|
|
|
| Application of Single-Cell RNASequencing in Diabetic Retinopathy |
| Dongling Niu1, Yanchun Zhang2, Hongli Liu1 |
| 1Clinical Laboratory Center, Xi'an People's Hospital, Xi'an Fourth Hospital, Affliated People's Hospital of Northwest University, Xi'an 710004, China2Shaanxi Eye Hospital, Xi'an People's Hospital, Xi'an Fourth Hospital, Affiliated People's Hospital of Northwest University, Xi'an Ocular Fundus Disease Research Institute, Xi'an 710004, China |
|
|
|
| Guide |
|
|
Abstract Diabetic retinopathy (DR) is the leading cause of blindness in the working population, and the pathogenesis is intricate and yet to be elucidated. Single-cell RNA-seq (scRNA-seq) provides a powerful tool to explore the pathogenesis of DR at single-cell resolution through in-depth analysis of cellular heterogeneity, functional changes and interactions. This article presents a review of the emerging scRNA-seq technology and its applications in DR, including studies of revealing the cell types and gene expression characteristics, deciphering the pathogenesis, and exploring new therapeutic targets and biomarkers of DR.
|
|
Received: 09 April 2023
|
|
|
| Fund:Shaanxi Provincial Key R&D Program (2021SF-162); Xi'an Science and Technology Plan Major Research Project[201805104YX12SF38(3)];Baikouin-Langmu Research Development Special Fund Project (BJ2020IIT001); Youth Program of Shaanxi Natural Science Basic Research Project (2023-JC-QN-0885);Alcon Project (75019437) |
|
Corresponding Authors:
Yanchun Zhang, Email: zhangyanchun1239@126.com
|
|
|
|
| [1] |
. [J]. Chinese Journal of Optometry Ophthalmology and Visual science, 2023, 25(8): 0-. |
|
|
|
|
