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| Research Progress on the Safety of the Clinical Application of Orthokeratology |
| Wenchen Zhao, Xiangui He, Xun Xu |
| Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai 200040, China |
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Abstract At present, the effectiveness of orthokeratology lenses in controlling the progression of myopia has been preliminarily recognized, and it is one of the common clinical methods in the treatment of myopia. Orthokeratology is mainly used in children and adolescents, so there should be persistent concern about safety. This article reviews the information about orthokeratology's safety from related literature. Microbial keratitis is the most serious adverse reaction. Other common adverse reactions include corneal stromal infiltration, corneal epithelium damage, conjunctivitis, corneal pigment ring, in addition, changes in lacrimal film, endothelial cells, corneal thickness and corneal biomechanical properties may also bring potential safety concerns. There are few concordant conclusions on etiology, mechanism, incidence and long-term effects, which are needed to be confirmed by further studies. Currently, in view of the occurrence of myopia at a young age and the tendency of myopia to develop into high myopia, orthokeratology is an effective means of clinical myopia control, and has beneficial application values. But it is still important to pay attention to its application safety and evaluate its long-term effects.
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Received: 08 September 2020
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| Fund: Municipal Human Resources Development Program for Outstanding Young Talents in Medical
and Health Sciences in Shanghai (2017YQ019); National Key R&D Program of China(2019YFC0840607);
Discipline Leader Cultivation Program of Shanghai Three Year Action Plan on Strengthening Public Health System Construction (GWV-10.2-XD09) |
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Corresponding Authors:
Xiangui He, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai 200040, China (Email: xianhezi@163.com)
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