalmol Vis Sci，2011，52：5497-5506.
[39]	Quigley HA， McKinnon SJ， Zack DJ， et al. Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in rats[J]. Invest Ophthalmol Vis Sci，2000，41： 3460-3466.
[40]	Kerr NM， Johnson CS， Zhang J， et al. High pressure-induced retinal ischaemia reperfusion causes upregulation of gap junction protein connexin43 prior to retinal ganglion cell loss [J]. Exp Neurol，2012，234：144-152.
[41]	Abbott CJ， Choe TE， Lusardi TA， et al. Evaluation of retinal nerve fiber layer thickness and axonal transport 1 and 2 weeks after 8 hours of acute intraocular pressure elevation in rats[J]. Invest Ophthalmol Vis Sci，2014，55：674-687.
[42]	Quaranta L， Katsanos A， Russo A， et al. 24-hour intraocular pressure and ocular perfusion pressure in glaucoma[J]. Surv Ophthalmol，2013，58：26-41.