Department of Ophthalmology, Xiangya Hospital of Central South University, Changsha 410008, China Yueyang Vocational & Technical College, Yueyang 414000, China
Objective: To measure and analyze higher-order aberrations (HOAs) and optical performance in patients with age-related cataract and in normal subjects. Methods: In this case control study, 36 eyes of 27 patients with age-related cataract were recruited from the outpatient clinics of Xiangya Hospital from October 2013 to July 2014. Optical performance was evaluated in terms of the root means square (RMS), Strehl ratio (SR),and modulation transfer function (MTF) for the central 3.0-mm pupil diameter. For comparison, 30 eyes of 17 subjects with no lenticular opacity (control group) were recruited and assessed in an identical manner.Statistical analyses were performed with independent samples t-tests. Results: There were no significant differences between the two groups for spherical equivalent (SE), corneal radius of curvature (CR), and Q-value. The age-related cataract group had significantly greater internal and ocular HOA RMSs than the control group (t=8.073, 7.321, P<0.001) for both, but the differences in corneal HOAs were not significant.The interal and ocular SR for the age-related cataract group were significantly less than for the control group (t=10.635, 9.039, P<0.001), but the differences in corneal SR were not significant. The internal and ocular MTFs for the age-related cataract group were significantly less than for the control group (t=8.325,7.034, P<0.001 for both). The corneal MTFs were not significantly different between the two groups.Conclusions: The internal and ocular SR, and MTF were significantly lower in patients with cataracts than in normal subjects. The internal and ocular HOAs were significantly higher in patients with cataracts than in normal subjects, while differences in corneal HOAs and optical metrics were not significant.
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