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| A Comparison of Corneal Topography between Subclinical Keratoconusand Simple High Myopic Astigmatism Using a Pentacam Analyzer |
| Qidi Hu,Lingli Xu,Dongqing Zhu,Zhe Zhang,Wei Mao,Yusheng Zhou,Qinbo Li |
| Refractive Surgery Center, the Ningbo Eye Hospital, Ningbo 315040, China |
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Abstract Objective: To evaluate the differential diagnosis between subclinical keratoconus and simple high myopic astigmatism by using a Pentacam anterior segment analyzer. Methods: Fifty eyes of 46 patients with subclinical keratoconus (Rabinowitz diagnosis standard) and 76 eyes of 52 patients with simple high myopic astigmatism (>2.5 diopter) were included in this retrospective case control study. A Pentacam was used to measure the anterior and posterior corneal elevation parameters, minimum pachymetry (MinPachy),the index of vertical asymmetry (IVA), the index of highest decentration (IHD), the average corneal thickness progression index, and the Belin D value of the Belin/Ambrosio Enhanced Ectasia Display. An independent samples t-test was used to analyze the differences between the two groups. Receiver operating characteristic (ROC) curves were used to screen the useful parameters and determine the best diagnosis point. Results: There were significant differences between the two groups for the anterior corneal elevation parameters (t=6.77, P<0.001), posterior corneal elevation parameters (t=9.00, P<0.001), MinPachy (t=3.12,P=0.002), IVA (t=8.35, P<0.001), IHD (t=8.94, P<0.001), the average corneal thickness progression indexes (t=5.59, P<0.001), and the D values of the Belin/Ambrosio Enhanced Ectasia Display (t=13.01, P<0.001). The posterior corneal elevation parameter and the D value of the Belin/Ambrosio Enhanced Ectasia Display had the highest relevance in the differential diagnosis between subclinical keratoconus and simple high myopic astigmatism (area under the ROC curve ≥ 0.9). Conclusion: Analyzing the corneal indexes of high myopic astigmatism contributes to the screening of subclinical keratoconus.
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Received: 15 February 2017
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| Fund: This study was funded by Ningbo Natural Science Foundation (2010A610033) |
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Corresponding Authors:
Qidi Hu, Refractive Surgery Center, the Ningbo Eye Hospital, Ningbo 315040,China(Email: huqidi2007@163.com)
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