葡萄膜炎内毒素耐受机制的研究现状

doi:10.3760/cma.j.cn115909-20191117-00309

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Abstract Endotoxin tolerance, refers to a series of complex and adaptive adjustment reaction produced by the body given small dose of lipopolysaccharide (LPS) in advance. It is a phenomenon of decreased responsiveness of the body or cells to subsequent stimulation. The pretreatment not only can prevent the LPS from causing excessive inflammation in the body, but also can relieve the symptoms of endotoxin-induced uveitis. Therefore, if we can clarify the mechanism and key control factor of endotoxin tolerance in uveitis, we may find new targets for the treatment in uveitis, which is based on endotoxin tolerance.

Key words： endotoxin-induced uveitis endotoxin tolerance mechanism of tolerance study status

Received: 17 November 2019

Fund:National Natural Science Foundation of China (81471575); Natural Science Foundation of Gansu Province (17JR5RA225)

Corresponding Authors: Hong Lu, Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China; Department of Ophthalmology, the First Hospital of Lanzhou University, Lanzhou 730000, China (Email: honglucmu@outlook.com)

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