盐酸环喷托酯、复方托吡卡胺与阿托品对儿童睫状肌麻痹效果的比较

doi:10.3760/cma.j.cn115909-20200512-00205

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Abstract Objective: To investigate and compare the cycloplegic effect of cyclopentolate, compound topicamide and atropine in children with different ages, refractive status and accommodative esotropia. Methods: This prospective clinical study had been conducted at Renmin Hospital of Wuhan University between September 2018 and September 2019 in 283 children (566 eyes) of 3-12 years old with refractive error. All the children were given 1% atropine to obtain the refractive diopter, and they were randomly divided into group A and group B. The two group are divided into 3-<6 years old group and 6-<12 years old group according to age. The 3-<6 years old group and the 6-<12 years old group are divided into three subgroups: The myopia group without esotropia, the hyperopia group without esotropia and the esotropia group. After 5 weeks, pupil size and light reflex back to normal. Group A received 1% cyclopentolate hydrochloride eye drops for computer optometry, and group B received 0.5% compound tropicamide eye drops for computer optometry. The Wilcoxon signed rank sum test was used to statistically analyze the difference of spherical equivalent of computer optometry before and after 1% atropine, and the difference of computer optometry after different cycloplegia. Results: The SE after 1% atropine was greater than before 1% atropine, the difference of SE was 1.75(1.00-2.75)D, and the difference was statistically significant (Z=-20.62, P<0.001). The difference was more obvious children with aged 3 to 6, children with hyperopia and children with esotropia (P<0.001). In group A, the SE after using 1% atropine was greater than that after using 1% cyclopentolate, and the difference of SE was 0.25(0.13-0.50)D (Z=-11.49, P<0.001). The difference of SE in 3-<6 years old group after using 1% atropine and 1% cyclopentolate in the myopia group without esotropia, hyperopia group without esotropia and esotropia group were 0.25(0.25-0.25)D, 0.38(0.25-0.50)D, 0.50(0.38-0.75)D (Z=-3.34, -7.36, -4.95, all P<0.001). The difference of SE of that 3 subgroups in the 6-<12 years group were 0(0-0.12)D, 0.25(0.12-0.25)D, 0.44(0.28-0.69)D (Z=-0.83, P=0.405; Z=-5.30, P<0.001; Z=-3.53, P<0.001). In group B, the SE after using 1% atropine was greater than that after using 0.5% compound tropicamide, and the difference of SE was 0.25(0.13-0.50)D (Z=-15.46, P<0.001). The difference of SE in 3-<6 years old group after using 1% atropine and 0.5% compound tropicamide in the myopia group without esotropia, hyperopia group without esotropia and esotropia group were 0.25(0.19- 0.25)D, 0.38(0.25-0.75)D, 0.69(0.30-1.03)D (Z=-3.15, P=0.002; Z=-9.89, P<0.001; Z=-4.79, P<0.001). The difference of SE of that 3 subgroups in the 6-<12 years group were 0(0-0.12)D, 0.32(0.13-0.38)D, 0.50(0.41-0.50)D (Z=-1.37, P=0.171; Z=-7.15, P<0.001; Z=-4.37, P<0.001). Conclusions: The spherical equivalent of mydriasis refraction with 1% cyclopentolate eye drops or 0.5% compound tropicamide eye drops is similar to that with 1% atropine in myopic children aged 6 to 12 years without esotropia, and it is different from that with 1% atropine in 3-<6 years old children and children with hyperopia and esotropia at 6-<12 years old.

Key words： cyclopentolate compound topicamide atropine cycloplegia

Received: 12 May 2020

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Fund: Hubei Provincial Central Guided Local Science and Technology Development (2019ZYYD058)

Corresponding Authors: Lianhong Zhou, Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan 430060, China (Email: zlh681102@aliyun.com)

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https://www.cjoovs.com/EN/10.3760/cma.j.cn115909-20200512-00205 OR https://www.cjoovs.com/EN/Y2020/V22/I12/889

[1]	Stolzar IH. A new group of cycloplegic drugs. Am J Ophthalmol, 1953, 36(1): 110-112. DOI: 10.1016/0002-9394(53)91517-7.
[2]	Negrel AD, Maul E, Pokharel GP, et al. Refractive error study in children: Sampling and measurement methods for a multicountry survey. Am J Ophthalmol, 2000, 129(4): 421-426. DOI: 10.1016/s0002-9394(99)00455-9.
[3]	Hiatt R L, Jerkins G. Comparison of atropine and tropicamide in esotropia. Ann Ophthalmol, 1983, 15(4): 341-343.
[4]	Bujara K, Schulz E, Haase W. Retinoscopy under cycloplegic and non-cycloplegic conditions in children comparison of measurements of three examiners (author's transl). Albrecht Von Graefes Arch Klin Exp Ophthalmol, 1981, 216(4): 339-343. DOI: 10.1007/BF00455041.
[5]	Wakayama A, Nishina S, Miki A, et al. Incidence of side effects of topical atropine sulfate and cyclopentolate hydrochloride for cycloplegia in Japanese children: A multicenter study. Jpn J Ophthalmol, 2018, 62(5): 531-536. DOI: 10.1007/s10384-018- 0612-7.
[6]	陈祖基. 眼科临床药理学. 2版. 北京: 化学工业出版社, 2011.
[7]	黄春联, 沈咲, 黄小明. 1%盐酸环喷托酯滴眼液滴眼后出现精神异常一例. 中华眼视光学与视觉科学杂志, 2019, 21(10): 794-795. DOI: 10.3760/cma.j.issn.1674-845X.2019.10.012.
[8]	Wright KW, Spiegel PH, Thompson LS. Handbook of pediatric strabismus and amblyopia. New York: Springer, 2006.
[9]	李军. 近视及屈光不正性弱视儿童调节功能的研究. 石家庄: 河北医科大学, 2008.
[10]	郭继援, 李仕明, 李翯, 等. 1%环戊通对近视儿童睫状肌麻痹效果的观察. 中华眼视光学与视觉科学杂志, 2015, 17(2): 96- 98. DOI: 10.3760/cma.j.issn.1674-845X.2015.02.008.
[11]	许江涛. 强效睫状肌麻痹剂环戊通能否替代阿托品.中华眼科杂志, 2012, 48(9): 772-775. DOI: 10.3760/cma.j.issn.0412- 4081.2012.09.003.
[12]	余琦, 邵寅. 盐酸环喷托酯滴眼液与阿托品眼膏在儿童验光中的比较. 中国斜视与小儿眼科杂志, 2014, 22(2): 25-27.
[13]	范恩越, 张艳丽, 穆珊珊. 快速散瞳验光在儿童屈光测量中的临床应用. 中国斜视与小儿眼科杂志, 2011, 19(4): 179-180, 167. DOI: 10.3969/j.issn.1005-328X.2011.04.012.

[1]	. [J]. Chinese Journal of Optometry Ophthalmology and Visual science, 2023, 25(8): 0-.