Abstract: In recent years, diabetes-related complications have received increasing attention, mainly affecting the cornea and retina in the eye. The popularity of vitrectomy has caused concern of diabetic keratopathy. Hyperglycemia can affect corneal hierarchy by changing corneal morphology, metabolism and physiology, affecting the corneal epithelium, corneal nerve, tear film, and even the normal function of corneal endothelium and conjunctiva, leading to corneal epithelial elongation, persistent edema, recurrent erosion, decreased corneal nerve sensitivity, and tear film changes. This paper mainly discusses the morphological and pathological changes of diabetic keratopathy, the related pathogenesis and the experimental therapeutic agents currently under research, hoping to be helpful for clinical treatment.
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