|
|
|
| Comparison of Pseudoexfoliation Open Angle Glaucoma and Primary Open Angle Glaucoma in Anterior Segment Structure Parameters |
| Fan Li1, Guangxian Tang1, Qingli Shang2, Hengli Zhang1, Xiaowei Yan1, Lihua Ma1, Yulei Geng1, Qing Zhang1 |
1Department of Ophthalmology, the First Hospital of Shijiazhuang, Shijiazhuang 050000, China
2Department of Ophthalmology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China |
|
|
|
|
Abstract Objective: To analyze and compare the differences of anterior segment structure parameters between pseudoexfoliation open angle glaucoma (PXOAG) and primary open angle glaucoma (POAG). Methods: This clinical case control study was conducted from December 2012 to December 2016, and the patients
were selected consecutively. The PXOAG group included 54 eyes of 54 cases with an average intraocular pressure of 28.8±7.9 mmHg. The POAG group included 53 eyes of 53 cases that were matched for age,gender, and intraocular pressure, 26.3±7.4 mmHg. Anterior segment structure parameters such as corneal thickness, corneal endothelial cell density, hexagonality, anterior chamber depth, and lens thickness were measured and analyzed using independent samples t -tests. Results: For the PXOAG group, the central corneal thickness (523±41 μm), hexagonality (52%±14%), anterior chamber depth (2.79±0.60 mm), and lensthickness (4.98±0.42 mm) were not significantly different from the POAG group (t =1.57, 0.18, 1.11, 0.26, respectively, P >0.05 each). However, the corneal endothelial cell density of the PXOAG group (2 323± 451/mm2) was significantly lower than that of the POAG group (2 538±356/mm2; t=2.78, P=0.01). Conclusions: The corneal endothelial cell density of POXG patients is lower than that of POAG patients. This is a reminder to pay more attention to the protection of corneal endothelial cells during clinical treatment.
|
|
Received: 22 March 2017
|
|
Corresponding Authors:
Guangxian Tang, the First Hospital of Shijiazhuang, Shijiazhuang 050000, China
(Email: gxtykyy@126.com)
|
|
|
|
| [1] |
Ritch R, Schlötzer-Schrehardt U. Exfoliation syndrome. Surv Ophthalmol, 2001, 45(4): 265-315.
|
| [2] |
PrskaloMŠ,Tomi??,Novak-LaušK,etal.Correlationbetween macular changes in exfoliation syndrome and exfoliative glaucoma. Acta Clin Croat, 2016, 55(1): 87-92.
|
| [3] |
Karger RA, Jeng SM, Johnson DH, et al. Estimated incidence of pseudoexfoliation syndrome and pseudoexfoliation glaucoma in Olmsted County, Minnesota. J Glaucoma, 2003, 12(3): 193-197.
|
| [4] |
Ritch R. Exfoliation syndrome-the most common identifiable cause of open-angle glaucoma. J Glaucoma, 1994, 3(2): 176-177.
|
| [5] |
中华医学会眼科学分会青光眼学组. 我国原发性青光眼诊断和治疗专家共识（2014年）. 中华眼科杂志, 2014, 50(5): 382 -383. DOI: 10.3760/cma.j.issn.0412-4081.2014.05.022.
|
| [6] |
Heijl A, Bengtsson B, Hyman L, et al. Natural history of open-angle glaucoma. Ophthalmology, 2009, 116(12): 2271-2276. DOI: 10.1016/ j.ophtha.2009.06.042.
|
| [7] |
Ritch R, Schlötzer-Schrehardt U, Konstas AG. Why is exfoliation syndrome associated with glaucoma? Prog Retin Eye Res, 2003, 22(3): 253-275. DOI: 10.1016/S1350-9462(02)00014-9.
|
| [8] |
Vesti E, Kivelä T. Exfoliation syndrome and exfoliation glaucoma. Prog Retin Eye Res, 2000, 19(3): 345-368.
|
| [9] |
Teus MA, Castejón MA, Calvo MA, et al. Intraocular pressure as a risk factor for visual field loss in pseudoexfoliative and in primary open-angle glaucoma. Ophthalmology, 1998, 105(12): 22252229; discussion 2229-2230. DOI: 10.1016/S0161-6420(98)91220-9.
|
| [10] |
Ritch R. Cataract and exfoliative glaucoma. J Glaucoma, 1998, 7(3): 178-181.
|
| [11] |
Osher RH, Cionni RJ, Gimbel HV, et al. Cataract surgery in patients with pseudoexfoliation syndrome. J Cataract Refract Surg, 1993, 5(1): 46-50. DOI:10.1016/S0955-3681(13)80062-7.
|
| [12] |
Küchle M, Viestenz A, Martus P, et al. Anterior chamber depth and complications during cataract surgery in eyes with pseudoexfoliation syndrome. Am J Ophthalmol, 2000, 129(3): 281-285.
|
| [13] |
Inoue K, Okugawa K, Oshika T, et al. Morphological study of corneal endothelium and corneal thickness in pseudoexfoliation syndrome. Jpn J Ophthalmol, 2003, 47(3): 235-239.
|
| [14] |
Hepsen IF, Ya?ci R, Keskin U. Corneal curvature and central corneal thickness in eyes with pseudoexfoliation syndrome. Can J Ophthalmol, 2007, 42(5): 677-680. DOI: 10.3129/i07-145.
|
| [15] |
Puska P, Vasara K, Harju M, et al. Corneal thickness and corneal endothelium in normotensive subjects with unilateral exfoliation syndrome. Graefes Arch Clin Exp Ophthalmol, 2000, 238(8): 659-663. DOI: 10.1007/s004170000159.
|
| [16] |
Cankaya AB, Anayol A, Özcelik D, et al. Ocular response analyzer to assess corneal biomechanical properties in exfoliation syndrome and exfoliative glaucoma. Graefes Arch Clin Exp Ophthalmol, 2012, 250(2): 255-260. DOI: 10.1007/s00417-011-1793-7.
|
| [17] |
de Juan-Marcos L, Cabrillo-Estévez L, Escudero-Domínguez FA, et al. Morphometric changes of corneal endothelial cells in pseu doexfoliation syndrome and pseudoexfoliation glaucoma. Arch Soc Esp Oftalmol, 2013, 88(11): 439-444. DOI: 10.1016/ j.oftal.2013.06.010.
|
| [18] |
Layden WE, Shaffer RN. Exfoliation syndrome. Am J Ophthalmol, 1974, 78(5): 835-841.
|
| [19] |
杨瑾, 孙慧敏, 袁佳琴. 剥脱综合征. 中国实用眼科杂志, 2000, 18(12): 739-742. DOI: 10.3760/cma.j.issn.1006-4443. 2000.12.001.
|
| [20] |
Asano N, Schlötzer-Schrehardt U, Naumann GO. A histopathologic study of iris changes in pseudoexfoliation syndrome. Ophthalmology, 1995, 102(9): 1279-1290.
|
| [21] |
Gross FJ, Tingey D, Epstein DL. Increased prevalence of occludable angles and angle-closure glaucoma in patients with pseudoexfoliation. Am J Ophthalmol, 1994, 117(3): 333-336. DOI: 10.1016/S00029394(14)73141-1.
|
| [22] |
Gohdo T, Takahashi H, Iijima H, et al. Ultrasound biomicroscopy of angle closure glaucoma with pseudoexfoliation syndrome. Br J Ophthalmol, 1997, 81(8): 706-707.
|
| [23] |
Schlötzer-Schrehardt U, Naumann GO. A histopathologic study of zonular instability in pseudoexfoliation syndrome.Am J Ophthalmol, 1994, 118(6): 730-743.
|
| [24] |
丁琳, 王绍飞, 葛玉梅, 等. 维吾尔族剥脱综合征患者眼轴及中央前房深度与眼压的相关性研究. 中国眼耳鼻喉科杂志, 2013, 13(3): 170-172. DOI: 10.3969/j.issn.1671-2420.2013.03.011.
|
| [25] |
Doganay S, Tasar A, Cankaya C, et al. Evaluation of Pentacam-Scheimpflug imaging of anterior segment parameters in patients with pseudoexfoliation syndrome and pseudoexfoliative glaucoma. Clin Exp Optom, 2012, 95(2): 218-222. DOI: 10.1111/j.1444-0938. 2011.00691.x.
|
| [26] |
Yavas GF, Oztürk F, Küsbeci T, et al. Evaluation of the change in accommodation amplitude in subjects with pseudoexfoliation. Eye (Lond), 2009, 23(4): 822-826. DOI: 10.1038/eye.2008.143.
|
| [27] |
Beyazy?ld?z E, Beyazy?ld?z Ö, Günayd?n S, et al. Evaluation of optical low coherence reflectometry parameters in patients with exfoliation syndrome. J Ophthalmol, 2015, 2015: 658091. DOI: 10.1155/2015/658091.
|
| [28] |
Arnarsson A, Damji KF, Sverrisson T, et al. Pseudoexfoliation in the Reykjavik Eye Study: prevalence and related ophthalmological variables. Acta Ophthalmol Scand, 2007, 85(8): 822-827. DOI: 10.1111/ j.1600-0420.2007.01051.x.
|
| [29] |
Quiroga L, Lansingh VC, Samudio M, et al. Characteristics of the corneal endothelium and pseudoexfoliation syndrome in patients with senile cataract. Clin Exp Ophthalmol, 2010, 38(5): 449-455. DOI: 10.1111/j.1442-9071.2010.02313.x.
|
| [30] |
Niederer RL, Perumal D, Sherwin T, et al. Age-related differences in the normal human cornea: a laser scanning in vivo confocal microscopy study. Br J Ophthalmol, 2007, 91(9): 1165-1169. DOI: 10.1136/bjo.2006.112656.
|
| [31] |
Schlötzer-Schrehardt UM, Dörfler S, Naumann GO. Corneal endothelial involvement in pseudoexfoliation syndrome. Arch Ophthalmol chic, 1993, 111(5): 666-674.
|
| [32] |
Küchle M, Nguyen NX, Hannappel E, et al. The blood-aqueous barrier in eyes with pseudoexfoliation syndrome. Ophthalmic Res, 1995, 27 Suppl 1: 136-142.
|
| [33] |
Gagnon MM, Boisjoly HM, Brunette I, et al. Corneal endothelial cell density in glaucoma. Cornea, 1997, 16(3): 314-318.
|
| [34] |
Wilczynski M, Supady E, Loba P, et al. Comparison of early corneal endothelial cell loss after coaxial phacoemulsification through 1.8mmmicroincisionandbimanualphacoemulsification through 1.7 mm microincision. J Cataract Refract Surg, 2009, 35(9): 1570-1574. DOI: 10.1016/j.jcrs.2009.05.014.
|
|
|
|
