1 The First Affiliated Hospital of Jinan University, Guangzhou 510630, China 2 Jinan University, Guangzhou 510632, China 3 KTJR Laboratory, Guangzhou 510700, China
Abstract: Objective: To study the change in intraocular pressure with different positions of gaze in myopia groups. Methods: This was a series case study of myopic subjects who were recruited in Jinan University from December 2019 to January 2020. They were divided into three groups: Low myopia, moderate myopia and high myopia according to the spherical equivalent (SE). Routine eye examinations were performed, includimg axial length (AL), anterior chamber depth (ACD), central corneal thickness (CCT), corneal curvature K1-value (K1) and corneal curvature K2-value (K2). The iCare rebound tonometer was used to obtain the primary intraocular pressure (IOPP) in the relaxed state and the average binocular intraocular pressure at 9 different positions of gaze after 5 minutes (including convergence, upward, downward, leftward, rightward, left upward, left downward, right upward and right downward). Subjects rested for 5 minutes after testing at each position of gaze. An independent t-test, analysis of variance and association analysis were used to analyze data. Results: A final 60 volunteers (60 eyes) were involved in the study, including 21 eyes, 28 eyes, and 11 eyes in the low, moderate, and high myopia groups, respectively. There was no significant difference in data between the two eyes so the right eye was chosen in this study (t=0.835, P=0.406). There was a statistically significant difference in AL and spherical equivalent (SE) among the three groups (F=139.789, P<0.001; F=21.917, P<0.001). But there was no significant difference in the remaining parameters. After 5 minutes of gazing, there was no significant difference in the change in intraocular pressure between the three groups at the nine positions of gaze. No statistically significant correlations were observed in the three groups between the IOPP or intraocular pressure during the downward gaze position (IOPD) and SE. The correlation between IOPP and AL was not statistically significant in the three groups. No statistically significant correlations were observed in the low or moderate myopia groups between IOPC (convergence) and SE, contrary to high myopia (r=0.713, P=0.014). Conclusions: There is no difference in intraocular pressure between positions of gaze and primary intraocular pressure. There is no correlation between primary intraocular pressure and myopia in this study, but high myopes are advised to avoid spending long periods of time on near vision work.
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