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Efficacy of an Autologous Neurosensory Retinal Transplant for Recurrent Macular Hole Retinal Detachment in Highly Myopic Eyes |
Yanzi Li, Changzhong Xu, Yong Liu, Xueqin Kang, Jianhua Wu |
Aier Eye Hospital of Wuhan University, Wuhan 430063, China |
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Abstract Objective: To study the clinical effect of autologous neurosensory retinal transplants in the treatment of recurrent macular hole retinal detachment (MHRD) in highly myopic eyes. Methods: This was a prospective clinical study. An open qualitative response one-way sequential test method was used. Seven patients (7 eyes) with recurrent macular hole retinal detachment in highly myopic eyes were admitted to Aier Eye Hospital of Wuhan University, and underwent autologous neurosensory retinal transplantation combined with silicone oil tamponade. The follow-up period was at least 3 months after silicone oil removal. The main outcomes included retinal anatomical reattachment rate, best corrected visual acuity (BCVA) and postoperative complications. A sequential test diagram was plotted based on the test results. The pre-BCVA and post-BCVA were compared using a paired t-test. Results: Anatomical reattachment succeeded in 6 cases and failed in 1 case. The test line for the 7th case reached the upper boundary U. The retinal anatomical reattachment rate was 86%. At the last follow-up, the mean BCVA (1.35±0.34) logMAR was significantly improved over the pre-BCVA (2.06±0.33) logMAR (t=5.977, P=0.001). There were no serious complications such as vitreous hemorrhage, endophthalmitis, proliferation or the hole reopening at the retinal resection site. Two patients experienced transient intraocular hypertension, and intraocular pressure returned to normal within one week after antihypertensive drug treatment. Conclusions: Autologous neurosensory retinal transplants can treat recurrent MHRD effectively in highly myopic eyes and can significantly improve BCVA.
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Received: 28 December 2019
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Fund: Medical Research Fund of Wuhan Municipal Health Commission (WX18B09) |
Corresponding Authors:
Jianhua Wu, Aier Eye Hospital of Wuhan University, Wuhan 430063, China (Email: wjheye@163.com)
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[1] |
Mitry D, Zambarakji H. Recent trends in the management of maculopathy secondary to pathological myopia. Graefes Arch Clin Exp Ophthalmol, 2012, 250(1): 3-13. DOI: 10.1007/ s00417-011-1889-0.
|
[2] |
Ripandelli G, Rossi T, Scarinci F, et al. Macular vitreoretinal interface abnormalities in highly myopic eyes with posterior staphyloma: 5-year follow-up. Retina, 2012, 32(8): 1531-1538. DOI: 10.1097/IAE.0b013e318255062c.
|
[3] |
Gonvers M, Machemer R. A new approach to treating retinal detachment with macular hole. Am J Ophthalmol, 1982, 94(4): 468-472. DOI: 10.1016/0002-9394(82)90240-9.
|
[4] |
徐昶中, 吴建华, 何俊文, 等.单层内界膜翻转治疗高度近视眼黄斑裂孔视网膜脱离的临床观察. 中华眼科杂志, 2017, 53(5): 338-343. DOI: 10.3760/cma.j.issn.0412-4081.2017. 05.005.
|
[5] |
Sasaki H, Shiono A, Kogo J, et al. Inverted internal limiting membrane flap technique as a useful procedure for macular hole-associated retinal detachment in highly myopic eyes. Eye (Lond), 2017, 31(4): 545-550. DOI: 10.1038/eye.2016.263.
|
[6] |
Baba R, Wakabayashi Y, Umazume K, et al. Efficacy of the inverted internal limiting membrane flap technique with vitrectomy for retinal detachment associated with myopic macular holes. Retina, 2017, 37(3): 466-471. DOI: 10.1097/ IAE.0000000000001211.
|
[7] |
Park JH, Lee SM, Park SW, et al. Comparative analysis of large macular hole surgeries using an internal limiting membrane: Insertion technique versus inverted flap technique.Br J Ophthalmol, 2019, 2: 103. DOI: 10.1136/ bjophthalmol-2017-311770.
|
[8] |
Chen SN, Yang CM.Inverted internal limiting membrane insertion for macular hole-associated retinal detachment in high myopia. Am J Ophthalmol, 2016, 162: 99-106. DOI: 10.1016/ j.ajo.2015.11.013.
|
[9] |
Grewal DS, Mahmoud TH. Autologous neurosensory retinal free flap for closure of refractory myopic macular holes. JAMA ophthalmol, 2016, 134(2): 229-230. DOI: 10.1001/ jamaophthalmol.2015.5237.
|
[10] |
Ortisi E, Avitabile T, Bonfiglio V. Surgical management of retinal detachment because of macular hole in highly myopic eyes. Retina, 2012, 32(9): 1704-1718. DOI: 10.1097/ IAE.0b013e31826b671c.
|
[11] |
Wei Y, Wang N, Zu Z, et al. Efficacy of vitrectomy with triamcinolone assistance versus internal limiting membrane peeling for highly myopic macular hole retinal detachment. Retina, 2013, 33(6): 1151-1157. DOI: 10.1097/ IAE.0b013e31827b6422.
|
[12] |
Kang SW, Ahn K, Ham DI. Types of macular hole closure andtheir clinical implications.Br J Ophthalmol, 2003, 87(8): 1015- 1019. DOI: 10.1136/bjo.87.8.1015.
|
[13] |
Benhamou N, Massin P, Haouchine B, et al. Macular retinoschisis in highly myopic eyes. Am J Ophthalmol, 2002, 133(6): 794-800. DOI: 10.1016/s0002-9394(02)01394-6.
|
[14] |
Gandorfer A, Scheler R, Haritoglou C, et al. Pathology of the macular hole rim in flat-mounted internal limiting membrane specimens. Retina, 2009, 29(8): 1097-1105. DOI: 10.1097/ IAE.0b013e3181aa8fb1.
|
[15] |
Oie Y, Emi K, Takaoka G, et al. Effect of indocyanine green staining in peeling of internal limiting membrane for retinal detachment resulting from macular hole in myopic eyes. Ophthalmology, 2007, 114(2): 303-306. DOI: 10.1016/ j.ophtha.2006.07.052.
|
[16] |
Wolfensberger TJ, Gonvers M. Long-term follow-up of retinal detachment due to macular hole in myopic eyes treated by temporary silicone oil tamponade and laser photocoagulation. Ophthalmology, 1999, 106(9): 1786-1791. DOI: 10.1016/s0161- 6420(99)90344-5.
|
[17] |
Wolfensberger TJ, Gonvers M, Bovey E. Very long-term follow-up of retinal detachment due to macular hole treated with vitrectomy and air injection. Retina, 2001, 21(6): 678-681. DOI: 10.1097/00006982-200112000-00024.
|
[18] |
Lam RF, Lai WW, Cheung BT, et al. Pars plana vitrectomy and perfluoropropane (C3F8) tamponade for retinal detachment due to myopic macular hole: a prognostic factor analysis. Am J Ophthalmol, 2006, 142(6): 938-944. DOI: 10.1016/ j.ajo.2006.07.056.
|
[19] |
Gao X, Guo J, Meng X, et al. A meta-analysis of vitrectomy with or without internal limiting membrane peeling for macular hole retinal detachment in the highly myopic eyes. BMC Ophthalmol, 2016, 16: 87. DOI: 10.1186/s12886-016-0266-5.
|
[20] |
Takahashi H, Inoue M, Koto T, et al. Inverted internal limiting membrane flap technique for treatment of macular hole retinal detachment in highly myopic eyes. Retina, 2017, 0: 1-10. DOI: 10.1097/IAE.0000000000001898.
|
[21] |
Ikuno Y, Sayanagi K, Oshima T, et al. Optical coherence tomographic findings of macular holes and retinal detachment after vitrectomy in highly myopic eyes. Am J Ophthalmol, 2003, 136(3): 477-481. DOI: 10.1016/s0002-9394(03)00269-1.
|
[22] |
Grewal DS, Charles S, Parolini B, et al. Autologous Retinal Transplant for Refractory Macular Holes: Multicenter International Collaborative Study Group. Ophthalmology, 2019, 126(10): 1399-1408. DOI: 10.1016/j.ophtha.2019.01.027.
|
[23] |
Ding C, Li S, Zeng J. Autologous Neurosensory Retinal Transplantation for Unclosed and Large Macular Holes. Ophthalmic Res, 2019, 61(2): 88-93. DOI: 10.1159/000487952.
|
[24] |
Chen SN, Yang CM. Perfluorocarbon Liquid-Assisted Neurosensory Retinal Free Flap for Complicated Macular Hole Coexisting with Retinal Detachment. Ophthalmologica, 2019, 242(4): 222-233. DOI: 10.1159/000502443.
|
[25] |
Wu AL, Chuang LH, Wang NK, et al. Refractory macular hole repaired by autologous retinal graft and blood clot. BMC Ophthalmol, 2018, 18(1): 213. DOI: 10.1186/s12886-018-0898-8.
|
[26] |
Liu PK, Chang YC, Wu WC. Management of refractory macular hole with blood and gas-assisted autologous neurosensory retinal free flap transplantation: a case report. BMC Ophthalmol, 2018, 18(1): 230. DOI: 10.1186/s12886-018-0909-9.
|
[27] |
Glatt H, Machemer R. Experimental subretinal hemorrhage in rabbits. Am J Ophthalmol, 1982, 94(6): 762-773. DOI: 10.1016/ 0002-9394(82)90301-4.
|
[28] |
Thomas AS, Mahmoud TH. Subretinal transplantation of an autologous retinal free flap for chronic retinal detachment with proliferative vitreoretinopathy with and without macular hole. Retina, 2018, 38: 121-124. DOI: 10.1097/IAE. 0000000000002026.
|
[29] |
Parolini B, Grewal DS, Pinackatt SJ, et al. Combined autologous transplantation of neurosensory retina, retinal pigment epithelium, and choroid free grafts. Retina, 2018, 38(Suppl 1): 12-22. DOI: 10.1097/IAE.0000000000001914.
|
[30] |
Hayashi H. Foveal microstructure in macular holes surgically closed by inverted internal limiting membrane flap technique. Retina, 2014, (34): 2444-2450. DOI: 10.1097/IAE. 0000000000000252.
|
[1] |
Chinese Optometric Association, Chinese Ophthalmological Society; Ophthalmology and Optometry Committee, Ophthalmologists Association, Chinese Doctor Association; et al. Expert Consensus on Prevention and Control of High Myopia (2023)[J]. Chinese Journal of Optometry Ophthalmology and Visual science, 2023, 25(6): 401-407. |
|
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