TgAPPswePS1转基因鼠视网膜的功能损伤和Aβ斑块沉积
The Accumulation of Aβ Deposits in the Retinas of APPswe/PS1 Transgenic Mice with Retinal Functional Degeneration
Zhizhang Dong1 , Juan Li2 , Xuerong Sun3 , Jian Ge4
TgAPPswePS1转基因鼠视网膜的功能损伤和Aβ斑块沉积 |
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董志章, 李娟, 孙雪荣, 葛坚 |
The Accumulation of Aβ Deposits in the Retinas of APPswe/PS1 Transgenic Mice with Retinal Functional Degeneration |
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Zhizhang Dong
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| APP与Aβ蛋白在视网膜上的免疫反应 A:对照组的APP免疫组织化学染色图,PBS代替一抗;B:APP在实验组视网膜内的阳性表达,呈弥散聚集,箭头所示;C:对照组视网膜切片Aβ无阳性表达;D:实验组视网膜切片上Aβ呈阳性免疫反应,箭头示Aβ蛋白弥散性表达,短箭示Aβ蛋白斑块样沉积。标尺:20μm。NFL,神经纤维层;INL,内颗粒层;IPL,内丛状层;ONL,外颗粒层;OPL,外丛状层;RPE,色素上皮细胞;APP,淀粉样前体蛋白;Aβ,淀粉样蛋白 |
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