Objective: To observe the clinical treatment of Dihuangchufengyisuntang (self-made prescription)
combined with flumilone eye dropson improving the ocular surface state after pterygium surgery. Methods:
In this serial case study, select 60 patients who have made pterygium surgery, and randomly divided them
into treatment group 30 cases (38 eyes) and control group 28 cases (38 eyes). The treatment group was
treated with Dihuangchufengyisuntang combined with 0.1% flumilone eye drops, while the control group
was treated with 0.1% flumilone eye drops only, and the treatment lasted for 6 weeks. Corneal sodium
fluorescein staining (FL), SchirmerⅠ test (SⅠT) and break-up time (BUT) were performed at 2, 4 and 6
weeks of treatment, respectively. Eye pain, eye itching, eye discharge, lacrimation, dryeye, conjunctival
congestion, photophobia scores of Traditional Chinese Medicine treatment (TCM) clinical sympotoms
were determined according to Guidelines for Clinical Research of TCM New Drugs. All test indicators and
symptom scores were recorded. Data were analyzed by repetitive measurement deviation analysis, t text,
rank sum test and chi-square test. Results: After 2 weeks of treatment, there was statistically significant
difference in symptoms scores between the two groups (t=2.97, P=0.01). While there was no significant
difference in FL, SⅠT, BUT. At 4, 6 weeks of treatment, symptoms scores, FL, SⅠt, BUT were significantly
different between the two groups (after 4 weeks of treatment, t values are -4.03, -4.42, 5.10, 4.16; after 6
weeks of treatment, t values are -2.18, -2.02, 2.08, 2.31; P<0.05). Conclusion: Dihuangchufengyisuntang
combined with flumilone eye drops can obviously improve the ocular surface irritation symptoms after
pterygium operation, reduce corneal fluorescein sodium staining, prolong the tear film rupture time,
increase the tear secretion, and the clinical effect is significant and stable.
