巩膜细胞外基质在近视发生发展中的作用

doi:10.3760/cma.j.issn.1674-845X.2016.07.015

Abstract
Figure/Table
References (0)
Related Citation (15)

Download: PDF (3858 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract The sclera is the final target tissue in myopia. The biological and biomechanical changes in the extracellular matrix (ECM) during the onset and development of myopia are significant. Numerous studies confirm that the initial remodeling of scleral ECM is a key part in the progression of myopia. Exploring the scleral ECM remodeling mechanisms as well as the regulation of the ECM remodeling process to control myopia has become a hot topic. Recent research related to the scleral ECM in myopia is reviewed in this paper.

Key words： Sclera Extracellular matrix Myopia

Fund:Medical Guided Project Supported by Shanghai Municipal Science and Technology Commission (10411966200); Chinese Medicine Scientific Research Supported by Shanghai Municipal Health Bureau (2014JP015A)

Corresponding Authors: Zhu Huang, Email: drzhuhuang@163.com

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	Tian Tian
	Zhu Huang

Cite this article:

Tian Tian,Zhu Huang. Role of the scleral extracellular matrix in the development of myopia[J]. Chinese Journal of Optometry Ophthalmology and Visual science, 2016, 18(7): 443-445.

URL:

https://www.cjoovs.com/EN/10.3760/cma.j.issn.1674-845X.2016.07.015 OR https://www.cjoovs.com/EN/Y2016/V18/I7/443

[1]	McBrien NA, Jobling AI, Gentle A. Biomechanics of the sclera in myopia: extracellular and cellular factors[J]. Optom Vis Sci, 2009,86(1):E23-E30. DOI:10.1097/OPX.0b013e3181940669.
[2]	McBrien NA, Cornell LM, Gentle A. Structural and ultrastructural changes to the sclera in a mammalian model of high myopia[J]. Invest Ophthalmol Vis Sci,2001,42(10):2179-2187.
[3]	Curtin BJ, Teng CC. Scleral changes in pathological myopia[J].Trans Am Acad Ophthalmol Otolaryngol,1958,62(6):777-788,788-790.
[4]	Rada JA, Achen VR, Penugonda S, et al. Proteoglycan composition in the human sclera during growth and aging[J]. Invest Ophthalmol Vis Sci,2000,41(7):1639-1648.
[5]	McBrien NA, Gentle A. Role of the sclera in the development and pathological complications of myopia[J]. Prog Retin Eye Res,2003,22(3):307-338.
[6]	Birk DE, Fitch JM, Babiarz JP, et al. Collagen fibrillogenesis in vitro: interaction of types I and V collagen regulates fibril diameter[J]. J Cell Sci,1990,95(Pt 4):649-657.
[7]	Trier K, Olsen EB, Ammitzb?ll T. Regional glycosaminoglycans composition of the human sclera[J]. Acta Ophthalmol (Copenh), 1990,68(3):304-306.
[8]	Siegwart JT, Strang CE. Selective modulation of scleral proteoglycan mRNA levels during minus lens compensation and recovery[J]. Mol Vis,2007,13:1878-1886.
[9]	Moring AG, Baker JR, Norton TT. Modulation of glycosaminoglycan levels in tree shrew sclera during lens-induced myopia development and recovery[J]. Invest Ophthalmol Vis Sci,2007,48(7):2947-2956. DOI:10.1167/iovs.06-0906.
[10]	Lewis JA, Garcia MB, Rani L, et al. Intact globe inflation testing of changes in scleral mechanics in myopia and recovery[J]. Exp Eye Res,2014,127:42-48. DOI:10.1016/j.exer.2014.07.004.
[11]	张新,王超英,李涛,等. 实验性近视眼巩膜病理学与生物力学特性的改变[J]. 眼科新进展,2012,32(11):1017-1020.
[12]	Dotan A, Kremer I, Livnat T, et al. Scleral cross-linking using riboflavin and ultraviolet-a radiation for prevention of progressive myopia in a rabbit model[J]. Exp Eye Res,2014,127:190-195. DOI:10.1016/j.exer.2014.07.019.
[13]	Liu TX, Wang Z. Collagen crosslinking of porcine sclera using genipin[J]. Acta Ophthalmol,2013,91(4):e253-257. DOI:10.1111/aos.12172.
[14]	Nakanishi H, Yamada R, Gotoh N, et al. Absence of association between COL1A1 polymorphisms and high myopia in the Japanese population[J]. Invest Ophthalmol Vis Sci,2009,50(2):544-550. DOI:10.1167/iovs.08-2425.
[15]	Inamori Y, Ota M, Inoko H, et al. The COL1A1 gene and high myopia susceptibility in Japanese[J]. Hum Genet,2007,122(2):151-157. DOI:10.1007/s00439-007-0388-1.
[16]	纪风涛,周翔天,瞿佳. I型胶原基因与近视关系的研究进展[J]. 中华眼视光学与视觉科学杂志,2010,12(2):155-158. DOI:10.3760/cma.j.issn.1674-845X.2010.02.020.
[17]	Zhou X, Ji F, An J, et al. Experimental murine myopia induces collagen type Iα1 (COL1A1) DNA methylation and altered COL1A1 messenger RNA expression in sclera[J]. Mol Vis,2012,18:1312-1324.
[18]	龙琴,褚仁远. 巩膜细胞外基质及基质金属蛋白酶在近视发展中作用的研究进展[J]. 中华眼科杂志,2005,41(11):1047-1049. DOI:10.3760/j:issn:0412-4081.2005.11.024.
[19]	王淑然,叶俊杰,龙琴. 负透镜诱导豚鼠离焦性近视眼后部巩膜Ⅰ型胶原、基质金属蛋白酶-2及金属蛋白酶组织抑制因子-2的表达[J]. 中国医学科学院学报,2010,32(1):55-59,后插4. DOI: 10.3881/j.issn.1000-503X.2010.01.014.
[20]	邹蕾蕾,刘睿,刘红,等. MMPs激动剂和抑制剂对人巩膜成纤维细胞MMP-1/2以及Ⅰ型胶原表达的作用研究[J]. 中国眼耳鼻喉科杂志,2013,13(2):91-95. DOI:10.3969/j.issn.1671-2420.2013.02.008.
[21]	胡守龙,崔冬梅,于刚,等. 胶原相关整合素对人巩膜成纤维细胞增殖和胶原合成的影响[J]. 眼科新进展,2013,33(6):501-504.
[22]	Tian XD, Cheng YX, Liu GB, et al. Expressions of type I collagen, α2 integrin and β1 integrin in sclera of guinea pig with defocus myopia and inhibitory effects of bFGF on the formation of myopia[J]. Int J Ophthalmol,2013,6(1):54-58. DOI: 10.3980/j.issn.2222-3959.2013.01.11.
[23]	周翔天,张立华,吕帆,等. 毒蕈碱受体Ⅰ型受体在人眼巩膜成纤维细胞中的表达[J]. 中华眼科杂志,2005,41(11):995-999. DOI: 10.3760/j:issn:0412-4081.2005.11.009.
[24]	Barathi VA, Kwan JL, Tan QS, et al. Muscarinic cholinergic receptor (M2) plays a crucial role in the development of myopia in mice[J]. Dis Model Mech,2013,6(5):1146-1158. DOI:10.1242/dmm.010967.
[25]	Zou L, Liu R, Zhang X, et al. Upregulation of regulator of G-protein signaling 2 in the sclera of a form deprivation myopic animal model[J]. Mol Vis,2014,20:977-987.
[26]	Overall CM, Wrana JL, Sodek J. Independent regulation of collagenase, 72-kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-beta[J]. J Biol Chem,1989,264(3):1860-1869.
[27]	Cutroneo KR, White L, Phan SH, et al. Therapies for bleomycin induced lung fibrosis through regulation of TGF-beta1 induced collagen gene expression[J]. J Cell Physiol,2007,211(3):585-589. DOI:10.1002/jcp.20972.
[28]	吴文灿. TGF-β1介导的MMP-2酶活性调控机制在FDM巩膜重塑中的作用[D]. 长沙:中南大学,2004.
[29]	Li HH, Huo LJ, Gao ZY, et al. Regulation of scleral fibroblast differentiation by bone morphogenetic protein-2[J]. Int J Ophthalmol,2014,7(1):152-156. DOI:10.3980/j.issn.2222-3959.2014.01.28.
[30]	Wang Q, Zhao G, Xing S, et al. Role of bone morphogenetic proteins in form-deprivation myopia sclera[J]. Mol Vis,2011,17:647-657.
[31]	Shelton L, Rada JA. Inhibition of human scleral fibroblast cell attachment to collagen type I by TGFBIp[J]. Invest Ophthalmol Vis Sci,2009,50(8):3542-3552. DOI:10.1167/iovs.09-3460.

[1]

Chinese Optometric Association, Chinese Ophthalmological Society; Ophthalmology and Optometry Committee, Ophthalmologists Association, Chinese Doctor Association; et al. Expert Consensus on Multifocal Soft Contact Lens Fitting for Myopia Control (2023)[J]. Chinese Journal of Optometry Ophthalmology and Visual science, 2023, 25(8): 561-567.