Objective To investigate the effect of different surgical parameters including flap creation parameters and ablation parameters on the recovery of postoperative central corneal sensation following FS-LASIK. Methods This was a prospective experimental study. Thirty-two patients （64 eyes） with myopia who underwent femtosecond laser assisted LASIK were enrolled in this study. Each patient had the similar bilateral refractive conditions. During flap creation before ablation， the side-cut angle was randomly set at 90° in one eye and 150° in the other eye， and the flap thickness was set at 100 µm or 110 µm， and ablation parameters including optical treatment zone and ablation depth was caculated by the system. Analyze the impact factors using generalized linear model and then eyes were divided into 3 groups according to ablation depth： group I， less than 80 µm， group II， from 80 to 100 µm， group III， more than 100 µm. Central corneal sensation was measured preoperatively and at 1 week， 1 month and 3 months postoperatively using Cochet-Bonnet esthesiometer. Repeated measures ANOVA were used to analyze the data. Results Central corneal sensation at 1 week and 1 month postoperatively was related to ablation depth（B=-0.231， -0.247， P<0.05）， however， no correlation was found with ablation at 3 months after LASIK （B=-0.222， P>0.05） or at 1 week， 1 month and 3 months operatively with side-cut angles （B=-2.569， -3.993， -0.607， P>0.05） and flap thickness （B=-4.422， -11.058， -10.368， P>0.05） and optical treatment zone （B=-3.515， -11.510， -9.058， P>0.05）. Compared with preoperative data， central corneal sensation was reduced at 1 week， 1 month and 3 months postoperatively（F=250.322， P<0.05）， however， there was no significant differences among the three groups at different time points（F=2.092， P>0.05）. Conclusion Ablation depth but not different side-cut angles and flap thicknesses or optical treatment zone has effect on the recovery of corneal sensation postoperatively.
孙西宇,张芦燕,胡亮,余野,熊彦,崔雨昕,王勤美. 不同手术参数对飞秒激光LASIK术后角膜知觉恢复的影响[J]. 中华眼视光学与视觉科学杂志, 2015, 17(5): 275-279.
Sun Xiyu,Zhang Luyan,Hu Liang,Yu Ye,Xiong Yan,Cui Yuxin,Wang Qinmei. The effect of different surgical parameters on the recovery of corneal sensation following FS-LASIK. Chinese Journal of Optometry Ophthalmology and Visual science, 2015, 17(5): 275-279. DOI: 10.3760/cma.j.issn.1674-845X.2015.05.005
Li M， Zhao J， Shen Y， et al. Comparison of dry eye and corneal sensitivity between small incision lenticule extraction and femtosecond LASIK for myopia[J]. PLoS One，2013，8（10）： e77797.
Nassaralla BA， Mcleod SD， Boteon JE， et al. The effect of hinge position and depth plate on the rate of recovery of corneal sensation following LASIK[J]. Am J Ophthalmol，2005， 139（1）：118-124.
[6]
Barequet IS， Hirsh A， Levinger S. Effect of thin femtosecond LASIK flaps on corneal sensitivity and tear function[J]. J Refract Surg，2008，24（9）：897-902.
[7]
Hu L， Xie W， Liu J， et al. Tear menisci and corneal subbasal nerve density in patients after Laser In Situ Keratomileusis[J]. Eye Contact Lens，2015，41（1）：51-57.
[8]
Bragheeth MA， Dua HS. Corneal sensation after myopic and hyperopic LASIK： clinical and confocal microscopic study[J]. Br J Ophthalmol，2005，89（5）：580-585.
[9]
Kim WS， Kim JS. Change in corneal sensitivity following laser in situ keraomileusis[J]. J Cataract Refract Surg，1999，25（3）： 368-373.
Xie W， Zhang D， Chen J， et al. Tear menisci after laser in situ keratomileusis with mechanical microkeratome and femtosecond laser[J]. Invest Ophthalmol Vis Sci，2014，55（9）： 5806-5812.
Ahn H， Kim JK， Kim CK， et al. Comparison of laser in situ keratomileusis flaps created by 3 femtosecond lasers and a microkeratome[J]. J Cataract Refract Surg，2011，37（2）：349-357.
[16]
Knorz MC， Vossmerbaeumer U. Comparison of flap adhesion strength using the Amadeus microkeratome and the IntraLase iFS femtosecond laser in rabbits[J]. J Refract Surg，2008，24（9）： 875-878.
[17]
Knox Cartwright NE， Tyrer JR， Jaycock PD， et al. Effects of variation in depth and side cut angulations in LASIK and thin-flap LASIK using a femtosecond laser： a biomechanical study[J]. J Refract Surg，2012，28（6）：419-425.
[18]
Sun CC， Chang CK， Ma DH， et al. Dry eye after LASIK with a femtosecond laser or a mechanical microkeratome[J]. Optom Vis Sci，2013，90（10）：1048-1056.
[19]
Kung JS， Sales CS， Manche EE. Corneal sensation and dry eye symptoms after conventional versus inverted side-cut femtosecond LASIK： a prospective randomized study[J]. Ophthalmology，2014， 121（12）：2311-2316.
[20]
Mian SI， Li AY， Dutta S， et al. Dry eyes and corneal sensation after laser in situ keratomileusis with femtosecond laser flap creation effect of hinge position， hinge angle， and flap thickness[J]. J Cataract Refract Surg，2009，35（12）：2092-2098.
[21]
Lawrenson JG， Corbett MC， O′Brart DP， et al. Effect of beam variables on corneal sensitivity after excimer laser photorefractive keratectomy[J]. Br J Ophthalmol，1997，81（8）：686-690.
[22]
Nassaralla BA， McLeod SD， Nassaralla JJ Jr. Effect of myopic LASIK on human corneal sensitivity[J]. Ophthalmology，2003， 110（3）：497-502.
Erie JC， McLaren JW， Hodge DO， et al. Long-term corneal kerotoctye deficits after photorefractive keratectomy and laser in situ keratomileusis[J]. Trans Am Ophthalmol Soc，2005，103：56-68.
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