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Research Progress on the Differences in the Structural and BiologicalParameters of the Eyeball between Rhesus Monkeys and Humans |
Bowen Ouyang,Fengju Zhang |
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology &Visual Sciences Key Lab, Beijing 100730, China |
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Abstract The rhesus monkey is a primate and has been widely used in the medical research field because its morphological anatomy and physiological functions are similar to humans. An extensive literature search was done in order to further understand the morphological, structural and anatomical differences between human
and rhesus monkey eyes. Based on the extensive literature search, this paper expounds on the similarities and differences between rhesus monkey and human eyes from the perspectives of the cornea, lens,retina, sclera, refractive parameters and intraocular pressure. The aim of this study is to provide a reference for research on the rhesus monkey as an experimental animal model for human visual system diseases.
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Received: 11 January 2017
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Fund: This study was funded by National Science Foundation of China (81570877,81271041), and Beijing Health System High level Technology Talent Fund (2013-2-023) |
Corresponding Authors:
Fengju Zhang, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing 100730, China (Email:wxw93@hotmail.com)
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|
[1] |
Harwerth RS, Smith EL. Rhesus monkey as a model for normal vision of humans. Am J Optom Physiol Opt, 1985, 62(9): 633-641.
|
[2] |
叶智彰, 彭燕章, 张耀平. 猕猴解剖. 北京: 科学出版社, 1985:173-177.
|
[3] |
李凤鸣. 眼科全书. 北京: 人民卫生出版社, 1996: 124-168.
|
[4] |
王桂琴, 董亚利, 袁佳琴, 等. 猕猴眼球超微结构的研究. 眼科研究, 2000, 18(1): 25-27. DOI: 10.3760/cma.j.issn.2095-0160.2000.01.008.
|
[5] |
朱勤, 肖中男, 孙晓梅, 等. 超声乳化致恒河猴角膜内皮损伤动物模型的建立. 眼科新进展, 2013, 33(2): 110-112.
|
[6] |
唐娜, 徐锦堂. 灵长目动物角膜内皮细胞再生能力及方式的研究. 中华眼科杂志, 1998, (01): 28-30.
|
[7] |
Joyce NC, Meklir B, Joyce SJ, et al. Cell cycle protein expression and proliferative status in human corneal cells. Invest Ophthalmol Vis Sci, 1996, 37(4): 645-655.
|
[8] |
Patel SP, Bourne WM. Corneal endothelial cell proliferation:a function of cell density. Invest Ophthalmol Vis Sci, 2009, 50(6): 2742-2746. DOI: 10.1167/iovs.08-3002.
|
[9] |
刘良平, 王泳, 何淼, 等. 飞秒激光辅助猴眼角膜基质透镜移植观察. 中山大学学报(医学科学版), 2015, 36(3): 449-455.
|
[10] |
张和宁, 张敏, 黄勉, 等. 兔和猴眼表碱烧伤经人羊膜治疗性移植后的临床表现和病理变化观察. 临床眼科杂志, 2015, (5):452-455. DOI: 10.3969/j.issn.1006-8422.2015.05.022.
|
[11] |
Raskin E, Paula JS, Cruz AA, et al. Effect of bevel position on the corneal endothelium after phacoemulsification. Arq Bras Oftalmol, 2010, 73(6): 508-510.
|
[12] |
黄秀榕, 李志雄, 范春梅. 猕猴眼屈光间质及实用参数研究.福建中医学院学报, 1997, (02): 16-18. 1997, (02): 16-18.
|
[13] |
涂姝, 李康, 黄晶晶, 等. 恒河猴慢性高眼压模型视乳头和视神经纤维损伤模式. 中华眼视光学与视觉科学杂志, 2014, 16(7): 436-440. DOI: 10.3760/cma.j.issn.1674-845X.2014.07.012.
|
[14] |
Doughty MJ, Jonuscheit S. The orbscan acoustic (correction) factor for central corneal thickness measures of normal human corneas. Eye Contact Lens, 2010, 36(2): 106-115.
|
[15] |
祁明信, 吴翊钦, 陈莲英, 等. 猕猴白内障晶体上皮细胞超微结构研究. 中华眼科杂志, 1998, 34(5): 38-40. 1998, (5): 38-40.
|
[16] |
高福禄, 王仲涛, 吴淑兰, 等. 对人胎儿晶状体上皮的超微结构研究. 眼科研究, 1988, 6(4): 216-218.
|
[17] |
Marussich L, Manns F, Nankivil D, et al. Measurement of crystalline lens volume during accommodation in a lens stretcher.Invest Ophthalmol Vis Sci, 2015, 56(8): 4239-4248. DOI: 10.1167/iovs. 15-17050.
|
[18] |
Koretz JF, Bertasso AM, Neider MW, et al. Slit-lamp studies of the rhesus monkey eye: II. Changes in crystalline lens shape,thickness and position during accommodation and aging. Exp Eye Res, 1987, 45(2): 317-326
|
[19] |
孔祥梅, 孙兴怀, 俞道义, 等. 眼科常用实验动物视网膜血管的比较. 中国实验动物学报, 2007, 15(6): 416-418. DOI: 10.3969/j.issn.1005-4847.2007.06.005.
|
[20] |
Zhang Z, Yang D, Sang J, et al. Reproducibility of macular,retinal nerve fiber layer, and ONH measurements by OCT in Rhesus monkeys: The Beijing Intracranial and Intraocular Pressure(iCOP) Study. Invest Ophthalmol Vis Sci, 2012, 53(8): 4505-4509.
|
[21] |
Dichtl A, Jonas JB, Naumann GO. Retinal nerve fiber layer thickness in human eyes. Graefes Arch Clin Exp Ophthalmol,1999, 237(6): 474-479.
|
[22] |
Li JP, Wang XZ, Fu J, et al. Reproducibility of RTVue retinal nerve fiber layer thickness and optic nerve head measurements in normal and glaucoma eyes. Chin Med J (Engl), 2010, 123(14):1898-1903.
|
[23] |
Li J, Yang YQ, Yang DY, et al. Reproducibility of perfusion parameters of optic disc and macula in rhesus monkeys by optical coherence tomography angiography. Chin Med J (Engl),2016, 129(9): 1087-1090. DOI: 10.4103/0366-6999.180532.
|
[24] |
Yu J, Jiang C, Wang X, et al. Macular perfusion in healthy Chinese: an optical coherence tomography angiogram study.Invest Ophthalmol Vis Sci, 2015, 56(5): 3212-3217. DOI: 10.
|
11 |
67/iovs.14-16270.
|
[25] |
冷云霞, 饶志波, 匡丽晖, 等. 正常恒河猴闪光视网膜电图特点的研究. 国际眼科杂志, 2012, 12(7): 1263-1265. DOI: 10.3969/j.issn.1672-5123.2012.07.12.
|
[26] |
Gouras P, Ivert L, Neuringer M, et al. Topographic and agerelated changes of the retinal epithelium and Bruch's membrane of rhesus monkeys. Graefes Arch Clin Exp Ophthalmol, 2010, 248(7): 973-984. DOI: 10.1007/s00417-010-1325-x.
|
[27] |
Wing GL, Blanchard GC, Weiter JJ. The topography and age relationship of lipofuscin concentration in the retinal pigment epithelium. Invest Ophthalmol Vis Sci, 1978, 17(7): 601-607.
|
[28] |
Zhao T, Lu Q, Tao Y, et al. Effects of apelin and vascular endothelial growth factor on central retinal vein occlusion in monkey eyes intravitreally injected with bevacizumab: a
|
|
preliminary study. Mol Vis, 2011, 17: 1044-1055.
|
[29] |
李戴弟, 高云霞, 潘玲珍, 等. Lucentis和Avastin治疗激光诱导恒河猴脉络膜新生血管模型的作用. 眼科新进展, 2016, 36(5):423-427. DOI: 10.13389/j.cnki.rao.2016.0113.
|
[30] |
赖坤贝, 金陈进, 涂姝, 等. 激光诱导的恒河猴脉络膜新生血管模型的研究. 中华眼科杂志, 2014, 50(3): 203-208. DOI: 10.3760/cma.j.issn.0412-4081.2014.03.010.
|
[31] |
Downs JC, Suh JK, Thomas KA, et al. Viscoelastic characterization of peripapillary sclera: material properties by quadrant in rabbit and monkey eyes. J Biomech Eng, 2003, 125(1): 124-131.
|
[32] |
Girard MJ, Suh JK, Bottlang M, et al. Scleral biomechanics in the aging monkey eye. Invest Ophthalmol Vis Sci, 2009, 50(11):5226-5237. DOI: 10.1167/iovs.08-3363.
|
[33] |
Jackson TL, Hussain A, Hodgetts A, et al. Human scleral hydraulic conductivity: age-related changes, topographical variation, and potential scleral outflow facility. Invest Ophthalmol Vis Sci, 2006, 47(11): 4942-4946. DOI: 10.1167/iovs.06-0362.
|
[34] |
Girard MJ, Suh JK, Bottlang M, et al. Biomechanical changes in the sclera of monkey eyes exposed to chronic IOP elevations. Invest Ophthalmol Vis Sci, 2011, 52(8): 5656-5669. DOI: 10.1167/iovs. 10-6927.
|
[35] |
Bailey AJ. Structure, function and ageing of the collagens of the eye. Eye (Lond), 1987, 1( Pt 2): 175-183. DOI: 10.1038/eye.1987.34.
|
[36] |
廖爱平. 频闪光照对青少年期猴眼正视化过程的影响研究.广州: 中山大学, 2010.
|
[37] |
Raviola E, Wiesel TN. An animal model of myopia. N Engl J Med, 1985, 312(25): 1609-1615. DOI: 10.1056/NEJM198506203122505.
|
[38] |
Rymer J, Wildsoet CF. The role of the retinal pigment epithelium in eye growth regulation and myopia: a review. Vis Neurosci, 2005, 22(3): 251-261. DOI:10.1017/S0952523805223015.
|
[39] |
Norton TT, Siegwart JT. Animal models of emmetropization:matching axial length to the focal plane. J Am Optom Assoc,1995, 66(7): 405-414.
|
[40] |
Bradley DV, Fernandes A, Lynn M, et al. Emmetropization in the rhesus monkey (Macaca mulatta): birth to young adulthood. Invest Ophthalmol Vis Sci, 1999, 40(1): 214-229.
|
[41] |
Blomdahl S. Ultrasonic measurements of the eye in the newborn infant. Acta Ophthalmol (Copenh), 1979, 57(6): 1048-1056.
|
[42] |
Larsen JS. The sagittal growth of the eye. 1. Ultrasonic measurement of the depth of the anterior chamber from birth to puberty. Acta Ophthalmol (Copenh), 1971, 49(2): 239-262.
|
[43] |
Fernandes A, Bradley DV, Tigges M, et al. Ocular measurements throughout the adult life span of rhesus monkeys. Invest Ophthalmol Vis Sci, 2003, 44(6): 2373-2380.
|
[44] |
Hemenger RP, Garner LF, Ooi CS. Change with age of the refractive index gradient of the human ocular lens. Invest Ophthalmol Vis Sci, 1995, 36(3): 703-707.
|
[45] |
Ooi CS, Grosvenor T. Mechanisms of emmetropization in the aging eye. Optom Vis Sci, 1995, 72(2): 60-66.
|
[46] |
Klein BE, Klein R, Linton KL. Prevalence of age-related lens opacities in a population. The Beaver Dam Eye Study.Ophthalmology, 1992, 99(4): 546-552.
|
[47] |
Engel HM, Dawson WW, Ulshafer RJ, et al. Degenerative changes in maculas of rhesus monkeys. Ophthalmologica, 1988,196(3): 143-150.
|
[48] |
Rogala J, Zangerl B, Assaad N, et al. In vivo quantification of retinal changes associated with drusen in age-related macular degeneration. Invest Ophthalmol Vis Sci, 2015, 56(3): 1689-1700. DOI: 10.1167/iovs.14-16221.
|
[49] |
Ahlers C, Götzinger E, Pircher M, et al. Imaging of the retinal pigment epithelium in age-related macular degeneration using polarization-sensitive optical coherence tomography. Invest Ophthalmol Vis Sci, 2010, 51(4): 2149-2157. DOI: 10.1167/iovs.09-3817.
|
[50] |
Ying GD, Hung LF, Kee CS, et al. Normal ocular development in young rhesus monkeys (Macaca mulatta). Vision Res, 2007,47(11): 1424-1444. DOI: 10.1016/j.visres.2007.01. 025.
|
[51] |
Mutti DO, Zadnik K, Fusaro RE, et al. Optical and structural development of the crystalline lens in childhood. Invest Ophthalmol Vis Sci, 1998, 39(1): 120-133.
|
[52] |
Torczynski E. Survey of changes in the eye[M]. Aging in nonhuman primates, New York: Van Nostrand Reinhold, 1979:143-157.
|
[53] |
Boothe RG, Williams RA, Kiorpes L, et al. Development of contrast sensitivity in infant Macaca nemestrina monkeys.Science, 1980, 208(4449): 1290-1292.
|
[54] |
Bito LZ, DeRousseau CJ, Kaufman PL, et al. Age-dependent loss of accommodative amplitude in rhesus monkeys: an animal model for presbyopia. Invest Ophthalmol Vis Sci, 1982, 23(1):23-31.
|
[55] |
Bito LZ, Merritt SQ, DeRousseau CJ. Intraocular pressure of rhesus monkey (Macaca mulatta). I. An initial survey of two freebreeding colonies. Invest Ophthalmol Vis Sci, 1979, 18(8): 785-793.
|
[56] |
Razeghinejad MR, Tania TTY, Fudemberg SJ, et al. Pregnancy and glaucoma. Surv Ophthalmol, 2011, 56(4): 324-335. DOI: 10.1016/j.survophthal.2010.11.008.
|
[57] |
Yu W, Cao G, Qiu J, et al. Evaluation of monkey intraocular pressure by rebound tonometer. Mol Vis, 2009, 15: 2196-2201.
|
[58] |
Downs JC, Burgoyne CF, Seigfreid WP, et al. 24-hour IOP telemetry in the nonhuman primate: implant system performance and initial characterization of IOP at multiple timescales. Invest Ophthalmol Vis Sci, 2011, 52(10): 7365-7375. DOI: 10.1167/iovs.11-7955.
|
[59] |
Mansouri K, Shaarawy T. Continuous intraocular pressure monitoring with a wireless ocular telemetry sensor: initial clinical experience in patients with open angle glaucoma. Br J Ophthalmol,2011, 95(5): 627-629. DOI: 10.1136/bjo.2010.192922.
|
[60] |
Realini T, Weinreb RN, Weinreb N, et al. Short-term repeatability of diurnal intraocular pressure patterns in glaucomatous individuals. Ophthalmology, 2011, 118(1): 47-51.
|
|
DOI: 10.1016/j.ophtha.2010.04.027.
|
[61] |
Liu JH, Kripke DF, Hoffman RE, et al. Nocturnal elevation of intraocular pressure in young adults. Invest Ophthalmol Vis Sci,1998, 39(13): 2707-2712.
|
|
|
|