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The Effect of Intraocular Pressure on Myopia Progression in Adolescents |
Yuan Deng,Minna Rong,Wen Deng,Xing Cao,Wen Li,Dan Zhou,Changhua Ye |
Changsha Aier Eye Hospital, Aier School of Ophthalmology, Central South University, Changsha 410015,China Changsha Health Vocation College, Changsha 410100, China |
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Abstract Objective: To investigate the effect of intraocular pressure (IOP) on myopia progression in adolescents.Methods: This was a prospective study of 112 myopia subjects (ages 6-18 years old) in Changsha Aier Hospital from July 2014 to December 2015. Depending on the mean IOP at baseline, the subjects were categorized into three groups: High IOP (IOPH, 21 mmHg < mean IOP < 30 mmHg), moderate IOP (IOPM,15 mmHg < mean IOP ≤ 21 mmHg), and low IOP (IOPL, 10 mmHg < mean IOP ≤ 15 mmHg). Regular follow-ups were at 6, 12, and 18 months after baseline. Twenty-four hour IOP, spherical equivalent (SE),axial length (AL), and central corneal thickness were measured at each follow-up visit. Repeated measures analysis of variance and logistic regression analysis were performed to estimate the factors influencing
SE and AL. Results: At last, 103 cases finish the follow-up. The rates of SE progression for each group were determined for the 18-month follow-up period. For the IOPH group, IOPM group, IOPL group, the SE progression rate was -0.87±0.90 diopter (D)/year, -0.59 ± 0.89 D/year, -0.33 ± 0.32 D/year respectively,the rate of change in SE over the study period was significant (F=5.848, P=0.017). The rates of AL change for each group were also determined. For the IOPH group, IOPM group, IOPL group, the rate was 0.40 ± 0.29 mm/year, 0.18 ± 0.31 mm/year, 0.17 ± 0.30 mm/year respectively , the rate of change in AL over the study period was significant (F=5.265, P=0.007). Eyes with higher mean IOPs were likely to have SE progression (OR=0.454, 95%CI=0.317-0.716, P=0.007). Younger subjects were likely to have greater AL
elongation than older subjects (OR=1.433, 95%CI=0.994-1.506, P=0.015). Conclusions: Adolescents with higher mean IOPs are associated with the SE changes that are consistent with the changes in AL elongation.These findings suggest that IOP plays a major role in myopia progression in adolescents.
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Received: 29 November 2017
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Fund: Science Research Foundation of Aier Eye Hospital Group (AF146D14) |
Corresponding Authors:
Changhua Ye, Changsha Aier Eye Hospital, Aier School of Ophthalmology, Central South University, Changsha 410015, China (Email: changhuaye@csu.edu.cn)
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[1] |
Wu PC, Huang HM, Yu HJ, et al. Epidemiology of myopia. Asia Pac J Ophthalmol (Phila), 2016, 5(6): 386-393. DOI: 10.1097/
|
|
APO.0000000000000236.
|
|
APO.0000000000000236.
|
[2] |
Pararajasegaram R. Vision 2020-the right to sight: from strategies to action. Am J Ophthalmol, 1999, 128(3): 359-360.
|
[2] |
Pararajasegaram R. Vision 2020-the right to sight: from strategies to action. Am J Ophthalmol, 1999, 128(3): 359-360.
|
[3] |
李玲. 国民视觉健康报告. 北京: 北京大学出版社, 2016: 48-54.
|
[3] |
李玲. 国民视觉健康报告. 北京: 北京大学出版社, 2016: 48-54.
|
[4] |
Mitchell P, Hourihan F, Sandbach J, et al. The relationship between glaucoma and myopia: the Blue Mountains Eye Study.
|
[4] |
Mitchell P, Hourihan F, Sandbach J, et al. The relationship between glaucoma and myopia: the Blue Mountains Eye Study.
|
|
Ophthalmology, 1999, 106(10): 2010-2015.
|
|
Ophthalmology, 1999, 106(10): 2010-2015.
|
[5] |
McMonnies CW. Intraocular pressure spikes in keratectasia,axial myopia, and glaucoma. Optom Vis Sci, 2008, 85(10):
|
10 |
18-1026. DOI: 10.1097/OPX.0b013e3181890e91.
|
[5] |
McMonnies CW. Intraocular pressure spikes in keratectasia,axial myopia, and glaucoma. Optom Vis Sci, 2008, 85(10):
|
10 |
18-1026. DOI: 10.1097/OPX.0b013e3181890e91.
|
[6] |
Phillips JR, McBrien NA. Pressure-induced changes in axial eye length of chick and tree shrew: significance of myofibroblasts in the sclera. Invest Ophthalmol Vis Sci, 2004, 45(3): 758-763.
|
[7] |
北京医学会眼科学分会. 关于24 小时眼压监测规范的探讨.中华眼科杂志, 2014, 5(50): 384-385. DOI: 10.3760/cma.j.issn.
|
[6] |
Phillips JR, McBrien NA. Pressure-induced changes in axial eye length of chick and tree shrew: significance of myofibroblasts in the sclera. Invest Ophthalmol Vis Sci, 2004, 45(3): 758-763.
|
[7] |
北京医学会眼科学分会. 关于24 小时眼压监测规范的探讨.中华眼科杂志, 2014, 5(50): 384-385. DOI: 10.3760/cma.j.issn.
|
04 |
12-4081.2014.05.023.
|
[8] |
杨铮, 雷方, 周瑞雅, 等. 眼压在儿童不同程度近视和眼轴变化中的作用. 中华实验眼科杂志, 2016, 34(7): 635-638. DOI:
|
04 |
12-4081.2014.05.023.
|
[8] |
杨铮, 雷方, 周瑞雅, 等. 眼压在儿童不同程度近视和眼轴变化中的作用. 中华实验眼科杂志, 2016, 34(7): 635-638. DOI:
|
10 |
3760/cma.j.issn.2095-0160.2016.07.013.
|
10 |
3760/cma.j.issn.2095-0160.2016.07.013.
|
[9] |
Li SM, Li SY, Kang MT, et al. Near Work Related Parameters and Myopia in Chinese Children: the Anyang Childhood Eye
|
|
Study. PLoS One, 2015, 10(8): e0134514. DOI: 10.1371/journal.pone.0134514.
|
[10] |
胡平会, 郭晓枚. 不同程度的屈光矫正对青少年儿童近视进展的影响. 国际眼科杂志, 2012, 12(11): 2233-2234.DOI:
|
[9] |
Li SM, Li SY, Kang MT, et al. Near Work Related Parameters and Myopia in Chinese Children: the Anyang Childhood Eye
|
|
Study. PLoS One, 2015, 10(8): e0134514. DOI: 10.1371/journal.pone.0134514.
|
[10] |
胡平会, 郭晓枚. 不同程度的屈光矫正对青少年儿童近视进展的影响. 国际眼科杂志, 2012, 12(11): 2233-2234.DOI:
|
10 |
3969/j.issn.1672-5123.2012.11.65.
|
10 |
3969/j.issn.1672-5123.2012.11.65.
|
[11] |
杨晓桦, 王颖. 屈光不正儿童阿托品散瞳前后眼压值的观察.中国中医眼科杂志, 2014, 24(5): 350-353.
|
[12] |
周云, 冯敏, 何娟. 儿童阿托品散瞳前后眼压的临床研究. 临床眼科杂志, 2013, 21(3): 258-259. DOI: 10.3969/j.issn.1006-8422.
|
[11] |
杨晓桦, 王颖. 屈光不正儿童阿托品散瞳前后眼压值的观察.中国中医眼科杂志, 2014, 24(5): 350-353.
|
[12] |
周云, 冯敏, 何娟. 儿童阿托品散瞳前后眼压的临床研究. 临床眼科杂志, 2013, 21(3): 258-259. DOI: 10.3969/j.issn.1006-8422.
|
20 |
13.03.026.
|
[13] |
俞萍萍, 孙朝晖. 近视与眼动参数变化的研究进展. 国际眼科纵览, 2008, 32(3): 160-163. DOI: 10.3760/cma.j.issn.1673-
|
20 |
13.03.026.
|
[13] |
俞萍萍, 孙朝晖. 近视与眼动参数变化的研究进展. 国际眼科纵览, 2008, 32(3): 160-163. DOI: 10.3760/cma.j.issn.1673-
|
58 |
03.2008.03.005.
|
58 |
03.2008.03.005.
|
[14] |
Jensen H. Myopia progression in young school children and intraocular pressure. Doc Ophthalmol, 1992, 82(3): 249-255.
|
[14] |
Jensen H. Myopia progression in young school children and intraocular pressure. Doc Ophthalmol, 1992, 82(3): 249-255.
|
[15] |
Mohan M, Rao VA, Dada VK. Experimental myopia in the rabbit. Exp Eye Res, 1977, 25(1): 33-38.
|
[15] |
Mohan M, Rao VA, Dada VK. Experimental myopia in the rabbit. Exp Eye Res, 1977, 25(1): 33-38.
|
[16] |
De Rousseau CJ, Bito LZ. Intraocular pressure of rhesus monkeys (Macaca mulatta) II. Juvenile ocular hypertension and
|
[16] |
De Rousseau CJ, Bito LZ. Intraocular pressure of rhesus monkeys (Macaca mulatta) II. Juvenile ocular hypertension and
|
|
its apparent relationship to ocular growth. Exp Eye Res, 1981,32(4): 407-417.
|
[17] |
Papastergiou GI, Schmid GF, Riva CE, et al. Ocular axial length and choroidal thickness in newly hatched chicks and one-year-old chickens fluctuate in a diurnal pattern that is influenced by visual experience and intraocular pressure changes. Exp Eye Res,1998, 66(2): 195-205. DOI: 10.1006/exer.1997.0421.
|
|
its apparent relationship to ocular growth. Exp Eye Res, 1981,32(4): 407-417.
|
[18] |
Read SA, Collins MJ, Annis-Brown T, et al. The short-term influence of elevated intraocular pressure on axial length.
|
[17] |
Papastergiou GI, Schmid GF, Riva CE, et al. Ocular axial length and choroidal thickness in newly hatched chicks and one-year-old chickens fluctuate in a diurnal pattern that is influenced by visual experience and intraocular pressure changes. Exp Eye Res,1998, 66(2): 195-205. DOI: 10.1006/exer.1997.0421.
|
|
Ophthalmic Physiol Opt, 2011, 31(4): 398-403. DOI: 10.1111/j.1475-1313.2011.00845.x.
|
[19] |
Weinreb RN, Liu JH. Nocturnal rhythms of intraocular pressure.Arch Ophthalmol, 2006, 124(2): 269-270. DOI: 10.1001/
|
[18] |
Read SA, Collins MJ, Annis-Brown T, et al. The short-term influence of elevated intraocular pressure on axial length.
|
|
archopht.124.2.269.
|
|
Ophthalmic Physiol Opt, 2011, 31(4): 398-403. DOI: 10.1111/j.1475-1313.2011.00845.x.
|
[19] |
Weinreb RN, Liu JH. Nocturnal rhythms of intraocular pressure.Arch Ophthalmol, 2006, 124(2): 269-270. DOI: 10.1001/
|
|
archopht.124.2.269.
|
|
|
|