|
|
Comparative Study of Dry Eye after FS-LASIK and Off-Flap LASEK |
Qidi Hu, Lingli Xu, Rong Ma, Zhe Zhang, Wei Mao, Yusheng Zhou, Qinbo Li |
Refractive Surgery Center, the Ningbo Eye Hospital, Ningbo 315040, China |
|
|
Abstract To compare dry eye characteristics in eyes after femtosecond laser-assisted in situ keratomileusis (FS-LASIK) or off-flap laser epithelial keratomileusis (LASEK). Methods: Thirty eyes of 30 patients with myopia who had FS-LASIK (FS-LASIK group) and 30 eyes of 30 patients with myopia who had off-flap LASEK (LASEK group) at the Refractive Surgery Center of the Ningbo Eye Hospital from August 2016 to February 2017 were prospectively enrolled in this clinical study. The Ocular Surface Disease Index (OSDI) questionnaire, Schirmer Ⅰ test (SⅠT), tear breakup time (BUT), and corneal fluorescein staining were evaluated preoperatively and 3, 6, and 12 months postoperatively. Data from the two groups were analyzed with a two-way repeated measures ANOVA. Results: There were no statistically significant differences between the two groups for the OSDI questionnaire score, SⅠT, and corneal fluorescein staining at all time-points and for the preoperative and 3 and 6 months postoperative BUT(P>0.05). The BUT of the FS-LASIK group was higher than that for the LASEK group after 12 months (t=2.81, P=0.01). Compared with the preoperative evaluation, corneal staining increased in the FS-LASIK group after 3 months (t=3.48, P=0.008), but there were no statistically significant differences between 6 and 12 months postoperative and the preoperative. There were no statistically significant differences between postoperative and preoperative for the corneal fluorescein staining in the LASEK group (P>0.05). There were no statistically significant differences between postoperative and preoperative for the OSDI questionnaire score and Schirmer Ⅰ in both groups (P>0.05), and there were no statistically significant differences between 3 and 6 months postoperative and the preoperative for the BUT in both groups (P>0.05). Compared with the preoperative evaluation, the BUT increased in the FS-LASIK and LASEK groups after 12 months (t=3.14, P=0.01; t=2.43, P=0.04). Conclusions: Dry eye is slight after FS-LASIK and off-flap LASEK surgeries, and both techniques have a similar effect on dry eye.
|
Received: 29 December 2018
|
Fund: Ningbo Natural Science Foundation (2017A610241, 2018A610422); Zhejiang Public Welfare Technology Application Research (LGF19H090006) |
Corresponding Authors:
Qidi Hu, Refractive Surgery Center, the Ningbo Eye Hospital, Ningbo 315040, China
(Email: huqidi2007@163.com)
|
|
|
|
[1] |
Kuryan J, Cheema A, Chuck RS. Laser-assisted subepithelial keratectomy (LASEK) versus laser-assisted in-situ keratomileusis (LASIK) for correcting myopia. Cochrane Database Syst Rev, 2017, 2: CD011080. DOI: 10.1002/14651858.CD011080.
|
[2] |
Raoof D, Pineda R. Dry eye after laser in-situ keratomileusis. Semin Ophthalmol, 2014, 29(5-6): 358-362. DOI: 10.3109/ 08820538.2014.962663.
|
[3] |
Lee JB, Ryu CH, Kim JH, et al. Comparison of tear secretion and tear film instability after photorefractive keratectomy and laser in situ keratomileusis. J Cataract Refract Surg, 2000, 26(9):1326-1331. DOI: 10.1016/S0886-3350(00)00566-6.
|
[4] |
Barequet IS, Hirsh A, Levinger S. Effect of thin femtosecond LASIK flaps on corneal sensitivity and tear function. J Refract Surg, 2008, 24(9): 897-902. DOI: 10.1055/s-0028-1090620.
|
[5] |
Pajic B, Vastardis I, Pajic-Eggspuehler B, et al. Femtosecond laser versus mechanical microkeratome-assisted flap creation for LASIK: A prospective, randomized, paired-eyestudy. Clin Ophthalmol, 2014, 8: 1883-1889. DOI: 10.2147/OPTH.S68124.
|
[6] |
Bron AJ, Evans VE, Smith JA. Grading of corneal and conjunctival staining in the context of other dry eye tests. Cornea, 2003, 22(7): 640-650. DOI: 10.1097/00003226-200310000- 00008. [7] Dooley I, D'Arcy F, O'Keefe M. Comparison of dry-eye disease severity after laser in situ keratomileusis and laser-assisted subepithelial keratectomy. J Cataract Refract Surg, 2012, 38(6): 1058-1064. DOI: 10.1016/j.jcrs.2012.01.028.
|
[8] |
Konomi K, Chen L-L, Tarko RS, et al. Preoperative characteristics and a potential mechanism of chronic dry eye after LASIK. Invest Ophthalmol Vis Sci, 2008, 49(1): 168-174. DOI: 10.1167/ iovs.07-0337.
|
[9] |
宋建军, 张慧丽. 不同角膜屈光手术治疗近视及散光患者术 后视觉质量和干眼及生物力学稳定性研究. 国际眼科杂志, 2017, 17(10): 1837-1840. DOI: 10.3980/j.issn.1672-5123.2017.
|
10 |
08.
|
[10] |
Armstrong RA. Statistical guidelines for the analysis of data obtained from one or both eyes. Ophthalmic Physiol Opt, 2013, 33(1): 7-14. DOI: 10.1111/opo.12009.
|
[11] |
牛广增, 范玉香, 高瑞新, 等. LASIK和LASEK术后角膜神 经损伤恢复情况比较. 中华眼视光学与视觉科学杂志, 2014, 16(8): 487-492. DOI: 10.3760/cma.j.issn.1674-845X.2014.08.
|
|
010.
|
[12] |
Salomao MQ, Ambrósio R Jr, Wilson SE. Dry eye associated with laser in situ keratomileusis: Mechanical microkeratome versus femtosecond laser. J Cataract Refract Surg, 2009, 35(10): 1756-1760. DOI: 10.1016/j.jcrs.2009.05.032.
|
[13] |
Baudouin C, Aragona P, Messmer EM, et al. Role of hyperosmolarity in the pathogenesis and management of dry eye disease: proceedings of the OCEAN group meeting. Ocul Surf, 2013, 11(4): 246-258. DOI: 10.1016/j.jtos.2013.07.003.
|
[14] |
Pinto-Fraga J, López-Miguel A, González-García MJ, et al. Topical fluorometholone protects the ocular surface of dry eye patients from desiccating stress: a randomized controlled clinical trial. Ophthalmology, 2016, 123(1): 141-153. DOI: 10.1016/ j.ophtha.2015.09.029.
|
|
|
|