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| of Cytokines in the Contralateral Aqueous Humor after Phacoemulsifcation Combined with Intraocular Lens Implantation |
| Yu Gan1,Yingqi Li2,Yue Li3,Yuanling Xia2 |
| 1School of Clinical Medical, Guizhou Medical University, Guiyang 550004, China2Department of Ophthalmology, Affiliated Hospital of Guizhou Medical University, Guiyang 550004,China3Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital),Qingdao 266000, China |
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Abstract Objective: To investigate the effect of frst glance phacoemulsifcation combined with intraocular lens (IOL)implantation on the cytokines in the aqueous humor of the contralateral eye in patients with age-related cataract. Methods:This was a prospective cohort study. From January 2022 to March 2022, a total of 36 patients (72 eyes) undergoing bilateral cataract phacoemulsifcation combined with IOLimplantation in the Department of Ophthalmology, Affliated Hospital of Guizhou Medical University were selected in this study. The patients were divided into A(3-7 days) 12 cases (24 eyes), B (8-28 days) 12 cases (24 eyes) and C (>28 days) 12 cases (24 eyes) groups according to the interval between bilateral operations. The frst eye was marked as 1, and the second eye was marked as 2. Aqueous humor was collected at the beginning of binocular surgery, and the concentrations of interferon-γ (IFN-γ), interleukin 4 (IL-4), interleukin 10 (IL-10),and interleukin 17A (IL-17A) in the aqueous humor of both eyes were detected using electrochemilu-minescence detection technology. The alternations of aqueous humor cells and aqueous humor scintillation were observed at 1, 3 and 14 days after operation. Single factor analysis of variance was used to compare the concentration of cytokines in aqueous humor among multiple groups. Chi-square test was used for lens hardness comparison. Fisher exact test was used for aqueous scintillation comparison. And Kruskal Wallis H test was used for aqueous humor cell comparison. Results: The levels of IFN-γ, IL-4, IL-10, and IL-17Ain aqueous humor had no statistically signifcantdifferences between groups and within groups (all P>0.05). There was no signifcantdifference between 1 and 2 eyes at 1, 3 and 14 days after surgery for the comparison of aqueous humor cells and aqueous humor flicker (allP>0.05). Conclusions: After phacoemulsifcation combined with IOLimplantation in one eye of age-related cataract patients, there were no signifcant alternations in IFN-γ, IL-4, IL-10, and IL-17Ain the aqueous humor of the opposite eye.
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Received: 19 August 2022
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| Fund:Science and Technology Fund Project of Guizhou Provincial Health and Family Planning Commission (gzwjkj2017-1-043) |
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Corresponding Authors:
Yue Li, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao 266000, China (Email:349125841@qq.com); Yuanling Xia,Department of Ophthalmology, Affliated Hospital of Guizhou MedicalUniversity, Guiyang 550004, China (Email:2692594532@qq.com)
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. [J]. Chinese Journal of Optometry Ophthalmology and Visual science, 2023, 25(8): 0-. |
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