|
|
|
| The effects of different displays on the isolated-check VEP andpattern VEP |
| ZHAO Guanhua,CHEN Tao,DING Yifeng,SUN Kai,YAN Weiming,WU Fei,ZHANG Zuoming |
| Department of Clinical Aerospace Medicine, the Fourth Military Medical University, Xi′an 710032, China; 2. Cadet Brigade,the Fourth Military Medical University, Xi′an 710032, China |
|
|
|
|
Abstract Objective To compare the effects of liquid crystal display (LCD) and organic light emitting diode (OLED) on the pattern visual evoked potential (PVEP) and the isolated-check visual evoked potential (icVEP). Methods In this self control study, 8 healthy male volunteers (16 eyes), aged 22.1±3.0 years, were recruited to measure PVEPs and icVEPs using the Neucodia Visual Electrophysiological Diagnostic Systems with either the LCD or the OLED． The test sequences of different displays and test items were random． All measurements were performed by the same examiner． Paired t-tests were used to compare the results of the two systems． Results Compared with LCD, the OLED-measured P100 amplitudes of the PVEPs, including 4.8 cpd, 3.2 cpd, 2.4 cpd, and 1.2 cpd, improved significantly (OD: t=2.554, 2.785, 2.508, 2.982; OS: t=3.496, 3.148, 3.954, 2.786; all P＜0.05)．Compared with LCD, the OLED-measured P100 latencies decreased (OD: t=-7.985, -5.069, -14.145, -9.466, OS: t=-9.186, -6.470, -14.700, -22.454, all P＜0.01) as did the N75 (spatial frequencies: 4.8 cpd, 3.2 cpd, 2.4 cpd; OD: t=6.448, 5.181, 3.411; OS: t=8.973, 4.730, 7.937, all P＜0.05） and N135 (OD: t=3.042, 2.576, 6.859; OS: t=3.989, 3.304, 4.657, all P＜0.05） latencies (all P＜0.05)． There were no differences between LCD and OLED for latencies for N75 and N135 (all P＞0.05)． The signal-to-noise ratios of the icVEPs measured by OLED were significantly better than for LCD (OD: t=3.879; OS: t=2.981; both P＜0.05)． Conclusion Different displays have distinct effects on PVEP and icVEP． Strong visual electrophysiological signals were easier to evoke by OLED． It is necessary to set up a corresponding reference value for each display and to record the distinctions between them when analyzing the results of visual electrophysiological examinations．
|
|
Received: 15 December 2016
|
|
Corresponding Authors:
ZHANG Zuoming, Email: zhangzm@fmmu.edu.cn
|
|
|
|
| [1] |
Creel DJ. Visually Evoked Potentials. The Organization of retina and visual system[M]. Webvision, 1995. http://webvision.med.utah.edu/book/electrophysiology/visually-evoked-potentials/[2015- 07-14](2017-01-02).
|
| [2] |
Victor JD, Mast J. A new statistic for steady-state evoked potentials[J]. Electroencephalogr Clin Neurophysiol, 1991, 78(5):378-388.
|
| [3] |
Zemon V, Tsai JC, Forbes M, et al. Novel electrophysiological instrument for rapid and objective assessment of magnocellular deficits associated with glaucoma[J]. Doc Ophthalmol, 2008, 117(3): 233-243. DOI: 10.1007/s10633-008-9129-6.
|
| [4] |
Greenstein VC, Seliger S, Zemon V, et al. Visual evoked potential assessment of the effects of glaucoma on visual subsystems[J]. Vision Res, 1998, 38(12): 1901-1911.
|
| [5] |
Matsumoto CS, Shinoda K, Matsumoto H, et al. Liquid crystal display screens as stimulators for visually evoked potentials: flash effect due to delay in luminance changes[J]. Doc Ophthalmol, 2013, 127(2): 103-112. DOI: 10.1007/s10633-013- 9387-9.
|
| [6] |
Nagy BV, Gemesi S, Heller D, et al. Comparison of pattern VEP results acquired using CRT and TFT stimulators in the clinical practice[J]. Doc Ophthalmol, 2011, 122(3): 157-162. DOI:10.1007/s10633-011-9270-5.
|
| [7] |
Karanjia R, Brunet DG, Ten HM. Optimization of visual evoked potential (VEP) recording systems[J]. Can J Neurol Sci, 2009, 36(1): 89-92.
|
| [8] |
Livingstone MS, Hubel DH. Do the relative mapping densities of the magno- and parvocellular systems vary with eccentricity?[J]. J Neurosci, 1988, 8(11): 4334-4339.
|
| [9] |
Bullier J. Integrated model of visual processing[J]. Brain Res Rev, 2001, (2-3): 96-107.
|
| [10] |
Livingstone MS, Hubel DH. Psychophysical evidence for separate channels for the perception of form, color, movement, and depth[J]. J Neurosci, 1987, 7(11): 3416-3468.
|
| [11] |
Field G, Chichilnisky E. Information processing in the primate retina: circuitry and coding[J]. Annu Rev Neurosci, 2007, 30: 1- 30. DOI: 10.1146/annurev.neuro.30.051606.094252.
|
| [12] |
Fechtner RD, Weinreb RN. Mechanisms of optic nerve damage in primary open angle glaucoma[J]. Surv Ophthalmol, 1994, 39(1): 23-42.
|
| [13] |
Wen W, Zhang P, Liu T, et al. A Novel motion-on-color paradigm for isolating magnocellular pathway function inpreperimetric glaucoma[J]. Invest Ophthalmol Vis Sci, 2015, 56(8): 4439-4446. DOI: 10.1167/iovs.15-16394.
|
| [14] |
Zhang P, Wen W, Sun X, et al. Selective reduction of fMRI responses to transient achromatic stimuli in the magnocellular layers of the LGN and the superficial layer of the SC of early glaucoma patients[J]. Hum Brain Mapp, 2016, 37(2): 558-569. DOI: 10.1002/hbm.23049.
|
| [15] |
Ito Y, Shimazawa M, Chen YN, et al. Morphological changes in the visual pathway induced by experimental glaucoma in Japanese monkeys[J]. Exp Eye Res, 2009, 89(2): 246-255. DOI:10.1016/j.exer.2009.03.013.
|
| [16] |
Giuffrè I. Frequency Doubling Technology vs Standard Automated Perimetry in Ocular Hypertensive Patients[J]. Open Ophthalmol J, 2009, 36-39. DOI: 10.2174/1874364100903010006.
|
| [17] |
Barboni MT, Pangeni G, Ventura DF, et al. Heterochromatic flicker electroretinograms reflecting luminance and cone opponent activity in glaucoma patients[J]. Invest Ophthalmol Vis Sci, 2011, 52(9): 6757-6765. DOI: 10.1167/iovs.11-7538.
|
| [18] |
Schmeisser ET, Smith TJ. High-frequency flicker visual-evoked potential losses in glaucoma[J]. Ophthalmology, 1989, 96(5): 620- 623.
|
|
|
|
