褪黑素与形觉剥夺性近视的关系

doi:DOI: 10.3760/cma.j.issn.1674-845X.2017.08.011

Abstract
Figure/Table
References (37)
Related Citation (15)

Download: PDF (193 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract

Myopia is one of the most common eye abnormalities worldwide. Form deprivation or lenses can induce experimental myopia. Melatonin, an important neuroendocrine hormone of the eye and a myopicrelated factor, may have an important influence on the development of myopia. This paper elaborates
on the relationship between melatonin and form deprivation myopia by focusing on the distribution and synthetic factors of melatonin in the eye, the relationship between melatonin and eye growth rhythm, and the relationship between melatonin and dopamine.

Key words： melatonin form deprivation myopia dopamine

Received: 04 January 2017

Fund:

This study was funded by Shanghai Scientific Research Project (14411969500)

Corresponding Authors: Xiaomei Qu, Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai 200031, China (Email: quxiaomei2002@126.com)

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	Luoli Zhang
	Xiaomei Qu

Cite this article:

Luoli Zhang,Xiaomei Qu. The Relationship between Melatonin and Form Deprivation Myopia[J]. Chinese Journal of Optometry Ophthalmology and Visual science, 2017, 19(8): 509-512.

URL:

https://www.cjoovs.com/EN/DOI: 10.3760/cma.j.issn.1674-845X.2017.08.011 OR https://www.cjoovs.com/EN/Y2017/V19/I8/509

[1]	Alarma-Estrany P, Pintor J. Melatonin receptors in the eye:Location, second messengers and role in ocular physiology.Pharmacol Ther, 2007, 113(3): 507-522. DOI: 10.1016/j.
	pharmthera.2006.11.003.
[2]	Masson-Pevet M, Gauer F, Schuster C, et al. Photic regulation of mt(1) melatonin receptors and 2-iodomelatonin binding in the rat and Siberian hamster. Biol Signals Recept, 2000, 9(3-4): 188-196. DOI: 10.1159/000014638.
[3]	Falcon J, Bolliet V, Collin JP. Partial characterization of serotonin N-acetyltransferases from northern pike (Esox lucius, L) pineal organ and retina: Effects of temperature. Pflugers Arch, 1996,432(3): 386-393.
[4]	Valenciano AI, Alonso-Gómez AL, De Pedro N, et al. Serotonin N-acetyltransferase activity as a target for temperature in the regulation of melatonin production by frog retina. Pflugers Arch,1994, 429(2): 153-159.
[5]	王保贞, 陈悦. 褪黑素及iNOS在豚鼠形觉剥夺性近视眼的表达及作用. 中国实用医刊, 2010, 37(7): 29-31. DOI: 10.3760/cma.j.issn.1674-4756.2010.07.014.
[6]	尹靓瑶, 陈悦, 衡欣. 外源性褪黑素对豚鼠形觉剥夺性近视褪黑素受体、iNOS、C-fos表达的影响. 眼科新进展, 2011, 31(5):407-410.
[7]	Schaeffel F, Bartmann M, Hagel G, et al. Studies on the role of the retinal dopamine/melatonin system in experimental refractive errors in chickens. Vision Res, 1995, 35(9): 1247-1264.
[8]	Hoffmann M, Schaeffel F. Melatonin and deprivation myopia in chickens. Neurochem Int, 1996, 28(1): 95-107.
[9]	Nickla DL, Wildsoet CF, Troilo D. Endogenous rhythms in axial length and choroidal thickness in chicks: Implications for ocular growth regulation. Invest Ophthalmol Vis Sci, 2001, 42(3): 584-588.
[10]	Nickla DL, Rada JA, Wallman J. Isolated chick sclera shows a circadian rhythm in proteoglycan synthesis perhaps associated with the rhythm in ocular elongation. J Comp Physiol A, 1999,185(1): 81-90.
[11]	Nickla DL, Wildsoet C, Wallman J. Visual influences on diurnal rhythms in ocular length and choroidal thickness in chick eyes.Exp Eye Res, 1998, 66(2): 163-181.
[12]	Nickla DL, Wildsoet C, Wallman J. The circadian rhythm in intraocular pressure and its relation to diurnal ocular growth changes in chicks. Exp Eye Res, 1998, 66(2): 183-193.
[13]	Iuvone PM, Tigges M, Stone RA, et al. Effects of apomorphine,a dopamine receptor agonist, on ocular refraction and axial elongation in a primate model of myopia. Invest Ophthalmol Vis Sci, 1991, 32(5): 1674-1677.
[14]	Iuvone PM, Tigges M, Fernandes A, et al. Dopamine synthesis and metabolism in rhesus monkey retina: development, aging,and the effects of monocular visual deprivation. Vis Neurosci,1989, 2(5): 465-471.
[15]	Rada JA, Wiechmann AF. Melatonin receptors in chick ocular
	tissues: Implications for a role of melatonin in ocular growth regulation. Invest Ophthalmol Vis Sci, 2006, 47(1): 25-33. DOI:10.1167/iovs.05-0195.
[16]	Tomlinson A, Phillips CI. Applanation tension and axial length of the eyeball. Br J Ophthalmol, 1970, 54(8): 548.
[17]	陈国府, 周激波, 吕帆. 豚鼠形觉剥夺及恢复过程中眼压变化.眼视光学杂志, 2009, 11(2): 81-84.
[18]	许思思. 豚鼠形觉剥夺性近视视网膜中褪黑素受体的表达及眼压变化的研究. 郑州大学, 2009.
[19]	Pintor J, Pelaez T, Hoyle C, et al. Ocular hypotensive effects of melatonin receptor agonists in the rabbit: further evidence for an MT3 receptor. Br J Pharmacol, 2003, 138(5): 831-836. DOI: 10.1038/sj.bjp.0705118.
[20]	Wiechmann AF, Wirsig-Wiechmann CR. Melatonin receptor mRNA and protein expression in Xenopus laevis nonpigmented ciliary epithelial cells. Exp Eye Res, 2001, 73(5): 617-623. DOI:10.1006/exer. 2001.1073.
[21]	Rohde BH, McLaughlin MA, Chiou LY. Existence and role of endogenous ocular melatonin. J Ocul Pharmacol, 1985, 1(3):235-243.
[22]	Crooke A, Huete-Toral F, Martinez-Aguila A, et al. Melatonin and its analog 5-methoxycarbonylamino-N-acetyltryptamine potentiate adrenergic receptor-mediated ocular hypotensive effects in rabbits: significance for combination therapy in glaucoma. J Pharmacol Exp Ther, 2013, 346(1): 138-145. DOI:10.1124/ jpet.112.202036.
[23]	Samples JR, Krause G, Lewy AJ. Effect of melatonin on intraocular pressure. Curr Eye Res, 1988, 7(7): 649-653.
[24]	Rada JA, Perry CA, Slover M L, et al. Gelatinase A and TIMP-2 expression in the fibrous sclera of myopic and recovering chick eyes. Invest Ophthalmol Vis Sci, 1999, 40(13): 3091-3099.
[25]	Kusakari T, Sato T, Tokoro T. Regional scleral changes in formdeprivation myopia in chicks. Exp Eye Res, 1997, 64(3): 465-476. DOI:10.1006/exer.1996.0242.
[26]	Gottlieb MD, Joshi HB, Nickla DL. Scleral changes in chicks with form-deprivation myopia. Curr Eye Res, 1990, 9(12):1157-1165.
[27]	Wiechmann AF, Rada JA. Melatonin receptor expression in thecornea and sclera. Exp Eye Res, 2003, 77(2): 219-225.
[28]	Stone RA, Pardue MT, Iuvone PM, et al. Pharmacology of myopia and potential role for intrinsic retinal circadian rhythms.Exp Eye Res, 2013, 114: 35-47. DOI: 10.1016/j.exer.2013.01. 001. [29] Pendrak K, Nguyen T, Lin T, et al. Retinal dopamine in therecovery from experimental myopia. Curr Eye Res, 1997, 16(2):152-157.
[30]	董枫, 周翔天, 瞿佳. 多巴胺及相关生物活性物质与实验性近视的关系. 国际眼科纵览, 2007, 31(6): 399-403.
[31]	Stone RA, Lin T, Laties AM, et al. Retinal dopamine and formdeprivation myopia. Proc Natl Acad Sci USA, 1989, 86(2):704-706.
[32]	Nickla DL, Totonelly K. Dopamine antagonists and brief vision distinguish lens-induced- and form-deprivation-induced myopia.Exp Eye Res, 2011, 93(5): 782-785. DOI: 10.1016/j.exer.2011.08.001.
[33]	赵颖熙. 光照强度对豚鼠屈光发育的影响及视网膜多巴胺变化研究. 复旦大学, 2011.
[34]	王丽娟, 瞿小妹. 光照度调节眼屈光发育的研究进展. 中华眼视光学与视觉科学杂志, 2014, 16(1): 61-64. DOI: 10.3760/cma.j.issn.1674-845X.2014.01.015.
[35]	Cahill GM, Grace MS, Besharse JC. Rhythmic regulation of retinal melatonin: metabolic pathways, neurochemical mechanisms, and the ocular circadian clock. Cell Mol Neurobiol, 1991, 11(5):529-560.
[36]	赵桂玲. 褪黑素在视网膜上的合成及生理药理作用. 国外医学(眼科学分册), 2002, 26(2): 88-91. DOI: 10.3760/cma.j.issn.1673-5803.2002.02.007.
[37]	Ohngemach S, Feldkaemper M, Schaeffel F. Pineal control of the dopamine D-2-receptor gene and dopamine release in the retina of the chicken and their possible relation to growth rhythms of the eye. J Pineal Res, 2001, 31(2): 145-154.