儿童青少年近视患者屈光度与黄斑血流的相关性

doi:10.3760/cma.j.cn115909-20201105-00428

Abstract
Figure/Table
References (23)
Related Citation (15)

Download: PDF (2568 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS) Supporting Info

Guide

Abstract Objective: To investigate the relationship between amount of myopia and blood flow density and foveal avascular zone (FAZ) in the macular area in myopic children and adolescents. Methods: This was a case series study. The clinical data of 50 cases and 100 eyes of children and adolescents who were tested for myopia in the optometry clinic of Ningde City Hospital Affiliated to Ningde Normal University from July 2019 to January 2020 were collected for analysis. All subjects were examined for height, uncorrected visual acuity, refractive error, and corrected visual acuity. The eye axial length and OCTA in the macular area were also tested. Patients were divided into two groups according to the size of the equivalent spherical refractive error (SE): A low myopia-to-emmetropia group (-3.0 D<SE<+0.5 D) with 66 eyes and a moderate-to-high myopia group (SE≤-3.0 D) with 34 eyes. The differences in blood flow vascular density (VD), perfusion density (PD) and FAZ between the two groups were observed, as well as their correlations with the child's height and eye axial length. Analysis of variance, rank and inspection, and Pearson correlation analysis were used to test results for the macular blood flow, eye axial length and the child's height. Results: There was no statistically significant difference between the two groups in the vascular density of a 1 mm diameter area (VD1), the perfusion density of a 1 mm diameter area (PD1) and the perfusion density of a 6 mm diameter area (PD4) centered at the macular shallow layer. VD4 and FAZ were significantly different (t=3.870, P=0.031; t=6.237, P=0.014), FAZ was negatively correlated with eye axial length and age (r=-0.333, P=0.001; r=-0.289, P=0.042). Conclusions: The VD4 and FAZ of children and adolescents with low myopia are both larger than those with moderate-to-high myopia, and FAZ is negatively correlated with eye axial length and age, but the causal relationship needs further study.

Key words： myopia macular blood flow density optical coherence tomography angiography axis oculi foveal avascular zone children and adolescents

Received: 05 November 2020

PACS:

Fund:

Corresponding Authors: Xiaohan Zhang, Department of Ophthalmology, Ningde City Hospital Affiliated to Ningde Normal University, 352100, China (Email: 394483796@qq.com)

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

https://www.cjoovs.com/EN/10.3760/cma.j.cn115909-20201105-00428 OR https://www.cjoovs.com/EN/Y2021/V23/I4/272

[1]	Smith MJ ,Walline JJ. Controlling myopia progression in children and adolescents. Adolesc Health Med Ther, 2015, 6: 133-140. DOI: 10.2147/AHMT.S55834.
[2]	Morgan IG, Ohno-Mtsui K, Saw SM. Myopia.Lancet(London, England), 2012, 379(9827): 1739-1348. DOI: 10.1016/S0140- 6736(12)60272-4.
[3]	Fujiwara T, Imamura Y, Margolis R, et al. Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes. Am J Ophthalmol, 2009, 148(3): 445-450. DOI: 10.1016/j.ajo.2009.04.029.
[4]	Flores-Moreno I, Lugo F, Duker JS, et al. The relationship between axial length and choroidal thickness in eyes with high myopia. Am J Ophthalmol, 2013, 155(2): 314-319. DOI: 10.1016/j.ajo.2012.07.015.
[5]	Nishida Y, Fujiwara T, Imamura Y, et al. Choroidal thickness and visual acuity in highly myopic eyes. Retina, 2012, 32(7): 1229-1236. DOI: 10.1097/IAE.0b013e318242b990.
[6]	王颖, 于继, 李军, 等. 超声乳化与晶状体植入对高度近视并白内障患者中央角膜厚度及OCT的影响. 河北医学, 2018, 24(6): 931-935. DOI: 10.3969/j.issn.1006-6233.2018.06.013.
[7]	史兰琴, 宋虎平. 青少年近视眼黄斑参数与等效球镜、眼轴、性别及年龄的相关性分析. 中国中医眼科杂志, 2017, 27(3): 185-187. DOI: 10.13444/j.cnki.zgzyykzz.2017.03.012.
[8]	王丽霞, 王幼生, 王小川. 高度近视患者黄斑部视网膜厚度光学相干断层扫描分析. 临床医学工程, 2016, 23(3): 261-263. DOI: 10.3969/j.issn.1674-4659.2016.03.0261.
[9]	Chu Z, Lin J, Gao C, et al. Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography. J Biomed Opt, 2016, 21(6): 66008. DOI: 10.1117/1. JBO.21.6.066008.
[10]	赵琦, 杨文利, 魏文斌, 等. 基于光学微血流成像技术的相干光断层扫描血流成像对视网膜血流定量分析的可重复性评价. 眼科, 2018, 27: 107-110. DOI: 10.13281/j.cnki.issn.1004- 4469.2018.02.007.
[11]	肖风琪, 高健, 鲍伟利, 等. 运用光学相干断层扫描血管成像技术分析不同程度近视眼眼底微循环变化. 安徽医科大学学报, 2020, 55(10): 1592-1596. DOI: 10.19405/j.cnki.issn1000- 1492.2020.10.023.
[12]	谭亮章, 田芳, 张红. 基于OCTA的近视性屈光参差患者黄斑区血流密度及视网膜厚度分析. 眼科新进展, 2020, 40(3): 268-271. DOI: 10.13389/j.cnki.rao.2020.0063.
[13]	Lam JK, Chan TC, Ng AL, et al. Outcomes of cataract operations in extreme high axial myopia. Graefes Arch Clin Exp Ophthalmol, 2016, 254(9): 1811-1817. DOI: 10.1007/s00417-016-3414-y.
[14]	王伟伟, 王怀洲, 刘建荣, 等. 频域OCT测量高度近视黄斑区视网膜神经节细胞复合体厚度及视盘周围视网膜神经纤维层厚度. 中华眼视光学与视觉科学杂志, 2017, 19(12): 720- 726. DOI: 10.3760/cma.j.issn.1674-845X.2017.12.003.
[15]	楼方磊, 胡美君. 光学相干断层扫描在高度近视黄斑病变中的应用研究. 国际眼科杂志, 2018, 18(5): 937-940. DOI: 10.3980/j.issn.1672-5123.2018.5.43.
[16]	Shimada N, Ohno-Matsui K, Harino S, et al. Reduction of retinal blood flow in high myopia. Graefes Arch Clin Exp Ophthalmol, 2004, 242(4): 284-288. DOI: 10.1007/s00417-003-0836-0.
[17]	Yang Y, Wang J, Jiang H, et al. Retinal Microvasculature Alteration in High Myopia. Invest Ophthalmol Vis Sci, 2016, 57(14): 6020-6030. DOI: 10.1167/iovs.16-19542.
[18]	Sampson DM, Gong P, An D, et al. Axial length variation impacts on superficial retinal vessel density and foveal avascular zone area measurements using optical coherence tomography angiography. Invest Ophthalmol Vis Sci, 2017, 58(7): 3065- 3072. DOI: 10.1167/iovs.17-21551.
[19]	Al-Sheikh Mayss, Phasukkijwantana, Nopasak, et al. Quantitative OCT angiography of the retinal microvasculature and the choriocapillaris in myopic eyes. Invest Ophthalmol Vis Sci, 2017, 58(4): 2063-2069. DOI: 10.1167/iovs.16-21289.
[20]	Kim M, Kim SS, Kwon HJ, et al. Association between choroidal thickness and ocular perfusion pressure in young, healthy subjects: enhanced depth imaging optical coherence tomography study. Invest Ophthalmol Vis Sci, 2012, 53(12): 7710-7717. DOI: 10.1167/iovs.12-10464.
[21]	Wakabayashi T, Ikuno Y. Choroidal filling delay in choroidal neovascularisation due to pathological myopia. Br J Ophthalmol, 2010, 94(5): 611-615. DOI: 10.1136/bjo.2009.163535.
[22]	Shih YF, Fitzgerald ME, Norton TT, et al. Reduction in choroidal blood flow occurs in chicks wearing goggles that induce eye growth toward myopia. Curr Eye Res, 1993, 12(3): 219-227. DOI: 10.3109/02713689308999467.
[23]	胡瑶, 孙珂, 肖建强, 等. OCTA在儿童近视初步发展阶段的研究进展. 世界最新医学信息文摘, 2019, 19(86): 98-102. DOI: 10.19613/j.cnki.1671-3141.2019.86.043.

[1]	. [J]. Chinese Journal of Optometry Ophthalmology and Visual science, 2023, 25(8): 0-.