黏着斑激酶与眼科相关疾病的研究进展

doi:10.3760/cma.j.cn115909-20190310-00067

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Abstract Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase, widely distributed in the cytoplasm of cells in the body. It can transmit signals from cell membrane receptors and intercellular growth factors, and participate in the regulation of cell growth and differentiation, adhesion and migration, proliferation and apoptosis, and other important biological processes. FAK is at the intersection of many signal transduction pathways in cells, and researchers have confirmed that it plays an important role in many systemic diseases. This review summarizes the general characteristics of FAK and its functions in ophthalmic diseases.

Key words： focal adhesion kinase ocular embryogenesis cataract glaucoma vitreoretinal diseases corneal diseases

Received: 10 March 2019

Fund:National Natural Science Foundation of China (81670859)

Corresponding Authors: Xuanchu Duan, Department of Ophthalmology, The Second Xiangya Hospital of Central South University, Changsha 410011, China; Hunan Clinical Research Center for Ocular Surface Diseases, Changsha Aier Eye Hospital, Changsha 410015, China (Email: duanxchu@csu.edu.cn)

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https://www.cjoovs.com/EN/10.3760/cma.j.cn115909-20190310-00067 OR https://www.cjoovs.com/EN/Y2020/V22/I5/397

[1]	Schaller MD, Borgman CA, Cobb BS, et al. pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc Natl Acad Sci USA, 1992, 89(11): 5192- 5196. DOI: 10.1073/pnas.89.11.5192.
[2]	Lee BY, Timpson P, Horvath LG, et al. FAK signaling in human cancer as a target for therapeutics. Pharmacol Ther, 2015, 146:132-149. DOI: 10.1016/j.pharmthera.2014.10.001.
[3]	Serrels A, Lund T, Serrels B, et al. Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity. Cell, 2015, 163(1): 160-173. DOI: 10.1016/j.cell. 2015.09.001.
[4]	Kadaré G, Gervasi N, Brami-Cherrier K, et al. Conformational dynamics of the focal adhesion targeting domain control specific functions of focal adhesion kinase in cells. J Biol Chem, 2015, 290(1): 478-491. DOI: 10.1074/jbc.M114.593632.
[5]	Zak TJ, Koshman YE, Samarel AM, et al. Regulation of focal adhesion kinase through a direct interaction with an endogenous inhibitor. Biochemistry, 2017, 56(35): 4722-4731. DOI: 10.1021/acs.biochem.7b00616.
[6]	Sulzmaier FJ, Jean C, Schlaepfer DD. FAK in cancer: Mechanistic findings and clinical applications. Nat Rev Cancer, 2014, 14(9): 598-610. DOI: 10.1038/nrc3792.
[7]	Golubovskaya VM. FAK and Nanog cross talk with p53 in cancer stem cells. Anticancer Agents Med Chem, 2013, 13(4): 576-580. DOI: 10.2174/1871520611313040006.
[8]	Chung DJ, Wang CJ, Yeh CW, et al. Inhibition of the proliferation and invasion of C6 glioma cells by tricin via the upregulation of focal-adhesion-kinase-targeting MicroRNA-7. J Agric Food Chem, 2018, 66(26): 6708-6716. DOI: 10.1021/acs. jafc.8b00604.
[9]	Chen JS, Li HS, Huang JQ, et al. MicroRNA-379-5p inhibits tumor invasion and metastasis by targeting FAK/AKT signaling in hepatocellular carcinoma. Cancer Lett, 2016, 375(1): 73-83. DOI: 10.1016/j.canlet.2016.02.043.
[10]	Nguyen N, Yi JS, Park H, et al. Mitsugumin 53 (MG53) ligase ubiquitinates focal adhesion kinase during skeletal myogenesis. J Biol Chem, 2014, 289(6): 3209-3216. DOI: 10.1074/jbc.M113. 525154.
[11]	Brami-Cherrier K, Gervasi N, Arsenieva D, et al. FAK dimerization controls its kinase-dependent functions at focal adhesions. EMBO J, 2014, 33(4): 356-370. DOI: 10.1002/embj. 201386399.
[12]	Panera N, Crudele A, Romito I, et al. Focal adhesion kinase: Insight into molecular roles and functions in hepatocellular carcinoma. Int J Mol Sci, 2017, 18(1): 99. DOI: 10.3390/ ijms18010099.
[13]	Gao X, Wei T, Liao B, et al. Physiological stretch induced proliferation of human urothelial cells via integrin α6-FAK signaling pathway.Neurourol Urodyn, 2018, 37(7): 2114-2120. DOI: 10.1002/nau.23572.
[14]	Tomakidi P, Schulz S, Proksch S, et al. Focal adhesion kinase (FAK) perspectives in mechanobiology: implications for cell behaviour. Cell Tissue Res, 2014, 357(3): 515-526. DOI: 10.1007/s00441-014-1945-2.
[15]	Hu YL, Lu S, Szeto KW, et al. FAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells. Sci Rep, 2014, 4: 6024. DOI: 10.1038/srep06024.
[16]	Chang SJ, Chen YC, Yang CH, et al. Revealing the three dimensional architecture of focal adhesion components to explain Ca2+-mediated turnover of focal adhesions. Biochim Biophys Acta Gen Subj, 2017, 1861(3): 624-635. DOI: 10.1016/ j.bbagen.2017.01.002.
[17]	Yao L, Li K, Peng W, et al. An aberrant spliced transcript of focal adhesion kinase is exclusively expressed in human breast cancer. J Transl Med, 2014, 12: 136. DOI: 10.1186/1479-5876- 12-136.
[18]	Zhao XK, Yu L, Cheng ML, et al. Focal adhesion kinase regulates hepatic stellate cell activation and liver fibrosis. Sci Rep, 2017, 7(1): 4032. DOI: 10.1038/s41598-017-04317-0.
[19]	Park GB, Kim D. Cigarette smoke-induced EGFR activation promotes epithelial mesenchymal migration of human retinal pigment epithelial cells through regulation of the FAK-mediated Syk/Src pathway. Mol Med Rep, 2018, 17(3): 3563-3574. DOI: 10.3892/mmr.2017.8355.
[20]	Kokkinos MI, Brown HJ, de Iongh RU. Focal adhesion kinase (FAK) expression and activation during lens development. Mol Vis, 2007, 13(43-46): 418-430.
[21]	Zhu HY, Riau AK, Beuerman RW. Epithelial microfilament regulators show regional distribution in mouse conjunctiva. Mol Vis, 2010, 16(237-238): 2215-2224.
[22]	Pan Q, Qiu WY, Huo YN, et al. Low levels of hydrogen peroxide stimulate corneal epithelial cell adhesion, migration, and wound healing. Invest Ophthalmol Vis Sci, 2011, 52(3): 1723-1734. DOI: 10.1167/iovs.10-5866.
[23]	Yang YN, Wang F, Zhou W, et al. TNF-α stimulates MMP-2 and MMP-9 activities in human corneal epithelial cells via the activation of FAK/ERK signaling. Ophthalmic Res, 2012, 48(4): 165-170. DOI: 10.1159/000338819.
[24]	Gagen D, Filla MS, Clark R, et al. Activated αvβ3 integrin regulates αvβ5 integrin-mediated phagocytosis in trabecular meshwork cells. Invest Ophthalmol Vis Sci, 2013, 54(7): 5000- 5011. DOI: 10.1167/iovs.13-12084.
[25]	Yang X, Liu B, Bai Y, et al. Elevated pressure downregulates ZO-1 expression and disrupts cytoskeleton and focal adhesion in human trabecular meshwork cells. Mol Vis, 2011, 17(320-321): 2978-2985.
[26]	Liu B, Kilpatrick JI, Lukasz B, et al. Increased substrate stiffness elicits a myofibroblastic phenotype in human lamina cribrosa cells. Invest Ophthalmol Vis Sci, 2018, 59(2): 803-814. DOI: 10.1167/iovs.17-22400.
[27]	Hayes JM, Hartsock A, Clark BS, et al. Integrin α5/fibronectin1 and focal adhesion kinase are required for lens fiber morphogenesis in zebrafish. Mol Biol Cell, 2012, 23(24): 4725- 4738. DOI: 10.1091/mbc.E12-09-0672.
[28]	Wederell ED, de Iongh RU. Extracellular matrix and integrin signaling in lens development and cataract. Semin Cell Dev Biol, 2006, 17(6): 759-776. DOI: 10.1016/j.semcdb.2006.10.006.
[29]	Qin Y, Zhu Y, Luo F, et al. Killing two birds with one stone: dual blockade of integrin and FGF signaling through targeting syndecan-4 in postoperative capsular opacification. Cell Death Dis, 2017, 8(7): e2920. DOI: 10.1038/cddis.2017.315.
[30]	Aguilar-Solis ED, Lee-Rivera I, álvarez-Arce A, et al. FAK phosphorylation plays a central role in thrombin-induced RPE cell migration. Cell Signal, 2017, 36: 56-66. DOI: 10.1016/ j.cellsig.2017.04.016.
[31]	Chen XL, Nam JO, Jean C, et al. VEGF-induced vascular permeability is mediated by FAK. Dev Cell, 2012, 22(1): 146- 157. DOI: 10.1016/j.devcel.2011.11.002.
[32]	Toutounchian JJ, Pagadala J, Miller DD, et al. Novel small molecule JP-153 targets the Src-FAK-Paxillin signaling complex to inhibit VEGF-induced retinal angiogenesis. Mol Pharmacol, 2017, 91(1): 1-13. DOI: 10.1124/mol.116.105031.