Objective To explore the difference and agreement in the measurement of central anterior chamber depth（CACD） and peripheral anterior chamber depth（PACD） in the acute primary angle-closure glaucoma（APACG） between Sirius triaxial anterior system and ultrasound biomicroscopy（UBM）. Methods Prospective control study. Forty eyes of 40 APACG patients were selected，respectively， using Sirius triaxial anterior system and UBM measuring CACD and PACD. Paired samples t-test and Pearson linear correlation for statistical analysis， and application of Bland-Altman analysis to evaluate the two methods of measurement consistency. Results The CACD values measured by Sirius triaxial anterior system and UBM were （1.87±0.30）mm and （1.98±0.30）mm，PACD values were （0.61±0.21）mm and （0.56±0.21）mm， respectively， indicating a significant difference （t=-6.533， 2.432， P＜0.05）； and a significant linear correlation between them （r=0.944， 0.796， P＜0.05）. Sirius triaxial anterior system and UBM measurement of CACD value， and PACD value difference were -0.10±0.10 mm， 0.05±0.14 mm respectively， 95% limits of agreement were （-0.30， 0.09）mm和（-0.22， 0.32）mm. Conclusion Sirius anterior system and UBM show good agreement in the measurement of ACD in patients with APACG， the two instruments can be replaced.