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Research Progress on Tear Film and the Ocular Surface Environment |
Dan Yan, Chenxi Yan, Yao Fu |
Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China |
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Abstract The tear film covering the entire ocular surface is an important component of the ocular surface microenvironment. The disturbance of the homeostasis of the tear film can result in the dysfunction of other ocular structures, which will exacerbate the development of ocular diseases. This article reviews recent research progress on the effect of tear film on other components of the ocular surface, such as the ocular epithelium, corneal stroma, corneal nerve and ocular microbiota to provide new ideas for the pathogenesis and treatment of ocular surface diseases.
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Received: 11 March 2019
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Fund: National Natural Science Foundation of China (81800873, 81770888, 81570812); Shanghai Pujiang Program (18PJD025) |
Corresponding Authors:
Yao Fu, Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China (Email: fuyaofy@sina.com)
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[1] |
Craig JP, Nichols KK, Akpek EK, et al. TFOS DEWS II Definition and Classification Report. Ocul Surf, 2017, 15(3):276-283. DOI: 10.1016/j.jtos.2017.05.008.
|
[2] |
Zhang X, M VJ, Qu Y, et al. Dry eye management: Targeting the ocular surface microenvironment. Int J Mol Sci, 2017, 18(7): 1398-1413. DOI: 10.3390/ijms18071398.
|
[3] |
Willcox M, Argüeso P, Georgiev GA, et al. TFOS DEWS II Tear Film Report. Ocul Surf, 2017, 15(3): 366-403. DOI: 10.1016/j. jtos.2017.03.006.
|
[4] |
Nencheva Y, Ramasubramanian A, Eftimov P, et al. Effects of lipid saturation on the surface properties of human meibum Films. Int J Mol Sci, 2018, 19(8): 2209-2216. DOI: 10.3390/ijms 19082209.
|
[5] |
Rantamäki AH, Holopainen JM. The effect of phospholipids on tear film lipid layer surface activity. Invest Ophthalmol Vis Sci, 2017, 58(1): 149-154. DOI: 10.1167/iovs.16-20468.
|
[6] |
Ivanova S, Tonchev V, Yokoi N, et al. Surface properties of squalene/meibum films and NMR confirmation of squalene in tears. Int J Mol Sci, 2015, 16(9): 21813-21831. DOI: 10.3390/ ijms160921813.
|
[7] |
刘祖国, 林志荣. 重视干眼中眼表炎症的作用. 中华眼视光学与视觉科学杂志, 2012, 14(4): 193-196. DOI: 10.3760/cma.j. issn.1674-845X.2012.04.001.
|
[8] |
Hodges RR, Dartt DA. Tear film mucins: Front line defenders of the ocular surface; comparison with airway and gastrointestinal tract mucins. Exp Eye Res, 2013, 117(3): 62-78. DOI: 10.1016/j. exer.2013.07.027.
|
[9] |
Ablamowicz AF, Nichols JJ. Ocular surface membrane-associated mucins. Ocul Surf, 2016, 14(3): 331-341. DOI: 10. 1016/j.jtos.2016.03.003.
|
[10] |
Rusciano D, Pezzino S, Olivieri M, et al. Age-related dry eye lactoferrin and lactobionic acid. Ophthalmic Res, 2018, 60(2): 94-99. DOI: 10.1159/000489093.
|
[11] |
Karnati R, Laurie DE, Laurie GW. Lacritin and the tear proteome as natural replacement therapy for dry eye. Exp Eye Res, 2013, 117(1): 39-52. DOI: 10.1016/j.exer.2013.05.020.
|
[12] |
Schicht M, Garreis F, Hartjen N, et al. SFTA3-a novel surfactant protein of the ocular surface and its role in corneal wound healing and tear film surface tension. Sci Rep, 2018, 8(1): 9791. DOI: 10.1038/s41598-018-28005-9.
|
[13] |
Jalbert I. Diet, nutraceuticals and the tear film. Exp Eye Res, 2013, 117(9): 138-146. DOI: 10.1016/j.exer.2013.08.016.
|
[14] |
Sweeney DF, Millar TJ, Raju SR. Tear film stability: A review. Exp Eye Res, 2013, 117(8): 28-38. DOI: 10.1016/j.exer.2013.08. 010.
|
[15] |
Wakamatsu TH, Sato EA, Matsumoto Y, et al. Conjunctival in vivo confocal scanning laser microscopy in patients with Sjögren syndrome. Invest Ophthalmol Vis Sci, 2010, 51(1): 144- 150. DOI: 10.1167/iovs.08-2722.
|
[16] |
Hampel U, Garreis F, Burgemeister F, et al. Effect of intermittent shear stress on corneal epithelial cells using an in vitro flow culture model. Ocul Surf, 2018, 16(3): 341-351. DOI: 10.1016/j. jtos.2018.04.005.
|
[17] |
Labbé A, Liang Q, Wang Z, et al. Corneal nerve structure and function in patients with non-sjogren dry eye: Clinical correlations. Invest Ophthalmol Vis Sci, 2013, 54(8): 5144-5150. DOI: 10.1167/iovs.13-12370.
|
[18] |
Dua HS, Said DG, Messmer EM, et al. Neurotrophic keratopathy. Prog Retin Eye Res, 2018, 66(4): 107-131. DOI: 10. 1016/j.preteyeres.2018.04.003.
|
[19] |
Zhang M, Chen J, Luo L, et al. Altered corneal nerves in aqueous tear deficiency viewed by in vivo confocal microscopy. Cornea, 2005, 24(7): 818-824. DOI: 10.1097/01.ico.0000154402.01710. 95.
|
[20] |
Lambiase A, Micera A, Sacchetti M, et al. Alterations of tear neuromediators in dry eye disease. Arch Ophthalmol, 2011, 129(8): 981-986. DOI: 10.1001/archophthalmol.2011.200.
|
[21] |
Belmonte C, Brock JA, Viana F. Converting cold into pain. Exp Brain Res, 2009, 196(1): 13-30. DOI: 10.1007/s00221-009-1797- 2.
|
[22] |
Belmonte C, Nichols JJ, Cox SM, et al. TFOS DEWS II pain and sensation report. Ocul Surf, 2017, 15(3): 404-437. DOI: 10. 1016/j.jtos.2017.05.002.
|
[23] |
刘凡菲, 李炜, 刘祖国, 等. 角膜上皮屏障功能的研究现状. 中华眼科杂志, 2016, 52(8): 631-635. DOI: 10.3760/cma.j.issn. 0412-4081.2016.08.019.
|
[24] |
Efron N. Contact lens-induced changes in the anterior eye as observed in vivo with the confocal microscope. Prog Retin Eye Res, 2007, 26(4): 398-436. DOI: 10.1016/j.preteyeres.2007.03. 003.
|
[25] |
Tuominen IS, Konttinen YT, Vesaluoma MH, et al. Corneal innervation and morphology in primary Sjögren's syndrome. Invest Ophthalmol Vis Sci, 2003, 44(6): 2545-2549. DOI: 10. 1167/iovs.02-1260.
|
[26] |
李月明, 张红. 睑板腺功能障碍的病因. 国际眼科纵览, 2018, 42(6): 376-380. DOI: 10.3760/cma.j.issn.1673-5803.2018.06. 004.
|
[27] |
Villani E, Beretta S, De Capitani M, et al. In vivo confocal microscopy of meibomian glands in Sjögren's syndrome. Invest Ophthalmol Vis Sci, 2011, 52(2): 933-939. DOI: 10.1167/iovs. 10-5995.
|
[28] |
Alhatem A, Cavalcanti B, Hamrah P. In vivo confocal microscopy in dry eye disease and related conditions. Semin Ophthalmol, 2012, 27(5-6): 138-148. DOI: 10.3109/08820538. 2012.711416.
|
[29] |
Lin H, Li W, Dong N, et al. Changes in corneal epithelial layer inflammatory cells in aqueous tear-deficient dry eye. Invest Ophthalmol Vis Sci, 2010, 51(1): 122-128. DOI: 10.1167/iovs. 09-3629.
|
[30] |
St Leger AJ, Caspi RR. Visions of Eye Commensals: The known and the unknown about how the microbiome affects eye disease. Bioessays, 2018, 40(11): e1800046. DOI: 10.1002/bies. 201800046.
|
[31] |
褚晨晨, 茹玉莎, 张琰, 等. 干眼新型干预手段的研究进展及其对眼表微环境的保护作用机制. 国际眼科纵览, 2017, 41(6): 400-405. DOI: 10.3760/cma.j.issn.1673-5803.2017.06.009.
|
[32] |
Shin H, Price K, Albert L, et al. Changes in the eye microbiota associated with contact lens wearing. MBio, 2016, 7(2): e00198. DOI: 10.1128/mBio.00198-16.
|
|
|
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