角膜胶原交联治疗真菌性角膜溃疡的临床疗效

doi:10.3760/cma.j.cn115909-20190916-00249

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Abstract Objective: To evaluate whether corneal collagen cross-linking improves the outcome of fungal keratitis. Methods: This was a retrospective clinical study. Patients (n=82) with fungal infected eyes were treated at Affiliated Xiamen Eye Center of Xiamen University, from November 2011 to December 2017. Corneal cross-linking was performed using the standard protocol after a multi-antifungal drug treatment failed to resolve the infection in patients. Main outcome measures: Clinical symptoms and corneal healing were examined using a slit lamp biomicroscope and an in vivo laser confocal microscope. Visual acuity improvement was also evaluated. Results: After 6 months to 3 years of follow-up, corneal scars eventually developed in 71 of 82 eyes. In 52 of 82 eyes, visual acuity improved. However, corneal melting was exacerbated and uncontrolled in 8 patients who immediately underwent corneal transplant surgery. In one patient, self-conjunctival transplantation was performed, and two others received a therapeutic corneal transplant due to recurrent inflammation and melting. Conclusions: Our results demonstrate that corneal collagen cross-linking is an effective procedure to manage patients afflicted with fungal keratitis.

Key words： corneal collagen crosslinking riboflavin fungal keratitis therapy outcome

Received: 16 September 2019

Fund:National Natural Science Foundation (81570815，81570816); Natural Science Foundation of Fujian Province (2015D013); Fujian Provincial Creative Foundation (2014-CXB-50); Research on Youth of Health and Family Planning in Fujian Province (2017-2-117); Xiamen Research Program of Science and Technology (3502Z20174003); Xiamen National/Province Compatible Foundation (2013S0226)

Corresponding Authors: Huping Wu, Affiliated Xiamen Eye Center of Xiamen University, Xiamen 361001, China (Email: wuhuping123@163.com)

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https://www.cjoovs.com/EN/10.3760/cma.j.cn115909-20190916-00249 OR https://www.cjoovs.com/EN/Y2020/V22/I8/568

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