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| The Effect of Treatment on Macular Microvasculature in Children with AnisometropicAmblyopia |
| Min Tang, Liying Luo, Yang Fu |
| Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai 200080, China |
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Abstract Objective: To analyze the alternations of macular microcirculation in children with anisometropic amblyopia before and after treatment. Methods: This was a prospective study held from January 2019 to December 2020. Totally 42 children aged from 6 to 12 years old with anisometropic amblyopia were enrolled from the ophthalmology clinic of Shanghai General Hospital, and 27 children with non-amblyopia in the same age group were enrolled as a normal control group. Children with amblyopia received treatment and follow-up for at least 6 months. Optical coherence tomography angiography (OCTA) was used to analyze the macular vessel density of superficial capillary plexus (SCP) and deep capillary plexus (DCP), foveal avascular zone (FAZ), and macular thickness of both eyes before and after treatment. Data were corrected by eye axis length using Littman formula. Analysis of variance was used to compare the differences between amblyopic eyes, fellow eyes, and normal control group. And paired t-test was used to compare the differences before and after treatment for amblyopic eyes and fellow eyes. The alternations of visual acuity (LogMAR value) were analyzed in relation to the alternations of SCP, DCP, and FAZ. Results: At baseline, the vessel densities of whole image SCP, foveal SCP, whole image DCP and foveal DCP in amblyopic eyes were significantly smaller than those in fellow eyes and normal control group (all P<0.05), FAZ in amblyopic eyes were significantly greater than those in fellow eyes and the normal control group (F=53.57, P<0.001), while the differences between fellow eyes and the normal control group were not signifcant (P>0.05). After treatment, the vessel densities of whole image SCP and parafoveal SCP in amblyopic eyes were signifcantly higher than those at baseline (t=3.75, P=0.001; t=2.62, P=0.012), Whole image DCP in amblyopic eyes were significantly higher than those at baseline (t=2.63, P=0.012). But there was no significant difference between whole image SCP and whole image DCP in amblyopic eyes with fellow eyes and normal control group (P>0.05). FAZ in amblyopic eyes were signifcantly reduced from those at baseline (t=-2.33, P=0.025), but they were still significantly larger than those in fellow eyes and normal control group (F=32.38, P<0.001). Macular thickness did not show sighifcant difference between eyes irrespective treatment (P>0.05). After treatment, the best corrected visual acuity (LogMAR) of amblyopic eyes increased from 0.46±0.34 at baseline to 0.17±0.17 after treatment (t=4.91, P<0.001). There was no signifcant correlation between the alternations of visual acuity in amblyopic eyes with the alternations of whole image SCP, whole image DCP, and FAZ (all P>0.05). Conclusions: The vessel density of macular SCP and DCP in anisometropic amblyopia eyes are lower than those in normal eyes, while FAZ is greater. After amblyopia treatment, SCP, DCP and FAZ tend to approach to normal levels to a certain extent. There is no signifcant correlation between the alternations of visual acuity in amblyopic eyes with the alternations of SCP, DCP, and FAZ.
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Received: 17 November 2022
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Corresponding Authors:
Yang Fu, Email: fuyang_smile@126.com
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| [1] |
. [J]. Chinese Journal of Optometry Ophthalmology and Visual science, 2023, 25(8): 0-. |
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