甲状腺相关眼病对角膜对称性及角膜屈光力的影响

doi:10.3760/cma.j.issn.1674-845X.2013.11.009

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Abstract

Objective To investigate the effect on cornea topographical characteristcs of thyroid-associated ophthalmology （TAO） disease. Methods In this prospective case control study， 46 eyes of 24 patients diagnosed with the inactive TAO were recruited as study group， 30（30 eyes） age and sex matched healthy volunteers were as control group. TAO was diagnosed based on the basis of criteria of Eruopean Group Grave′s Orbitopathy and the activity was decided by the Clinical Activity Score （CAS）. Cornea topographical characteristics of each group was obtained by using Pentacam system via one experienced doctor， including the index surface virance （ISV）， index of vertical asymmetry （IVA）， index of highest asymmetry （IHA）， index of highest decentration （IHD） and minimal sagittal curvature （Rim）， central cornea thickness （CCT）， refractive power and astigmatism of front and back cornea. Data were analyzed using independent to test and rank sum test. Results ISV in TAO was 21.00（10-71）， higher than control group [14.0（10-34）] （Z=1.31， P＜0.01）； IVA was 0.180（0.07-0.70）， higher than control group [0.100（0.50-0.37）]（Z=1.08， P＜0.01）； IHA was 5.950（0.0-28.7）， higher than control group [1.65（0.2-13.9）]（Z=84.34， P＜0.01）； IHD was 0.020±0.015， higher than control group （0.010±0.004）（t=5.67， P＜0.01）； Rim was 7.43±0.30 mm， lower than control group （7.62±0.26 mm）（t=-2.505， P＜0.01）； CCT was 523.74±26.00 μm， lower than control group （546.25±28.84 μm）（t=3.230， P＜0.01）； K1 of front cornea was 43.58±1.18 D， higher than control group （42.86±1.43 D），（t=2.123， P＜0.05）； K1 of back cornea was -6.20 D（-7.2--5.7 D）， higher than control group [-6.10 D（-6.6--5.7 D）]（Z=101.4， P＜0.01）. There was no siginificant difference in K2， astigmatism between study and control group. Conclusion The TAO may lead to the decrease of cornea symmetry and have an effect on refractive power of cornea.

Key words： Graves ophthalmopathy Cornea topograph Cornea refractive power Pentacam

Received: 24 August 2013

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	Articles by authors
	HE Xiang-jun
	HONG Ming-sheng
	YU Xin-jie
	CHEN Jie-ling
	ZHANG Li-na
	SHENG Wen
	MAO Jian-bo
	CHEN Feng
	SHEN Li-jun

Cite this article:

HE Xiang-jun,HONG Ming-sheng,YU Xin-jie等. A clinical research of the cornea symmetry and refractive power of thyroid-associated ophthalmology disease[J]. Chinese Journal of Optometry Ophthalmology and Visual Science, 2013, 15(11): 675-679.

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https://www.cjoovs.com/EN/10.3760/cma.j.issn.1674-845X.2013.11.009 OR https://www.cjoovs.com/EN/Y2013/V15/I11/675

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