OCTA对青少年近视人群视网膜微血管密度的观察

doi:10.3760/cma.j.cn115909-20200121-00018

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Abstract Objective: To investigate the correlation between myopia and superficial retinal vascular density (SRVD) and retinal thickness in adolescent myopia using optical coherence tomography angiography (OCTA). Methods: This study was a prospective cross-sectional study. A total of 105 myopia patients (193 eyes) aged 7-14 years who visited the Department of Ophthalmology, West China Hospital, Sichuan University, from May 2018 to November 2018 were included. All patients were examined by optical coherence tomography (OCT) and OCTA. Patients were divided into three groups based on the degree of myopia:mild, moderate and severe. One-way analysis of variance was performed on the macular foveal retinal thickness and SRVD at various sites. Pearson correlation was performed between the retinal thickness and superficial retinal vessel density by Pearson correlation analysis. Spearman correlation was performed between the spherical equivalent (SE) and the SRVD and between the macular foveal retinal thickness and the SRVD at various sites. Results: The differences in the parafovea, outer ring and the entire 6 mm diameter of the SRVD in the mild, moderate and high myopia groups were statistically significant (F=11.651, 14.499, 14.232, P<0.001). There was a weak positive correlation between age and macular foveal retinal thickness (r=0.187, P=0.011), but there was no correlation between age and SRVD at any site. The SE was correlated with the parafoveal SRVD (r=-0.301, P<0.001), the curve was correlated with the SRVD outer ring and the entire SRVD area (r=-0.319, P<0.001; r=-0.307, P<0.001). However, there was no significant correlation between the SE and the foveal SRVD and macular foveal retinal thickness. The macular foveal retinal thickness was correlated with the foveal SRVD (r=0.691, P<0.001), but no correlation with parafoveal, outer ring and entire SRVD. Conclusions: The degree of myopia in adolescents is negatively correlated with the parafovea, outer ring and the entire SRVD. The macular foveal retinal thickness is positively correlated with age and the foveal SRVD.

Key words： adolescent myopia superficial retinal vessel density macular fovea retinal thickness

Received: 21 January 2020

Corresponding Authors: Longqian Liu, Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, China (Email: b.q15651@hotmail.com)

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https://www.cjoovs.com/EN/10.3760/cma.j.cn115909-20200121-00018 OR https://www.cjoovs.com/EN/Y2020/V22/I5/354

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