MMPs/TIMPs在近视发生发展中的机制研究进展

doi:10.3760/cma.j.issn.1674-845X.2018.01.012

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Abstract

The incidence of myopia has increased in recent years. Studies of myopic animal models and clinical trials have demonstrated that matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) play important roles in the development of myopia. We summarizes the association between MMPs/TIMPs and myopia development. It also clarifies the effect of MMPs/TIMPs on scleral and other ocular tissues from the perspective of gene expression, mRNA levels, and protein concentrations.

Key words： myopia matrix metalloproteinases tissue inhibitors of matrix metalloproteinases

Received: 22 June 2017

Fund:

Shanghai Health and Family Planning Commission Research Project (201440354), and the Science and Technology Commission of Shanghai (17DZ2260100)

Corresponding Authors: Jibo Zhou, Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai 200011, China (Email: zhoujibo1000@aliyun.com)

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https://www.cjoovs.com/EN/10.3760/cma.j.issn.1674-845X.2018.01.012 OR https://www.cjoovs.com/EN/Y2018/V20/I1/61

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