Abstract： Objective: To investigate the clinical characteristics of Moraxella keratitis and the drug resistance of isolated strains. Methods: Retrospective study. From December 2013 to June 2020, 16 patients diagnosed with Moraxella keratitis in the Eye Hospital, Wenzhou Medical University were recruited. The clinical characteristics, risk factors, treatment effect, distribution of pathogenic bacteria and drug resistance were analyzed in this study. The drug resistance trend was analyzed, and the Moraxella species were identified with the semi-automatic identification instrument ATB Reader and the mass spectrometer MBT. Results: The 16 cases of Moraxella keratitis studied were all confirmed cases after laboratory examination. According to the analysis of clinical characteristics, previous eye surgery and diabetes/hypertension were the most common local and systemic risk factors. The most common presenting complaint of patients was eye pain, and the most common examination result was corneal ulcer. Laboratory examination revealed that there were 7 cases of Moraxella lacunarum, 4 cases of Moraxella nonliquifaciens, 3 cases of Moraxella osloensis, 1 case of Moraxella catarrhalis, 1 case of Moraxella atalantae. The drug sensitivity test showed that the pathogenic bacteria isolated were rarely resistant to penicillin, cephalosporin, tetracycline, quinolones, aminoglycosides, etc. Conclusions: In this study of 16 cases of Moraxella keratitis patients, eye pain and corneal ulcers are the most common. The comparative analysis of different Moraxella bacteria suggests that in Moraxella keratitis cases, Moraxella lacunar and Moraxella nonliquefied are the two main infectious pathogens, and their isolates are highly sensitive to drugs.
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